Hydrogels in drug delivery: Progress and challenges

Hoare, Todd; Kohane, Daniel S.

doi:10.1016/j.polymer.2008.01.027

Cited by 3,305 publications

(2,413 citation statements)

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“…Several authors have reported various protein and hydrophilic small molecule release from these nanoscaffolds, including BFGF, VEGF, and BDNF, 19,20 human antibodies, 21 where protein release depended primarily on the size of the protein and network density of nanofibers. Sustained release of smaller dyes molecules that contain sulfonic acid groups from (RADA) 4 nanoscaffolds have been reported; 22 however, few studies have reported the delivery of uncharged hydrophobic small molecules via this type of system.…”

Section: Introductionmentioning

confidence: 99%

“…Although the alanine side chains of (RADA) 4 are hydrophobic and thought to drive assembly through interpeptide hydrophobic interactions, direct encapsulation of hydrophobic molecules within the hydrophobic phase of the resulting β-sheet is hard. Several hydrophobic anticancer drugs (e.g., paclitaxel, 23 ellipticine, 24,25 curcumin, 26 etc.)…”

Section: Introductionmentioning

confidence: 99%

“…Several hydrophobic anticancer drugs (e.g., paclitaxel, 23 ellipticine, 24,25 curcumin, 26 etc.) have been attempted to be released by (RADA) 4 or other similar ioncomplementary self-assembling peptides (e.g., EAK16-IV, EAK16-II and EFK-II, 24,27−29 MAX8, 30,31 etc.). However, the usual result of these attempts is either an inhibited nanofiber formation (significant decrease in β-sheet content) 23 or an inability to form nanofiber networks at all: most result in a peptide-drug/microcrystal complex.…”

Section: Introductionmentioning

confidence: 99%

“…The pK a of the amine group in CS is ∼6.5; thus, the CS-based nanoparticles may dissociate at physiological condition (pH 7.4), a trait that may significantly limit their use in systemic applications. 36−38 However, this inherent property is suited for inclusion in a (RADA) 4 hydrogel, as this matrix can assemble in acidic environments (∼pH 4.0, 40 ), and formed nanofibers may stabilize the embedded nanoparticle structure allowing for a reduced rate of dissociation upon changing the environmental pH. Cyclodextrins (CDs) are a family of compounds composed of −(1, 4) linked glucopyranose subunits bound together to form a cyclic oligosaccharide.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, it has already been shown that the aqueous solubility of Dex (∼0.1 mg/mL) has been enhanced by the pharmaceutical industry for decades using cyclodextrins. 43 In this report, the release of Dex from (RADA) 4 based composite matrices was achieved using a CM-β-CD/Dex based nanoparticle that was mixed with self-assembling peptides to form a hybrid nanoscaffold. The influence of incorporating these nanoparticles on the matrix morphology was also evaluated.…”

Section: Introductionmentioning

confidence: 99%

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pH-Triggered Release of Hydrophobic Molecules from Self-Assembling Hybrid Nanoscaffolds

