Hydrogels: A Promising Vehicle for the Topical Management of Atopic Dermatitis

Barbosa, Ana Isabel; Torres, Tiago; Lima, Sofia A. Costa

doi:10.1002/adtp.202100028

Cited by 18 publications

(16 citation statements)

References 84 publications

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“…Finally, the hydrogels must have good tissue adhesion to ensure stable residence on the skin and avoid the use of additional tape or gauze. Although some previous works have used hydrogels as AD skin dressings to deliver therapeutic factors 29 , 30 , these hydrogels often fail to meet the specific needs of AD management.…”

Section: Introductionmentioning

confidence: 99%

Hydrogel dressing integrating FAK inhibition and ROS scavenging for mechano-chemical treatment of atopic dermatitis

Jia

et al. 2023

Nat Commun

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Atopic dermatitis (AD) is a chronic skin disease caused by skin immune dyshomeostasis and accompanied by severe pruritus. Although oxidative stress and mechanical scratching can aggravate AD inflammation, treatment targeting scratching is often overlooked, and the efficiency of mechano-chemically synergistic therapy remains unclear. Here, we find that enhanced phosphorylation of focal adhesion kinase (FAK) is associated with scratch-exacerbated AD. We then develop a multifunctional hydrogel dressing that integrates oxidative stress modulation with FAK inhibition to synergistically treat AD. We show that the adhesive, self-healing and antimicrobial hydrogel is suitable for the unique scratching and bacterial environment of AD skin. We demonstrate that it can scavenge intracellular reactive oxygen species and reduce mechanically induced intercellular junction deficiency and inflammation. Furthermore, in mouse AD models with controlled scratching, we find that the hydrogel alleviates AD symptoms, rebuilds the skin barrier, and inhibits inflammation. These results suggest that the hydrogel integrating reactive oxygen species scavenging and FAK inhibition could serve as a promising skin dressing for synergistic AD treatment.

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Section: Introductionmentioning

confidence: 99%

Hydrogel dressing integrating FAK inhibition and ROS scavenging for mechano-chemical treatment of atopic dermatitis

Jia

et al. 2023

Nat Commun

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“…In particular, nanoparticles have gained attention owing to their site-specific delivery, skin permeability, and improved bioavailability. [58,59] We hypothesized that IAA-LDH could control the imbalance in immune responses in AD lesions by enhancing drug delivery through the skin. In our study, the in vitro release of IAA promoted the polarization of M0 macrophages to M2 macrophages.…”

Section: Discussionmentioning

confidence: 99%

Biofunctional Inorganic Layered Double Hydroxide Nanohybrid Enhances Immunotherapeutic Effect on Atopic Dermatitis Treatment

Byun,

Seo,

Lee

et al. 2023

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Atopic dermatitis (AD) is a widespread, recurrent, and chronic inflammatory skin condition that imposes a major burden on patients. Conventional treatments, such as corticosteroids, are associated with various side effects, underscoring the need for innovative therapeutic approaches. In this study, the possibility of using indole‐3‐acetic acid‐loaded layered double hydroxides (IAA‐LDHs) is evaluated as a novel treatment for AD. IAA is an auxin‐class plant hormone with antioxidant and anti‐inflammatory effects. Following the synthesis of IAA‐LDH nanohybrids, their ability to induce M2‐like macrophage polarization in macrophages obtained from mouse bone marrow is assessed. The antioxidant activity of IAA‐LDH is quantified by assessing the decrease in intracellular reactive oxygen species levels. The anti‐inflammatory and anti‐atopic characteristics of IAA‐LDH are evaluated in a mouse model of AD by examining the cutaneous tissues, immunological organs, and cells. The findings suggest that IAA‐LDH has great therapeutic potential as a candidate for AD treatment based on its in vitro and in vivo modulation of AD immunology, enhancement of macrophage polarization, and antioxidant activity. This inorganic drug delivery technology represents a promising new avenue for the development of safe and effective AD treatments.

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“…Aphanothece sacrum is a cyanobacterium from which sacran ( Figure 1 ) is extracted [ 33 , 82 ]. This polysaccharide has a high molecular weight (2.35 × 10 7 g/mol) and presents many carboxylic and sulfuric acid groups.…”

Section: Isolated Natural Compounds Included In Nanotechnology-based ...mentioning

confidence: 99%

Nanotechnology-Based Topical Delivery of Natural Products for the Management of Atopic Dermatitis

et al. 2023

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Atopic dermatitis (AD) is a chronic eczematous inflammatory disease that may arise from environmental, genetic, and immunological factors. Despite the efficacy of current treatment options such as corticosteroids, such approaches are mainly focused on symptom relief and may present certain undesirable side effects. In recent years, isolated natural compounds, oils, mixtures, and/or extracts have gained scientific attention because of their high efficiency and moderate to low toxicity. Despite their promising therapeutic effects, the applicability of such natural healthcare solutions is somewhat limited by their instability, poor solubility, and low bioavailability. Therefore, novel nanoformulation-based systems have been designed to overcome these limitations, thus enhancing the therapeutic potential, by promoting the capacity of these natural drugs to properly exert their action in AD-like skin lesions. To the best of our knowledge, this is the first literature review that has focused on summarizing recent nanoformulation-based solutions loaded with natural ingredients, specifically for the management of AD. We suggest that future studies should focus on robust clinical trials that may confirm the safety and effectiveness of such natural-based nanosystems, thus paving the way for more reliable AD treatments.

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Hydrogels: A Promising Vehicle for the Topical Management of Atopic Dermatitis

Cited by 18 publications

References 84 publications

Hydrogel dressing integrating FAK inhibition and ROS scavenging for mechano-chemical treatment of atopic dermatitis

Hydrogel dressing integrating FAK inhibition and ROS scavenging for mechano-chemical treatment of atopic dermatitis

Biofunctional Inorganic Layered Double Hydroxide Nanohybrid Enhances Immunotherapeutic Effect on Atopic Dermatitis Treatment

Nanotechnology-Based Topical Delivery of Natural Products for the Management of Atopic Dermatitis

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