Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

Ibrahim, Mohammed; Nair, Anroop B.; Al‐Dhubiab, Bandar E.; Shehata, Tamer M.

doi:10.5772/intechopen.68158

Cited by 16 publications

(15 citation statements)

References 113 publications

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“…A plastered patch comprising a paclitaxel-modified transfersomes hydrogel above the melanoma tumor provided extended retention capacity and significant suppression of tumor growth in combination with systemic chemotherapy using taxol [ 114 ]. Various studies have evaluated the role of hydrogels in promoting the dermal drug delivery via nanoparticulate carriers [ 115 ].…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management

et al. 2021

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The popularity of hydrogels as biomaterials lies in their tunable physical properties, ability to encapsulate small molecules and macromolecular drugs, water holding capacity, flexibility, and controllable degradability. Functionalization strategies to overcome the deficiencies of conventional hydrogels and expand the role of advanced hydrogels such as DNA hydrogels are extensively discussed in this review. Different types of cross-linking techniques, materials utilized, procedures, advantages, and disadvantages covering hydrogels are tabulated. The application of hydrogels, particularly in buccal, oral, vaginal, and transdermal drug delivery systems, are described. The review also focuses on composite hydrogels with enhanced properties that are being developed to meet the diverse demand of wound dressing materials. The unique advantages of hydrogel nanoparticles in targeted and intracellular delivery of various therapeutic agents are explained. Furthermore, different types of hydrogel-based materials utilized for tissue engineering applications and fabrication of contact lens are discussed. The article also provides an overview of selected examples of commercial products launched particularly in the area of oral and ocular drug delivery systems and wound dressing materials. Hydrogels can be prepared with a wide variety of properties, achieving biostable, bioresorbable, and biodegradable polymer matrices, whose mechanical properties and degree of swelling are tailored with a specific application. These unique features give them a promising future in the fields of drug delivery systems and applied biomedicine.

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Section: Drug Delivery Systemsmentioning

confidence: 99%

Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management

et al. 2021

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“…Transfersomes can efficiently penetrate through the pores having diameter of one‐fifth of their own diameter as per shown in Figure . [ 23,64–68 ] Ascenso et al. developed the transfersomes of tretinoin for the topical delivery.…”

Section: Vesicular Systemsmentioning

confidence: 99%

“…Transfersomes can efficiently penetrate through the pores having diameter of one-fifth of their own diameter as per shown in Figure 4. [23,[64][65][66][67][68] Ascenso et al developed the transfersomes of tretinoin for the topical delivery. Ex vivo permeation study showed that there was no detectable amount of drug in receptor compartment of Franz diffusion cell even after 24 h, suggesting the localized accumulation of tretinoin from the tranfersomes.…”

Section: Transfersomesmentioning

confidence: 99%

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Lipid Based Nanocarriers: Promising Drug Delivery System for Topical Application

Patel

Thakkar

2021

Euro J Lipid Sci & Tech

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Lipid based delivery system is gaining significant attention of researchers working on the development of novel formulations for improved therapeutic efficacy and safety of drugs. Topical drug delivery is needed in treatment of skin, eyes, rectum, vagina disorders and systemic disorders having skin manifestations. Lipid nanocarriers have widespread application in the topical drug delivery due to the biocompatible, biodegradable, nontoxic and nonirritating nature of the lipid. Microemulsion and nanoemulsion contain lipids in the nanosize range which can lead to penetration of drug to the deeper skin layers. Solid lipid nanoparticles and nanolipid carriers act by forming an occlusive layer on the skin leading to increased hydration and penetration of the drug. Vesicular carriers such as liposomes, niosomes, ultradeformable vesicles, cubosomes etc. are also reported to enhance the penetration of the entrapped drugs in deeper layers of skin. These carrier systems are mainly composed of lipids, surfactants, and co‐surfactants which are safe and quite acceptable by regulatory authorities. The present review article focuses on different types of lipid nanocarriers used in topical drug delivery, their advantages and limitations, mechanism of enhanced penetration, work reported in the related literature, characterization tests and their safety and toxicity concerns.

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“…In recent times, transdermal drug delivery systems have gained much attention owing to their high competence factors, such as more patient compliance, low frequency of dosing and avoiding many other problems usually related to the conventional oral dosage form [ 5 ]. Several dosage forms fall under the category of transdermal drug delivery systems, encompassing a variety of dosage forms such as gel, emulgel, nanoemulgel and patches [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Quality by Design for Development, Optimization and Characterization of Brucine Ethosomal Gel for Skin Cancer Delivery

et al. 2021

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Natural products have been extensively used for treating a wide variety of disorders. In recent times, Brucine (BRU) as one of the natural medications extracted from seeds of nux vomica, was investigated for its anticancer activity. As far as we know, this is the first study on BRU anticancer activity against skin cancer. Thus, the rational of this work was implemented to develop, optimize and characterize the anticancer activity of BRU loaded ethosomal gel. Basically, thin film hydration method was used to formulate BRU ethosomal preparations, by means of Central composite design (CCD), which were operated to construct (32) factorial design. Two independent variables were designated (phospholipid percentage and ethanol percentage) with three responses (vesicular size, encapsulation efficiency and flux). Based on the desirability function, one formula was selected and incorporated into HPMC gel base to develop BRU loaded ethosomal gel. The fabricated gel was assessed for all physical characterization. In-vitro release investigation, ex-vivo permeation and MTT calorimetric assay were performed. BRU loaded ethosomal gel exhibited acceptable values for the characterization parameters which stand proper for topical application. In-vitro release investigation was efficiently prolonged for 6 h. The flux from BRU loaded ethosome was enhanced screening optimum SSTF value. Finally, in-vitro cytotoxicity study proved that BRU loaded ethosomal gel significantly improved the anticancer activity of the drug against A375 human melanoma cell lines. Substantially, the investigation proposed a strong motivation for further study of the lately developed BRU loaded ethosomal gel as a prospective therapeutic strategy for melanoma treatment.

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Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

Cited by 16 publications

References 113 publications

Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management

Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management

Lipid Based Nanocarriers: Promising Drug Delivery System for Topical Application

Quality by Design for Development, Optimization and Characterization of Brucine Ethosomal Gel for Skin Cancer Delivery

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