Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review

Zhang, Heng; Huang, Yaqian; Chen, Selena; Tang, Chaoshu; Wang, Guang; Du, Junbao; Jin, Hongfang

doi:10.1016/j.jare.2020.02.013

Cited by 56 publications

(37 citation statements)

References 77 publications

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“…OT, CSE and CBS are expressed in insulin-sensitive tissues [ 95 , 96 ]. H 2 S is endogenously released by skeletal muscle, liver, adipose and islet-β-cells [ 97 ]; the OT and OTR are also present in islet-β-cells and skeletal muscle cells [ 98 ]. OT has been reported to increase glucose uptake in cardiomyocytes via PI3K signaling [ 96 ]; exogenous H 2 S administration restored blood glucose levels in the previously mentioned CSEko mice, and was associated with an upregulation of cardiac OTR [ 19 ].…”

Section: Chronic Cardiovascular Diseasementioning

confidence: 99%

The Interaction of the Endogenous Hydrogen Sulfide and Oxytocin Systems in Fluid Regulation and the Cardiovascular System

et al. 2020

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The purpose of this review is to explore the parallel roles and interaction of hydrogen sulfide (H2S) and oxytocin (OT) in cardiovascular regulation and fluid homeostasis. Their interaction has been recently reported to be relevant during physical and psychological trauma. However, literature reports on H2S in physical trauma and OT in psychological trauma are abundant, whereas available information regarding H2S in psychological trauma and OT in physical trauma is much more limited. This review summarizes recent direct and indirect evidence of the interaction of the two systems and their convergence in downstream nitric oxide-dependent signaling pathways during various types of trauma, in an effort to better understand biological correlates of psychosomatic interdependencies.

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Section: Chronic Cardiovascular Diseasementioning

confidence: 99%

The Interaction of the Endogenous Hydrogen Sulfide and Oxytocin Systems in Fluid Regulation and the Cardiovascular System

et al. 2020

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“…Moreover, metabolomic studies indicate that H 2 S can stimulate the activity of multiple Krebs cycle enzymes [ 56 , 58 ]. H 2 S was also found to upregulate glucose uptake in various cell types [ 171 , 172 , 173 , 174 ]; this may be very important to support the high glucose utilization of the cancer cell. Multiple metabolomic studies and genome wide gene expression studies [ 56 , 58 , 174 ] suggest that endogenously produced H 2 S plays a role in the reprogramming of the pyrimidine and purine metabolism, amino acid metabolism, nicotinate and nicotinamide metabolism, fatty acid metabolism, glutamate metabolism, the urea cycle, and several other pathways.…”

Section: Additional Mitochondrial Roles Of H 2 mentioning

confidence: 99%

Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells

Szabó

2021

Cells

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Hydrogen sulfide (H2S) has a long history as toxic gas and environmental hazard; inhibition of cytochrome c oxidase (mitochondrial Complex IV) is viewed as a primary mode of its cytotoxic action. However, studies conducted over the last two decades unveiled multiple biological regulatory roles of H2S as an endogenously produced mammalian gaseous transmitter. Cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST) are currently viewed as the principal mammalian H2S-generating enzymes. In contrast to its inhibitory (toxicological) mitochondrial effects, at lower (physiological) concentrations, H2S serves as a stimulator of electron transport in mammalian mitochondria, by acting as an electron donor—with sulfide:quinone oxidoreductase (SQR) being the immediate electron acceptor. The mitochondrial roles of H2S are significant in various cancer cells, many of which exhibit high expression and partial mitochondrial localization of various H2S producing enzymes. In addition to the stimulation of mitochondrial ATP production, the roles of endogenous H2S in cancer cells include the maintenance of mitochondrial organization (protection against mitochondrial fission) and the maintenance of mitochondrial DNA repair (via the stimulation of the assembly of mitochondrial DNA repair complexes). The current article overviews the state-of-the-art knowledge regarding the mitochondrial functions of endogenously produced H2S in cancer cells.

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“…There is currently a scarcity of studies interrogating the interaction of Acarbose with H 2 S. This presents a potentially fruitful area of novel research as H 2 S is already known to modulate insulin signalling and whole-animal glucose metabolism across tissues, cellular processes that appear intimately linked with longevity [ 141 ]. As with other signalling pathways, the effects of H 2 S are complex, with independent studies reporting either protective or deleterious effects [ 142 ]. The endogenous production of H 2 S in adipose cells was first described by Feng et al [ 143 ] who showed that elevated CSE expression and H 2 S production was correlated with insulin resistance in rats, suggestive of a deleterious diabetic phenotype associated with H 2 S expression in adipocytes.…”

Section: H 2 S and Ageingmentioning

confidence: 99%

Hydrogen sulfide in ageing, longevity and disease

Wilkie

Borland

Carter

et al. 2021

Biochemical Journal

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Hydrogen sulfide (H2S) modulates many biological processes, including ageing. Initially considered a hazardous toxic gas, it is now recognised that H2S is produced endogenously across taxa and is a key mediator of processes that promote longevity and improve late-life health. In this review, we consider the key developments in our understanding of this gaseous signalling molecule in the context of health and disease, discuss potential mechanisms through which H2S can influence processes central to ageing and highlight the emergence of novel H2S-based therapeutics. We also consider the major challenges that may potentially hinder the development of such therapies.

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Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review

Abstract: Graphical abstract

Cited by 56 publications

References 77 publications

The Interaction of the Endogenous Hydrogen Sulfide and Oxytocin Systems in Fluid Regulation and the Cardiovascular System

The Interaction of the Endogenous Hydrogen Sulfide and Oxytocin Systems in Fluid Regulation and the Cardiovascular System

Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells

Hydrogen sulfide in ageing, longevity and disease

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