Lü

Unsworth

2016

Biomacromolecules

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Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses coordonnées. Si vous n'arrivez pas à les repérer, communiquez avec nous à PublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. Questions? Contact the NRC Publications Archive team atPublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. If you wish to email the authors directly, please see the first page of the publication for their contact information. NRC Publications Archive Archives des publications du CNRCThis publication could be one of several versions: author's original, accepted manuscript or the publisher's version. / La version de cette publication peut être l'une des suivantes : la version prépublication de l'auteur, la version acceptée du manuscrit ou la version de l'éditeur. For the publisher's version, please access the DOI link below./ Pour consulter la version de l'éditeur, utilisez le lien DOI ci-dessous.http://doi.org/10.1021/acs.biomac.6b00040Access and use of this website and the material on it are subject to the Terms and Conditions set forth at pH-triggered release of hydrophobic molecules from self-assembling hybrid nanoscaffolds Lu, Lei; Unsworth, Larry D.http://nparc.cisti-icist.nrc-cnrc.gc.ca/fra/droits L'accès à ce site Web et l'utilisation de son contenu sont assujettis aux conditions présentées dans le site LISEZ CES CONDITIONS ATTENTIVEMENT AVANT D'UTILISER CE SITE WEB. NRC Publications Record / Notice d'Archives des publications de CNRC:http://nparc.cisti-icist.nrc-cnrc.gc.ca/eng/view/object/?id=9e4287db-e138-42bd-a2f4-805f4418351b http://nparc.cisti-icist.nrc-cnrc.gc.ca/fra/voir/objet/?id=9e4287db-e138-42bd-a2f4-805f4418351b pH-Triggered Release of Hydrophobic Molecules from SelfAssembling Hybrid Nanoscaffolds Lei Lu †, ‡ and Larry D. Unsworth* , †, ‡ † Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 2V4, Canada ‡ National Institute for Nanotechnology, National Research Council (Canada), Edmonton, Alberta T6G 2M9, Canada * S Supporting Information ABSTRACT: Self-assembling peptide based hydrogels have a wide range of applications in the field of tissue repair and tissue regeneration. Because of its physicochemical properties, (RADA) 4 has been studied as a potential platform for 3D cell culture, drug delivery, and tissue engineering. Despite some small molecule and protein release studies with this system, there is a lack of work investigating the controlled release of hydrophobic compounds (i.e., anti-inflammatory, anticancer, antibacterial drugs, etc.) that are important for many clinical therapies. Attempts to incorporate hydrophobic compounds into self-assembling matrices usually inhibited nanofiber formation, rather resulting in a peptide−drug complex or microcrystal formation. Herein, a selfassembling chitosan/carboxymethyl-β-cyclodextrin nanoparticle system was used to load dexamethasone, which formed within a self-assembling (RADA...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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pH-Triggered Release of Hydrophobic Molecules from Self-Assembling Hybrid Nanoscaffolds

Lü

Unsworth

2016

Biomacromolecules

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Hydrogels

Ray

2022

Kirk-Othmer Encyclopedia of Chemical Technology

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Hydrogels are prepared by physical or chemical cross‐linking of water‐soluble polymers. Natural, semisynthetic, and synthetic polymers may be cross‐linked physically or by a cross‐linker to produce the network structure of a hydrogel. Because of cross‐linking these polymers are not soluble in water. However, hydrogels can absorb huge amount of water, resulting in significant swelling of their three‐dimensional network structure. The swelling of a responsive and smart hydrogel strongly depends on external stimuli such as pH, temperature, salt concentration, light, and magnetic and electric fields. Hydrogels are widely reported for various applications. In fact, in recent years the research on hydrogel has been found to increase at an exponential rate, with around 8000 publications in 2021. In this article, the origin, history, theoretical modeling, synthesis, properties, classifications, characterization, and new applications of hydrogels have been discussed in detail with the citation of references till 2021.

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Smart Gels

Bag

Saxena

2014

Kirk-Othmer Encyclopedia of Chemical Technology

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Stimuli‐responsive gels are known as smart gels. Such gels respond adaptively to a variety of external stimulation. Different classes of smart gels, according to the name of the stimulus, are thermoresponsive, pH‐responsive, photoresponsive, electroresponsive, magnetoresponsive gels, chemically activated gels, and others. Such smart gel materials are discussed in this article along with their synthesis, characterization, properties, and various applications such as drug delivery systems, thermoresponsive cell culture dishes, microfluidic gel photovoltaics, etc. The advantages and disadvantages of electroactive gels have been discussed for their application as actuators. Microporous and superporous gels, microgels/nanogels, shape‐memory and self‐healing gels, and fullerene (C 60 )‐containing nanostructured smart polymers/gels are also depicted in this article. The state‐of‐the‐art research and development of smart gels along with the opportunities and challenges of this emerging field of research are highlighted in this article.

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Hydrogels in drug delivery: Progress and challenges

Cited by 3,305 publications

References 135 publications

pH-Triggered Release of Hydrophobic Molecules from Self-Assembling Hybrid Nanoscaffolds

pH-Triggered Release of Hydrophobic Molecules from Self-Assembling Hybrid Nanoscaffolds

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