Hydrogels of β-cyclodextrin crosslinked by acylated poly(ethylene glycol): Synthesis and properties

Cyclodextrin/dextran based hydrogels prepared by cross-linking with sodium trimetaphosphate

“…LC values also increase regularly with the ␤CD content and correspond to a Bzo occupancy rate of the ␤CD cavities around 50-65%. This estimate is in agreement with the results reported in the literature for ␤CD-based hydrogels where LC of ␤CD complexing agents are found to stand in a wide range, comprised between 0.2 and 18%, but are mainly controlled by the ␤CD content of the hydrogels (Cesteros et al, 2009;Glisoni et al, 2013;Hamcerencu et al, 2009;Machín et al, 2012;Rodriguez-Tenreiro et al, 2007;Thatiparti et al, 2010;Xu et al, 2010;Zhang et al, 2013). Fig.…”

“…Taking advantage of the chemical CD structure with many hydroxyl groups, different authors have reported synthesis of hydrogels using ␤CD as a cross-linker with poly(acrylic acid) (Kutyła et al, 2013) or ␤CD-based hydrogels using different crosslinkers such as epichlorohydrin (Machín, Isasi, & Vélaz, 2012;Zhang, Zhou, & Zhang, 2013), ethyleneglycol diglycidyl ether (Glisoni et al, 2013;Rodriguez-Tenreiro, Alvarez-Lorenzo, Rodriguez-Perez, Concheiro, & Torres-Labandeira, 2007), disubstituted poly(ethyleneglycol) (Cesteros, González-Teresa, & Katime, 2009), hexamethylenediisocyanate (Thatiparti, Shoffstall, & von Synthesis conditions and characterization of the hydrogels after purification and freeze-drying (P/O and P/C atomic ratios determined by XPS, and swelling ratio SR determined in pure water).…”

Cyclodextrin Complexation for Affinity‐Based Antibiotic Delivery

“…The most common pharmaceutical applications of CDm and their chemical derivatives are to enhance the aqueous solubility of the complexed species, to improve the aqueous stability, photostability, and bioavailability of complexed drugs and eventually to reduce side effects 3–5. The water solubility of CDs can limit their application towards drug delivery systems, therefore, CDm is frequently crosslinked with different reactants6, 7 or they can be incorporated into different polymer networks often resulting in a delay of drug release through drug‐ CDm complexation 8, 9. In the later case, the regulation of drug release depends on many different parameters such as mesh size of polymer network, affinity between drug and CDm molecules and the competition of the components in the environment 10, 11.…”

Sorption of 1–Naphthol on –Cyclodextrin–Poly(ethylene Glycol) hydrogels

“…The values reported for the sorption capacity of these networks are ranging between 105 and 106 mol/g at similar concentrations of 2-naphthol (5·10 -4 mol/L) in water, although 2-naphthol forms more stable inclusion complexes with -CD than 1-naphthol 16 and the sorption behavior can be affected. Our group 17 has studied de sorption of 1-naphthol on -CD hydrogels prepared by reaction with acylated poly(ethylene glycol) with a molar mass of 600 g/mol. These networks, linked by ester groups, and with different -CD/poly(ethylene glycol) ratios: 1/4, 1/6, 1/8 and 1/10; show a maximum sorption capacity of 82.8 mol/g for concentrations de 5.2·10 -5 mol/L of 1-naphthol.…”