Hydrogels as Controlled Drug Delivery System: A Brief Review of Properties Classification and Synthesis

Abstract

Hyrogels are cariers of novel drug delievry system and these polymeric network have ability to hold large amount of water but they do not dissolve in water .These polymeric network may be crosslinked either through chemical or physical crosslinking method. Without changing their three dimensional structure hydrogels undergo the swelling mechanism Hydrogels are used as drug delivery carriers because of their distinctive properties. They have three dimensional configurations and have water soluble cross linked network of polymers .Hydrogels have porous structure and by changing the cross linker concentration we can modify their affinity for water. Because of their unique properties these are used for various medical purposes like cellular immobilization , tissue engineering ,diagnostics and regenerative medicines.

Formulation and Evaluation of Fluconazole Niosomal Gel

“…Non-ionic surfactants play a crucial role in Niosomes formulation. These molecules, featuring a polar head and a non-polar tail, form bilayer structures with hydrophilic heads and hydrophobic tails [4] . The resulting vesicles fold inwards for thermal stability, and their lack of charge contributes to stability.…”

“…Examples of non-ionic surfactants include Spans and Tweens. Cholesterol Cholesterol plays a significant role in Niosome formulation, contributing to various properties of the formulation [4] . While not mandatory, it enhances stability when combined with surfactants with lower HLB values.…”

“…Charged molecules are included to prevent Niosome fusion and enhance stability. It's essential to maintain a concentration range of 2.5-5 mol% for effective results, as higher concentrations of charged molecules can inhibit Niosome production in formulations [4] .…”

“…Charge and zeta potential are determined using zetasizer. It is important to know the charge on the Niosomes as it is responsible for stability of the formulation [4,8]. The niosomal solution was diluted with distilled water and particle size, PDI, ad Zeta potential was analysed using Malvern zetasizer.…”