Hydrogels as local depots for on-demand therapeutic delivery: potential therapeutic approaches for tumor metastasis

Andrgie, Abegaz Tizazu; Tsai, Hsieh-Chih

doi:10.1039/d4ma00122b

Mater. Adv.

2024

DOI: 10.1039/d4ma00122b

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Hydrogels as local depots for on-demand therapeutic delivery: potential therapeutic approaches for tumor metastasis

Abegaz Tizazu Andrgie,

Hsieh-Chih Tsai

Abstract: Tumor metastasis, the spread of tumor cells from primary focus into surrounding tissues and then distant organs through vasculatures is the major cause of cancer mortality. Despite recent advances in...

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A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials

Choi,

Jeong

2024

Gels

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Hydrogels are known for their high water retention capacity and biocompatibility and have become essential materials in tissue engineering and drug delivery systems. This review explores recent advancements in hydrogel technology, focusing on innovative types such as self-healing, tough, smart, and hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited for applications in dynamic biomedical environments. Tough hydrogels are designed with enhanced mechanical properties, enabling their use in load-bearing applications such as cartilage regeneration. Smart hydrogels respond to external stimuli, including changes in pH, temperature, and electromagnetic fields, making them ideal for controlled drug release tailored to specific medical needs. Hybrid hydrogels, made from both natural and synthetic polymers, combine bioactivity and mechanical resilience, which is particularly valuable in engineering complex tissues. Despite these innovations, challenges such as optimizing biocompatibility, adjusting degradation rates, and scaling up production remain. This review provides an in-depth analysis of these emerging hydrogel technologies, highlighting their transformative potential in both tissue engineering and drug delivery while outlining future directions for their development in biomedical applications.

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A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials

Choi,

Jeong

2024

Gels

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show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Hydrogels as local depots for on-demand therapeutic delivery: potential therapeutic approaches for tumor metastasis

Abstract: Tumor metastasis, the spread of tumor cells from primary focus into surrounding tissues and then distant organs through vasculatures is the major cause of cancer mortality. Despite recent advances in...

Cited by 1 publication

References 153 publications

A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials

A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials

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