Hydrogen Peroxide Modulates the Proliferation/Quiescence Switch in the Liver During Embryonic Development and Posthepatectomy Regeneration

Bai, Hua; Zhang, Wei; Qin, Xu-Jun; Zhang, Tao; Wu, Hao; Liu, Jiangzheng; Hai, Chen

doi:10.1089/ars.2014.5960

Cited by 35 publications

(49 citation statements)

References 47 publications

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“…; Bai et al . ). Under hypoxic conditions, HIF1α is stabilized due to attenuation of an enzyme prolyl hydroxylase (Ivan et al .…”

Section: Discussionmentioning

confidence: 97%

“…HIF1, a heterodimer consisting of two subunits: hypoxia-responsive HIF1a (100-to 120-kDa) subunit and constitutively expressed subunit HIF1b (91-to 94-kDa), is a transcription factor that senses the cellular oxygen deficiency (Wang et al 1995). Under normal conditions, HIF1a is rapidly degraded by the ubiquitin-proteasome pathway (Huang et al 1998;Bai et al 2015). Under hypoxic conditions, HIF1a is stabilized due to attenuation of an enzyme prolyl hydroxylase (Ivan et al 2001;Jaakkola et al 2001).…”

Section: Discussionmentioning

confidence: 99%

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Tetramethylpyrazine inhibits CoCl₂‐induced neurotoxicity through enhancement of Nrf2/GCLc/GSH and suppression of HIF1α/NOX2/ROS pathways

Guan

et al. 2015

Journal of Neurochemistry

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Hypoxia-mediated neurotoxicity contributes to various neurodegenerative disorders, including Alzheimer's disease and multiple sclerosis. Tetramethylpyrazine (TMP), a major bioactive component purified from Ligusticum wallichii Franchat, exhibited potent neuroprotective effect. However, the mechanism of TMP-exerted neuroprotective effect against hypoxia was not clear. In the study, we investigated the mechanism of the neuroprotective effect of TMP against hypoxia induced by CoCl 2 in vitro and in vivo. The results showed that TMP could protect against CoCl 2 -induced neurotoxicity in PC12 cells and in rats, as evidenced by enhancement of cell viability in PC12 cells and improvement of learning and memory ability in rats treated with CoCl 2 . TMP could inhibit mitochondrial dysfunction, mitochondrial apoptotic molecular events, and thus apoptosis induced by CoCl 2 . TMP inhibited CoCl 2 -increased reactive oxygen species (ROS) level, which may contribute to hypoxia-related neurotoxicity induced by CoCl 2 . The antioxidant and neuroprotective activities of TMP involved two pathways: one was the enhancement of nuclear factor erythroid 2-related factor 2 (Nrf2)/catalytic subunit of cglutamylcysteine ligase-mediated regulation of GSH and the other was the inhibition of hypoxia-inducible factor 1 a/NADPH oxidase 2 (NOX2)-mediated ROS generation. These two pathways contributed to improvement of oxidative stress and thus the amelioration of apoptosis under hypoxic conditions. These results have appointed a new path toward the understanding of pathogenesis and TMP-related therapy of hypoxiarelated neurodegenerative diseases.

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“…; Bai et al . ). Under hypoxic conditions, HIF1α is stabilized due to attenuation of an enzyme prolyl hydroxylase (Ivan et al .…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Tetramethylpyrazine inhibits CoCl₂‐induced neurotoxicity through enhancement of Nrf2/GCLc/GSH and suppression of HIF1α/NOX2/ROS pathways

Guan

et al. 2015

Journal of Neurochemistry

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“…In particular, a transient elevation of H 2 O 2 is necessary to induce regenerative programs (Bai et al, 2015;Gauron et al, 2013;Love et al, 2013;Meda et al, 2016;Pirotte et al, 2015), enhance cell plasticity (Bigarella et al, 2014) and promote wound healing (Loo et al, 2012;Niethammer et al, 2009) as well as peripheral sensory axon growth after lesion (Meda et al, 2016;Rieger and Sagasti, 2011 it has been recently demonstrated that during zebrafish adult regeneration H 2 O 2 controls Shh expression (Meda et al, 2016). Appendage and organ regeneration are often presented as a replay of developmental programs.…”

Section: Introductionmentioning

confidence: 99%

Hydrogen peroxide (H2O2) controls axon pathfinding during zebrafish development

Gauron

Meda

Dupont

et al. 2016

Developmental Biology

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a b s t r a c tIt is now becoming evident that hydrogen peroxide (H 2 O 2 ), which is constantly produced by nearly all cells, contributes to bona fide physiological processes. However, little is known regarding the distribution and functions of H 2 O 2 during embryonic development. To address this question, we used a dedicated genetic sensor and revealed a highly dynamic spatio-temporal pattern of H 2 O 2 levels during zebrafish morphogenesis. The highest H 2 O 2 levels are observed during somitogenesis and organogenesis, and these levels gradually decrease in the mature tissues. Biochemical and pharmacological approaches revealed that H 2 O 2 distribution is mainly controlled by its enzymatic degradation. Here we show that H 2 O 2 is enriched in different regions of the developing brain and demonstrate that it participates to axonal guidance. Retinal ganglion cell axonal projections are impaired upon H 2 O 2 depletion and this defect is rescued by H 2 O 2 or ectopic activation of the Hedgehog pathway. We further show that ex vivo, H 2 O 2 directly modifies Hedgehog secretion. We propose that physiological levels of H 2 O 2 regulate RGCs axonal growth through the modulation of Hedgehog pathway.

