Hydrogen breath test in patients with alcoholic liver disease: Evidence for bacterial overgrowth in the small intestine

Bode, Ch.; Kolepke, R; Schäfer, Katharina; Bode, J C

doi:10.1016/0168-8278(90)91369-8

Cited by 43 publications

(47 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…28 These results have been confirmed by Hauge and colleagues in alcoholic patients admitted to hospital for detoxification who underwent upper gastrointestinal endoscopy with gastric and duodenal biopsies for bacteriological culture. A high prevalence of bacterial overgrowth (Gram-positive aerobic cocci) in the upper gastrointestinal tract was found in alcoholic patients.…”

supporting

confidence: 70%

See 1 more Smart Citation

Review article: alcohol and gut microbiota ‐ the possible role of gut microbiota modulation in the treatment of alcoholic liver disease

Vassallo

Mirijello

Ferrulli

et al. 2015

Aliment Pharmacol Ther

101

View full text Add to dashboard Cite

show abstract

supporting

confidence: 70%

“…27 In a subsequent study, the same authors evaluated, by using hydrogen breath test, small intestine bacterial overgrowth (SIBO) in chronic alcoholics (n = 45) and in subjects without history of alcohol abuse (n = 60). 28 A significant higher prevalence of SIBO in alcoholics with respect to controls was found.…”

mentioning

confidence: 88%

Review article: alcohol and gut microbiota ‐ the possible role of gut microbiota modulation in the treatment of alcoholic liver disease

Vassallo

Mirijello

Ferrulli

et al. 2015

Aliment Pharmacol Ther

101

View full text Add to dashboard Cite

show abstract

“…On univariate analysis, various individual parameters of liver function were also not found to be significantly associated with the risk of SIBO. Other workers have shown SIBO to be more prevalent in alcoholic cirrhosis [9,17] compared to controls. But our study, which includes a larger number of patients with cirrhosis due to various causes, shows that SIBO is prevalent in cirrhosis due to any cause.…”

Section: Discussionmentioning

confidence: 98%

Frequency and Factors Associated with Small Intestinal Bacterial Overgrowth in Patients with Cirrhosis of the Liver and Extra Hepatic Portal Venous Obstruction

et al. 2009

View full text Add to dashboard Cite

Spontaneous bacterial peritonitis (SBP), a common complication of cirrhosis of liver, might result from translocation of bacteria from the small bowel. However, there is scanty data on frequency of small intestinal bacterial overgrowth (SIBO) in patients with cirrhosis of the liver. There are no data on SIBO in patients with extra-hepatic portal venous obstruction (EHPVO) in the literature. A total of 174 patients with cirrhosis of the liver, 28 with EHPVO and 51 healthy controls were studied for SIBO using glucose hydrogen breath test (GHBT). Persistent rise in breath hydrogen 12 ppm above basal (at least two readings) was considered diagnostic of SIBO. Of 174 patients (age 47.2 +/- 11.9 years, 80.5% male) with cirrhosis due to various causes, 67 (38.5%) were in Child's class A, 70 (40.2%) class B and 37 (21.7%) class C. Of the 174 patients with cirrhosis, 42 (24.14%) had SIBO as compared to 1 of 51 (1.9%) healthy controls (P < 0.0001). Patients with EHPVO had similar frequency of SIBO compared to healthy controls [2/28 (7.14%) vs 1/51 (1.97%), P = ns]. Frequency of SIBO in Child's A, B and C was comparable [13 (18.6%) vs 16 (23.9%) and 13 (35.1%), respectively; P = ns]. Presence of SIBO were not related to ascites, etiology of cirrhosis, and degree of liver dysfunction. SIBO is common in patients with cirrhosis of the liver. Patients with EHPVO do not have higher frequency of SIBO than healthy subjects. SIBO in cirrhosis is not related to the degree of derangement in liver function or of portal hypertension.

show abstract

“…Bacterial over growth was also reported in the duodenum of alcoholics (Hauge et al, 1997). In another study, the incidence of intestinal bacterial overgrowth was three times higher in alcoholics with ALD than that in control subjects with no history of alcohol abuse (Bode et al, 1993). These studies suggest that chronic alcohol abuse can promote bacterial growth in the intestine; however, further studies are required to answer the following questions.…”

Section: Alcohol and Intestinal Bacterial Growthmentioning

confidence: 91%

Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: Summary of a symposium

Purohit

Bode

et al. 2008

Alcohol

277

220

View full text Add to dashboard Cite

show abstract

Hydrogen breath test in patients with alcoholic liver disease: Evidence for bacterial overgrowth in the small intestine

Cited by 43 publications

References 0 publications

Review article: alcohol and gut microbiota ‐ the possible role of gut microbiota modulation in the treatment of alcoholic liver disease

Review article: alcohol and gut microbiota ‐ the possible role of gut microbiota modulation in the treatment of alcoholic liver disease

Frequency and Factors Associated with Small Intestinal Bacterial Overgrowth in Patients with Cirrhosis of the Liver and Extra Hepatic Portal Venous Obstruction

Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: Summary of a symposium

Contact Info

Product

Resources

About