Hydrogels containing rutin intended for cutaneous administration: efficacy in wound healing in rats

Almeida, Juliana Sousa de; Benvegnú, Dalila Moter; Boufleur, Nardeli; Reckziegel, Patrícia; Barcelos, Raquel Cristine Silva; Coradini, Karine; Carvalho, Leandro Machado de; Bürger, Marilise Escobar; Beck, Ruy Carlos Ruver

doi:10.3109/03639045.2011.628676

Cited by 50 publications

(29 citation statements)

References 40 publications

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“…In previous studies rutin has shown wound healing activity in vitro [21] as well as in vivo [22]. Rutin has also shown antioxidant activity [23] as another approach for wound healing.…”

Section: Resultsmentioning

confidence: 99%

Determination of the Wound Healing Potentials of Medicinal Plants Historically Used in Ghana

Freiesleben

Soelberg

Nyberg

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The present study was carried out to investigate the wound healing potentials of 17 medicinal plants historically used in Ghana for wound healing. Warm and cold water extracts were prepared from the 17 dried plant species and tested in vitro in the scratch assay with NIH 3T3 fibroblasts from mice. The wound healing scratch assay was used to evaluate the effect of the plants on cell proliferation and/or migration in vitro, as a test for potential wound healing properties. After 21 hours of incubation increased proliferation and/or migration of fibroblasts in the scratch assay was obtained for 5 out of the 17 plant species. HPLC separation of the most active plant extract, which was a warm water extract of Philenoptera cyanescens, revealed the wound healing activity to be attributed to rutin and a triglycoside of quercetin. The present study suggests that Allophylus spicatus, Philenoptera cyanescens, Melanthera scandens, Ocimum gratissimum, and Jasminum dichotomum have wound healing activity in vitro.

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“…In previous studies rutin has shown wound healing activity in vitro [21] as well as in vivo [22]. Rutin has also shown antioxidant activity [23] as another approach for wound healing.…”

Section: Resultsmentioning

confidence: 99%

Determination of the Wound Healing Potentials of Medicinal Plants Historically Used in Ghana

Freiesleben

Soelberg

Nyberg

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…Considering the topical administration, this rheological behavior is interesting, since under medium to high shear stress values, the formulation flow resistance is lowered 33,34 , which can facilitate administration. Similar rheological behavior (non-Newtonian, Herschel-Bulkley model) was observed for gel-cream sunscreen formulations 15 and hydrogels containing rutin, when Carbopol Ultrez Õ 10 NF was used as gel-forming polymer 35 .…”

Section: Resultsmentioning

confidence: 51%

In vitro and in vivo evaluation of a desonide gel-cream photostabilized with benzophenone-3

Rosa

Santos²,

Lehmen³

et al. 2015

Drug Development and Industrial Pharmacy

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“…The absence of secondary products (amines) is demonstrated by the weak acid character of suspensions. Beside, these pH values are appropriate for products intended for cutaneous administration [12]. …”

Section: Resultsmentioning

confidence: 99%

Synthesis and preliminary in vivo evaluations of polyurethane microstructures for transdermal drug delivery

Borcan

Şoica

Ganta

et al. 2012

Chemistry Central Journal

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BackgroundPolymers have been considered as important materials in fabrication of microstructures for various medical purposes including drug delivery. This study evaluates polyurethane as material for hollow microstructures preparation.ResultsPolyurethane microstructures were obtained by interfacial polyaddition combined with spontaneous emulsification and present slightly acid pH values. Scanning electron microscopy revealed the existence of irregular shapes and agglomerated microstructures. The material is heat resistant up to 280°C. Good results were recorded on murine skin tests in case of polyurethane microstructures based on isophorone diisocyanate. Mesenchymal stem cells viability presents good results for the same sample after 48 hours based on the Alamar Blue test.ConclusionsThe research revealed the reduced noxiousness of this type of microstructures and consequently the possibility of their use for therapeutic purposes.

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Hydrogels containing rutin intended for cutaneous administration: efficacy in wound healing in rats

Abstract: This study shows for the first time the feasibility of using dermatological formulations containing rutin to improve skin wound healing.

Cited by 50 publications

References 40 publications

Determination of the Wound Healing Potentials of Medicinal Plants Historically Used in Ghana

Determination of the Wound Healing Potentials of Medicinal Plants Historically Used in Ghana

In vitro and in vivo evaluation of a desonide gel-cream photostabilized with benzophenone-3

Synthesis and preliminary in vivo evaluations of polyurethane microstructures for transdermal drug delivery

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