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“…We also found in that study that inhibiting ROS production during tail regeneration resulted in impaired Wnt/β-catenin signalling and fgf20 expression, which are both required for tail regeneration. A role for elevated ROS levels during appendage and tissue regeneration has been described in a variety of organisms, including zebrafish, planarians, fruit flies, geckos and rats (Bai et al, 2015;Gauron et al, 2013;Khan et al, 2017;Pirotte et al, 2015;Santabárbara-Ruiz et al, 2015;Zhang et al, 2016). The finding that early embryos are also associated with sustained elevated ROS levels and that these elevated ROS levels also regulate growth factor signalling in development, suggests that, successful appendage regeneration is necessarily accompanied by a return to an embryonic-like redox state, which is permissive for growth factor signalling.…”

Section: Discussionmentioning

confidence: 99%

Elevated and sustained reactive oxygen species levels facilitate mesoderm formation during earlyXenopusdevelopment

Han

Chen

et al. 2017

Preprint

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Fertilisation triggers embryonic development culminating with the activation of a number of highly co-ordinated and evolutionarily conserved signalling pathways, which induce and pattern the mesoderm of the developing embryo. Previous studies in invertebrates have shown that hydrogen peroxide (H 2 O 2 ), a reactive oxygen species (ROS), can act as a signalling molecule for axis specification during early development.Using a HyPer transgenic Xenopus laevis line that expresses a H 2 O 2 -sensitive fluorescent protein sensor maternally, we recently found that fertilisation triggers a rapid increase in ROS production. Here we show that this increase in ROS levels is sustained throughout early embryogenesis, lasting until the tailbud stages. In addition we show that lowering ROS levels from the blastula stage through the gastrula stages via antioxidant treatments disrupts mesoderm formation. Furthermore, we show that attenuating ROS levels during the blastula / gastrula stages affects some, but not all, growth factor signalling pathways involved in mesoderm induction and patterning, including the PI3K/Akt, TGF-β/Nodal, and Wnt/β-catenin signalling pathways. These data suggest that sustained elevated ROS levels during the blastula and gastrula stages are essential for early vertebrate embryonic development, at least partly, through their roles in promoting growth factor signalling.

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Hydrogen Peroxide Modulates the Proliferation/Quiescence Switch in the Liver During Embryonic Development and Posthepatectomy Regeneration

Abstract: Endogenous H2O2 production is tightly regulated during liver development and regeneration. H2O2 constitutes an important trigger for the proliferation and quiescence transition in hepatocytes via the concentration-dependent activation of the ERK or p38 pathway.

Cited by 35 publications

References 47 publications

Tetramethylpyrazine inhibits CoCl₂‐induced neurotoxicity through enhancement of Nrf2/GCLc/GSH and suppression of HIF1α/NOX2/ROS pathways

Tetramethylpyrazine inhibits CoCl₂‐induced neurotoxicity through enhancement of Nrf2/GCLc/GSH and suppression of HIF1α/NOX2/ROS pathways

Hydrogen peroxide (H2O2) controls axon pathfinding during zebrafish development

Elevated and sustained reactive oxygen species levels facilitate mesoderm formation during earlyXenopusdevelopment

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Hydrogen Peroxide Modulates the Proliferation/Quiescence Switch in the Liver During Embryonic Development and Posthepatectomy Regeneration

Abstract: Endogenous H2O2 production is tightly regulated during liver development and regeneration. H2O2 constitutes an important trigger for the proliferation and quiescence transition in hepatocytes via the concentration-dependent activation of the ERK or p38 pathway.

Cited by 35 publications

References 47 publications

Tetramethylpyrazine inhibits CoCl2‐induced neurotoxicity through enhancement of Nrf2/GCLc/GSH and suppression of HIF1α/NOX2/ROS pathways

Tetramethylpyrazine inhibits CoCl2‐induced neurotoxicity through enhancement of Nrf2/GCLc/GSH and suppression of HIF1α/NOX2/ROS pathways

Hydrogen peroxide (H2O2) controls axon pathfinding during zebrafish development

Elevated and sustained reactive oxygen species levels facilitate mesoderm formation during earlyXenopusdevelopment

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Resources

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Tetramethylpyrazine inhibits CoCl₂‐induced neurotoxicity through enhancement of Nrf2/GCLc/GSH and suppression of HIF1α/NOX2/ROS pathways

Tetramethylpyrazine inhibits CoCl₂‐induced neurotoxicity through enhancement of Nrf2/GCLc/GSH and suppression of HIF1α/NOX2/ROS pathways