2021
DOI: 10.1016/j.cellsig.2020.109870
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Hydrogen sulfide guards myoblasts from ferroptosis by inhibiting ALOX12 acetylation

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Cited by 47 publications
(41 citation statements)
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“…For example, RSL3 induces protein expression and acetylation of ALOX12, while the addition of sodium hydrosulfide reduces ALOX12 acetylation and ferroptosis in mouse myoblasts and skeletal muscles. [ 85 ] Moreover, the activity of TP53 in ferroptosis is also regulated by acetylation, [ 86 ] highlighting that posttranslational modifications of proteins perform crucial roles in regulating ferroptosis.…”
Section: Lipid Peroxidation In Ferroptosismentioning
confidence: 99%
“…For example, RSL3 induces protein expression and acetylation of ALOX12, while the addition of sodium hydrosulfide reduces ALOX12 acetylation and ferroptosis in mouse myoblasts and skeletal muscles. [ 85 ] Moreover, the activity of TP53 in ferroptosis is also regulated by acetylation, [ 86 ] highlighting that posttranslational modifications of proteins perform crucial roles in regulating ferroptosis.…”
Section: Lipid Peroxidation In Ferroptosismentioning
confidence: 99%
“…Acetylation absence in the mouse p53 K98 site and on other positions in the DNA-binding domain can result in the loss of tumor suppression functions in xenografts and ferroptosis ( Wang et al, 2016 ). Another study reported that RSL3 promotes the protein expression and acetylation of ALOX12, the key protein in initiating membrane phospholipid oxidation ( Wang Y. et al, 2021 ). Indirect regulation is also observable.…”
Section: Ferroptosis and Epigeneticsmentioning
confidence: 99%
“…Recently, studies showed the protective role of H 2 S is associated with ferroptosis inhibition. Wang and Chen et al identified H 2 S restrains ferroptosis via inhibiting ALOX12 acetylation and regulating the xCT (the functional submit of the Xc − system) stability Wang et al, 2021c). H 2 S donor GYY4137 treatment alleviates ferroptosis to attenuate acute lung injury (Li et al, 2021).…”
Section: Discussionmentioning
confidence: 99%