Hydrogels containing water soluble conjugates of silver(i) ions with amino acids, metabolites or natural products for non infectious contact lenses

Abstract

The poor handling and hygiene practices of contact lenses are the key reasons for the frequent contamination of them, which are responsible for developing ocular complications, such as microbial keratitis...

Silver(i) complexes bearing heterocyclic thioamide ligands with NH2 and CF3 substituents: effect of ligand group substitution on antibacterial and anticancer properties

“…[8][9][10][11][12][13][14][15] Moreover, antiseptic and antibacterial properties of Ag(I) compounds have been known since ancient times. [16][17][18][19] In general, the bioactivity potential of Ag(I) compounds is suggested to arise from their unique mechanisms of action. In particular, the mechanism of their antiproliferative activity differs from that of the DNA-targeting Pt-based drugs, as it is suggested to involve their interaction with the mito-chondrial membrane and inhibition of thioredoxin reductase, 20 leading to mitochondria initiated programmed cell death.…”

Tetracycline: structural characterization and antimicrobial properties of its water-soluble di-anionic bi-sodium salt

“…To determine whether the formulation falls into the category of bacteriostatic (MBC/MIC ≥ 4), where the organism is inhibited but not killed or bactericidal (MBC/MIC ≤ 2), where 99.9% of microorganisms are killed, the MBC/MIC ratios were calculated [22][23][24][25][26][27][28][29][30]39]. For TCNa, the MBC/MIC ratios are ≥ 4, indicating that it can be classified as bacteriostatic.…”

“…During our investigations into the design and creation of innovative formulations, aimed at overcoming bacterial resistance experienced by existing antibiotics [22][23][24][25][26][27][28][29][30], we have successfully synthesized and characterized a modified version of the commercially available drug tetracycline (TCH The in vitro toxicity of TCNa was estimated using normal human corneal epithelial cells (HCECs). Additionally, the Artemia salina model was employed to evaluate the in vivo toxicity of TCNa.…”

Supramolecular Hydrogels: Design Strategies and Contemporary Biomedical Applications

“…[3] However, these are mostly covalently bonded hydrogels. [224] These hydrogels contact lenses were previously limited by their oxygen permeability, which could lead to hypoxia-induced complications, [225] such as limbal redness neovascularization and corneal swelling, [226] which is now being addressed. In addition to high oxygen permeability, soft contact lenses are developed to be transparent, stable with good mechanical properties, comfortable, not irritate the eye and safe for daily use.…”

“…More recently there have been notable advancements using hydrogel‐based soft contact lenses for sustained drug release, [223] which are made via spin casting, lathe cutting or cast molding [3] . However, these are mostly covalently bonded hydrogels [224] . These hydrogels contact lenses were previously limited by their oxygen permeability, which could lead to hypoxia‐induced complications, [225] such as limbal redness neovascularization and corneal swelling, [226] which is now being addressed.…”