Hydrogen peroxide-induced oxidative damage in peripheral blood lymphocytes from rats chronically treated with corticosterone: The protective effect of oxytocin treatment

Stanić, Dušanka; Plećaš-Solarović, Bosiljka; Petrović, Jelena; Bogavac-Stanojević, Nataša; Sopić, Miron; Kotur‐Stevuljević, Jelena; Ignjatović, Svetlana; Pešić, Vesna

doi:10.1016/j.cbi.2016.07.006

Cited by 29 publications

(21 citation statements)

References 47 publications

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“…This finding is in line with the known role of oxytocin in improving social and non-social behaviors, and dampening anxiety, stress and depression (Baribeau and Anagnostou, 2015; Carter, 2014; Feldman et al, 2016). It is also consistent with previous reports describing the oxytocin-corticosterone interplay in rodent models of both social (Burkett et al, 2016; Wang et al, 2012) and non-social- related stress (Cohen et al, 2010; Smith et al, 2016a; Stanic et al, 2016; Vilela et al, 2013). It will be interesting to investigate roles for L. reuteri in stress-induced corticosterone levels and animal behaviors.…”

Section: Discussionsupporting

confidence: 93%

“…An inverse relationship exists, in general, between systemic levels of oxytocin and stress-related hormones cortisol and corticosterone (Burkett et al, 2016; Cohen et al, 2010; Smith et al, 2016a; Stanic et al, 2016; Vilela et al, 2013; Wang et al, 2012). Finding that oral L. reuteri therapy increased circulating levels of oxytocin in our animal model, we theorized that L. reuteri associated with better maternal care and nursing behavior may also down-regulate stress levels in host animals.…”

Section: Resultsmentioning

confidence: 99%

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Microbial lysate upregulates host oxytocin

Varian

Poutahidis

DiBenedictis

et al. 2017

Brain, Behavior, and Immunity

120

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Neuropeptide hormone oxytocin has roles in social bonding, energy metabolism, and wound healing contributing to good physical, mental and social health. It was previously shown that feeding of a human commensal microbe Lactobacillus reuteri (L. reuteri) is sufficient to up-regulate endogenous oxytocin levels and improve wound healing capacity in mice. Here we show that oral L. reuteri-induced skin wound repair benefits extend to human subjects. Further, dietary supplementation with a sterile lysate of this microbe alone is sufficient to boost systemic oxytocin levels and improve wound repair capacity. Oxytocin-producing cells were found to be increased in the caudal paraventricular nucleus [PVN] of the hypothalamus after feeding of a sterile lysed preparation of L. reuteri, coincident with lowered blood levels of stress hormone corticosterone and more rapid epidermal closure, in mouse models. We conclude that microbe viability is not essential for regulating host oxytocin levels. The results suggest that a peptide or metabolite produced by bacteria may modulate host oxytocin secretion for potential public or personalized health goals.

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Section: Discussionsupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Microbial lysate upregulates host oxytocin

Varian

Poutahidis

DiBenedictis

et al. 2017

Brain, Behavior, and Immunity

120

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“…The results obtained in treatment C (+2000Al/−NMU) implies a greater genotoxic effect after 15 days of exposure that is irreversible and considerably greater than the effect of H 2 O 2 exposure [76,77]. A previous study reported that aluminum in the form of aluminum lactate intragastrically administered for 12 weeks could cause DNA fragmentation in the brain tissue of female Wistar rats when the genotoxic effect was assessed using agarose gel electrophoresis [78].…”

Section: Alkaline Electrophoresis Test In Individual Cells (Comet Assay)mentioning

confidence: 99%

Genotoxic Effects of Aluminum Chloride and Their Relationship with N-Nitroso-N-Methylurea (NMU)-Induced Breast Cancer in Sprague Dawley Rats

