Hydrogels and Their Applications in Targeted Drug Delivery

Narayanaswamy, Radhika; Torchilin, Vladimir P.

doi:10.1201/9780429295010-35

Cited by 16 publications

(15 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Carbohydrates are biocompatible, relatively inexpensive, structurally easy to functionalize, and overall green. There is an enormous amount of studies on gels for use as drug delivery systems and many of these examples use oligomers or polymers made from scaffolds of carbohydrates [ 133 , 134 ]. Many of these hydrogels are porous and can swell and shrink, which allows for them to be exemplary models for drug delivery applications.…”

Section: Applications Of Sugar-based Lmwgsmentioning

confidence: 99%

Recently Developed Carbohydrate Based Gelators and Their Applications

Morris

Bietsch

Bashaw

et al. 2021

Gels

View full text Add to dashboard Cite

Carbohydrate based low molecular weight gelators have been an intense subject of study over the past decade. The self-assembling systems built from natural products have high significance as biocompatible materials and renewable resources. The versatile structures available from naturally existing monosaccharides have enriched the molecular libraries that can be used for the construction of gelators. The bottom-up strategy in designing low molecular weight gelators (LMWGs) for a variety of applications has been adopted by many researchers. Rational design, along with some serendipitous discoveries, has resulted in multiple classes of molecular gelators. This review covers the literature from 2017–2020 on monosaccharide based gelators, including common hexoses, pentoses, along with some disaccharides and their derivatives. The structure-based design and structure to gelation property relationships are reviewed first, followed by stimuli-responsive gelators. The last section focuses on the applications of the sugar based gelators, including their utilization in environmental remediation, ion sensing, catalysis, drug delivery and 3D-printing. We will also review the available LMWGs and their structure correlations to the desired properties for different applications. This review aims at elucidating the design principles and structural features that are pertinent to various applications and hope to provide certain guidelines for researchers that are working at the interface of chemistry, biochemistry, and materials science.

show abstract

Section: Applications Of Sugar-based Lmwgsmentioning

confidence: 99%

Recently Developed Carbohydrate Based Gelators and Their Applications

Morris

Bietsch

Bashaw

et al. 2021

Gels

View full text Add to dashboard Cite

show abstract

“…To address this scenario, the storage and delivery of plasma-generated RONS in the form of hydrogels is currently under investigation. These biomaterials have been demonstrated to be suitable vehicles for controlled drug release, so this is being approached in CAP therapies by using injectable polymeric hydrogel solutions that are able to cross-link in vivo, opening the door to local and controlled delivery of RONS to the tumor site ( Figure 3 B) [ 108 , 109 , 110 , 111 ].…”

Section: Potential Application Of Cap In Osmentioning

confidence: 99%

Cold Atmospheric Plasma: A New Strategy Based Primarily on Oxidative Stress for Osteosarcoma Therapy

Mateu-Sanz

Tornín

Ginebra

et al. 2021

JCM

View full text Add to dashboard Cite

Osteosarcoma is the most common primary bone tumor, and its first line of treatment presents a high failure rate. The 5-year survival for children and teenagers with osteosarcoma is 70% (if diagnosed before it has metastasized) or 20% (if spread at the time of diagnosis), stressing the need for novel therapies. Recently, cold atmospheric plasmas (ionized gases consisting of UV–Vis radiation, electromagnetic fields and a great variety of reactive species) and plasma-treated liquids have been shown to have the potential to selectively eliminate cancer cells in different tumors through an oxidative stress-dependent mechanism. In this work, we review the current state of the art in cold plasma therapy for osteosarcoma. Specifically, we emphasize the mechanisms unveiled thus far regarding the action of plasmas on osteosarcoma. Finally, we review current and potential future approaches, emphasizing the most critical challenges for the development of osteosarcoma therapies based on this emerging technique.

show abstract

“…This was demonstrated when lipophilic non-hydroxylated coumarins were encapsulated in the core of β-cyclodextrin hydrogels for trypanocidal activity via mitochondrial membrane potential studies for Chagas disease caused by the protozoan parasite, Trypanosoma cruzi. Trypanocidal activity was increased by 10% with the Supramolecular hydrogels of β-cyclodextrin linked to calcium homopoly-Lguluronate as compared to the free corresponding amidocoumarins [17,18].…”

Section: Merits and Demerits Of Encapsulationmentioning

confidence: 99%

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques

Ngwuluka¹,

Abu-Thabit²,

Uwaezuoke³

et al. 2021

Nano- And Microencapsulation - Techniques and Applications

View full text Add to dashboard Cite

Encapsulation, specifically microencapsulation is an old technology with increasing applications in pharmaceutical, agrochemical, environmental, food, and cosmetic spaces. In the past two decades, the advancements in the field of nanotechnology opened the door for applying the encapsulation technology at the nanoscale level. Nanoencapsulation is highly utilized in designing effective drug delivery systems (DDSs) due to the fact that delivery of the encapsulated therapeutic/diagnostic agents to various sites in the human body depends on the size of the nanoparticles. Compared to microencapsulation, nanoencapsulation has superior performance which can improve bioavailability, increase drug solubility, delay or control drug release and enhance active/passive targeting of bioactive agents to the sites of action. Encapsulation, either micro- or nanoencapsulation is employed for the conventional pharmaceuticals, biopharmaceuticals, biologics, or bioactive drugs from natural sources as well as for diagnostics such as biomarkers. The outcome of any encapsulation process depends on the technique employed and the encapsulating material. This chapter discusses in details (1) various physical, mechanical, thermal, chemical, and physicochemical encapsulation techniques, (2) types and classifications of natural polymers (polysaccharides, proteins, and lipids) as safer, biocompatible and biodegradable encapsulating materials, and (3) the recent advances in using lipids for therapeutic and diagnostic applications. Polysaccharides and proteins are covered in the second part of this chapter.

show abstract

Hydrogels and Their Applications in Targeted Drug Delivery

Cited by 16 publications

References 1 publication

Recently Developed Carbohydrate Based Gelators and Their Applications

Recently Developed Carbohydrate Based Gelators and Their Applications

Cold Atmospheric Plasma: A New Strategy Based Primarily on Oxidative Stress for Osteosarcoma Therapy

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques

Contact Info

Product

Resources

About