Hydrogels of Dextran Containing Nonsteroidal Anti-Inflammatory Drugs as Pendant Agents

Feeney, Michelle; Giannuzzo, Maria; Paolicelli, Patrizia; Casadei, Maria Antonietta

doi:10.1080/10717540600740003

Cited by 16 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The structure was characterized by 1 H NMR (Figure ). The peak assignments were in good agreement with that reported by Feeney et al The relative ratios of peak areas for protons a, b, c, d, and e were found to be 2.0:2.9:3.8: 2.8:3.7 (theoretical values are 2:3:4:3:4). 1 H, 13 C, and 2D NMR data are included in Figure S1 of the Supporting Information.…”

Section: Resultssupporting

confidence: 91%

Biorenewable Thermoplastic Elastomeric Triblock Copolymers Containing Salicylic Acid‐Derived End‐Blocks and a Fatty Acid‐Derived Midblock

Wang

Ding

Yang

et al. 2015

Macro Chemistry & Physics

View full text Add to dashboard Cite

A sustainable triblock copolymer thermoplastic elastomer is developed containing a fatty acid‐derived midblock and salicylic acid‐derived endblocks. The rubbery midblock, poly(lauryl methacrylate), is chosen for its low glass transition temperature, hydrophobicity, and degradation resistance. Poly(acetylsalicylic ethyl methacrylate), derived from salicylic acid, abundantly encountered in plant products such as fruit and vegetable components, is developed as a biorenewable alternative for the glassy endblocks of the triblock copolymer. The acetylsalicylic ethyl methacrylate monomer offers advantages of the presence of carboxyl and hydroxyl groups, readily functionalized to acrylate or methacrylate groups, appropriate for controlled radical polymerization, and rigid aromatic rings which impart a high glass transition temperature to the polymer. The synthesis and characterization of poly(acetylsalicylic ethyl methacrylate‐block‐lauryl methacrylate‐block‐acetylsalicylic ethyl methacrylate) (ALA) triblock copolymers are presented. The ALA triblock copolymer exhibits microphase separated domains and is processable at elevated temperatures through compression molding. Tensile testing reveals elastomeric behavior at room temperature.

show abstract

Section: Resultssupporting

confidence: 91%

Biorenewable Thermoplastic Elastomeric Triblock Copolymers Containing Salicylic Acid‐Derived End‐Blocks and a Fatty Acid‐Derived Midblock

Wang

Ding

Yang

et al. 2015

Macro Chemistry & Physics

View full text Add to dashboard Cite

show abstract

“…On the other hand, hydrolysis of the polymer backbone can also regulate drug release, perhaps stimulating the release of a relatively altered drug analogue. For instance, methacrylate-functionalized non-steroidal anti-inflammatory drugs have been conjugated to methacrylic functionalized dextrans by means of UV radiation; a chemically modified drug analogue is released as the dextran hydrogel degrades [151,152].…”

Section: Advancing the Efficacy Of Hydrogels In Drug Delivery Applmentioning

confidence: 99%

A Review of Injectable Polymeric Hydrogel Systems for Application in Bone Tissue Engineering

et al. 2016

View full text Add to dashboard Cite

Biodegradable, stimuli-responsive polymers are essential platforms in the field of drug delivery and injectable biomaterials for application of bone tissue engineering. Various thermo-responsive hydrogels display water-based homogenous properties to encapsulate, manipulate and transfer its contents to the surrounding tissue, in the least invasive manner. The success of bioengineered injectable tissue modified delivery systems depends significantly on their chemical, physical and biological properties. Irrespective of shape and defect geometry, injectable therapy has an unparalleled advantage in which intricate therapy sites can be effortlessly targeted with minimally invasive procedures. Using material testing, it was found that properties of stimuli-responsive hydrogel systems enhance cellular responses and cell distribution at any site prior to the transitional phase leading to gelation. The substantially hydrated nature allows significant simulation of the extracellular matrix (ECM), due to its similar structural properties. Significant current research strategies have been identified and reported to date by various institutions, with particular attention to thermo-responsive hydrogel delivery systems, and their pertinent focus for bone tissue engineering. Research on future perspective studies which have been proposed for evaluation, have also been reported in this review, directing considerable attention to the modification of delivering natural and synthetic polymers, to improve their biocompatibility and mechanical properties.

show abstract

“…Therefore, some advanced delivery systems have been investigated to address the formulation limitations of currently available anti‐inflammatory drugs . The examined new pharmaceutical strategies include hydrogels, microparticles, nanofibers, lipid/polymeric vesicles, polymeric or lipid nanoparticles, micelles, nanocapsules, micro‐ or nano‐emulsions, and polymer‐drug conjugates, among others. In particular, nanotherapies have attracted considerable attention for the treatment of different acute and chronic inflammatory diseases, such as acute liver/lung injury, cardiovascular disease, neurodegenerative disorders, and inflammatory bowel disease .…”

Section: Introductionmentioning

confidence: 99%

Facile Engineering of Anti‐Inflammatory Nanotherapies by Host‐Guest Self‐Assembly

Yang

et al. 2020

ChemistrySelect

View full text Add to dashboard Cite

Anti‐inflammatory drugs have been broadly used for the treatment of different diseases, but many of them have low water‐solubility, thereby leading to poor bioavailability and limited clinical benefits. Herein we report host‐guest assembly of nanotherapies based on different hydrophobic anti‐inflammatory drugs, in which β‐cyclodextrin (β‐CD)‐conjugated polyethyleneimine (PEICDs) were used as host polymers. The spontaneous assembly and nanotherapy formation by PEICDs was first demonstrated using a nonsteroidal anti‐inflammatory drug indomethacin, showing high loading efficiencies and loading contents. Besides inclusion interactions, hydrogen‐bonding and electrostatic forces are responsible for effective host‐guest assembly. Moreover, this facile and robust approach can be generalized to other hydrophobic drugs. Due to the amorphous distribution of loaded drug molecules in nanotherapies, they can be rapidly and completely released, with the release rate relevant to the binding free energy between drug and β‐CD. Accordingly, this host‐guest assembly strategy is promising for developing effective anti‐inflammatory nanotherapies.

show abstract

Hydrogels of Dextran Containing Nonsteroidal Anti-Inflammatory Drugs as Pendant Agents

Cited by 16 publications

References 15 publications

Biorenewable Thermoplastic Elastomeric Triblock Copolymers Containing Salicylic Acid‐Derived End‐Blocks and a Fatty Acid‐Derived Midblock

Biorenewable Thermoplastic Elastomeric Triblock Copolymers Containing Salicylic Acid‐Derived End‐Blocks and a Fatty Acid‐Derived Midblock

A Review of Injectable Polymeric Hydrogel Systems for Application in Bone Tissue Engineering

Facile Engineering of Anti‐Inflammatory Nanotherapies by Host‐Guest Self‐Assembly

Contact Info

Product

Resources

About