García-Alegría

Gómez-Álvarez

Anduro-Corona

et al. 2020

Toxics

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Recently, soluble forms of aluminum for human use or consumption have been determined to be potentially toxic due to their association with hepatic, neurological, hematological, neoplastic, and bone conditions. This study aims to assess the genotoxic effect of aluminum chloride on genomic instability associated with the onset of N-nitroso-N-methylurea (NMU)-induced breast cancer in Sprague Dawley rats. The dietary behavior of the rats was assessed, and the concentration of aluminum in the mammary glands was determined using atomic absorption spectroscopy. Genomic instability was determined in the histological sections of mammary glands stained with hematoxylin and eosin. Moreover, micronucleus in peripheral blood and comet assays were performed. The results of dietary behavior evaluation indicated no significant differences between the experimental treatments. However, aluminum concentration in breast tissues was high in the +2000Al/−NMU treatment. This experimental treatment caused moderate intraductal cell proliferation, lymph node hyperplasia, and serous gland adenoma. Furthermore, micronucleus and comet test results revealed that +2000Al/−NMU led to a genotoxic effect after a 10-day exposure and the damage was more evident after a 15-day exposure. Therefore, in conclusion, genomic instability is present and the experimental conditions assessed are not associated with breast cancer.

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“…Once exposure to stressor, specific pathways within the brain lead to activation of the hypothalamo-pituitary-adrenal (HPA) axis as well as central sympathetic outflow. This constitutes the stress response with the release of key peripheral mediators “glucocorticoids and catecholamines” [25]. In response to activation of the HPA axis, POMC-derived ACTH stimulates adrenal cortex to release GCs.…”

Section: The Impact Of Psychosocial Stress and Glucocorticoids On Bodmentioning

confidence: 99%

“…Also during early stage of liver regeneration [2, 21], increased cortisol secretion in response to stressful conditions mobilizes the metabolic energy to prepare the body for emergency situations. Persistent stress is also accompanied by an increase in cytokines [10, 11], oxidative stress, reactive oxygen species (ROS) [24] and increased reactive nitrogen species (RNS) production [25] which are known to interfere the regulatory mechanisms of liver regeneration.…”

Section: Introductionmentioning

confidence: 99%

Psychosocial-Stress, Liver Regeneration and Weight Gain: a Conspicuous Pathophysiological Triad

Ishtiaq

Khan

Arshad

2018

Cell Physiol Biochem

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Psychosocial stress alters several physiological parameters resulting in multiple disorders, particularly compromising the immune system thereby provoking various diseases including liver disorders. However, the plausible underlying mechanisms remain elusive. Recent literature provides mechanistic evidences of detrimental effects of psychosocial stress on physiology of different body organs including liver. The data of stress-induced pathophysiological changes in liver functions and obesity were systematically collected from PubMed, ScienceDirect and the Web of Science Databases published in English. Stress and glucocorticoids (GCs) control food intake and energy expenditure through appetite stimulators neuropeptide Y (NYP) and agouti-related protein (AgRP) in hypothalamus. Principle effectors of the activated hypothalamic-pituitary-adrenal (HPA) axis in response to psychosocial stress are proopiomelanocortin (POMC)-derived adrenocorticotropic hormone (ACTH) and GCs. Stress-induced GCs hyper-secretion triggers glucocorticoid receptor (GR)-dependent transcriptional factor, nuclear factor kappa B (NFκB), which interferes TNFα-IL6 and keap1-Nrf2 pathways in liver regeneration and obesity through fine-tuning of TNFα, IL6 and Nrf2 signaling. In this review, it is contrived upon existing evidence to put forward a model whereby exposure to life-stress has a prominent impact over weight gain and can alter the regenerative mode of a damaged liver through Keap1-Nrf2 and TNFa-IL6 pathways.

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Hydrogen peroxide-induced oxidative damage in peripheral blood lymphocytes from rats chronically treated with corticosterone: The protective effect of oxytocin treatment

Cited by 29 publications

References 47 publications

Microbial lysate upregulates host oxytocin

Microbial lysate upregulates host oxytocin

Genotoxic Effects of Aluminum Chloride and Their Relationship with N-Nitroso-N-Methylurea (NMU)-Induced Breast Cancer in Sprague Dawley Rats

Psychosocial-Stress, Liver Regeneration and Weight Gain: a Conspicuous Pathophysiological Triad

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