Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE-/- mice corpus cavernosum microcirculation

Olivencia, Miguel A; Esposito, Erika C.; Brancaleone, Vincenzo; Castaldo, Sigismondo; Cirino, Giuseppe; Pérez‐Vizcaíno, Francisco; Sorrentino, Raffaella; Bianca, Roberta d’Emmanuele di Villa; Mitidieri, Emma

doi:10.1016/j.phrs.2023.106834

Cited by 6 publications

(6 citation statements)

References 51 publications

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“…Mostafa et al [82] found that NaHS (30 mg/kg) increased th levels of NO in the cavernous tissues of rats, which is consistent with the aforementione findings. However, knockout of CSE significantly reduced the levels of p-eNOS and N in rat corpus cavernosum tissues [83] (Figure 4). These findings suggest that H2S regulat penile erectile function by promoting the production of NO.…”

Section: Mechanisms Of H2s In Regulating Penile Erectionmentioning

confidence: 95%

“…For example, treatment with L-Cys (1 µM-1 mM) and NaHS (1 µM-1 mM) increases cGMP levels in HCC, whereas administration with ODQ, an inhibitor of sGC, reverses this effect [114]. The decrease in H 2 S content in CSE-KO mice weakens the redox state of sGC, thereby downregulating cGMP in the penis [83], suggesting that H 2 S promotes penile erection by upregulating cGMP through other pathways.…”

Section: Mechanisms Of H2s In Regulating Penile Erectionmentioning

confidence: 99%

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Therapeutic Potential of Hydrogen Sulfide in Reproductive System Disorders

Sun,

Mao,

Xie

et al. 2024

Biomolecules

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Hydrogen sulfide (H2S), previously regarded as a toxic exhaust and atmospheric pollutant, has emerged as the third gaseous signaling molecule following nitric oxide (NO) and carbon monoxide (CO). Recent research has revealed significant biological effects of H2S in a variety of systems, such as the nervous, cardiovascular, and digestive systems. Additionally, H2S has been found to impact reproductive system function and may have therapeutic implications for reproductive disorders. This paper explores the relationship between H2S and male reproductive disorders, specifically erectile dysfunction, prostate cancer, male infertility, and testicular damage. Additionally, it examines the impact of H2S regulation on the pathophysiology of the female reproductive system, including improvements in preterm birth, endometriosis, pre-eclampsia, fetal growth restriction, unexplained recurrent spontaneous abortion, placental oxidative damage, embryo implantation, recovery of myometrium post-delivery, and ovulation. The study delves into the regulatory functions of H2S within the reproductive systems of both genders, including its impact on the NO/cGMP pathway, the activation of K+ channels, and the relaxation mechanism of the spongy smooth muscle through the ROCK pathway, aiming to broaden the scope of potential therapeutic strategies for treating reproductive system disorders in clinical settings.

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Section: Mechanisms Of H2s In Regulating Penile Erectionmentioning

confidence: 95%

Section: Mechanisms Of H2s In Regulating Penile Erectionmentioning

confidence: 99%

Therapeutic Potential of Hydrogen Sulfide in Reproductive System Disorders

Sun,

Mao,

Xie

et al. 2024

Biomolecules

View full text Add to dashboard Cite

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“…Meng et al (39) showed that eNOS notably increased the production of NO from L-arginine by 5 times in more than rat CC tissues treated with NaHS (1 mM), suggesting that H 2 S enhanced the activity of eNOS. Knockout of CSE may not alter total eNOS levels but may remarkably reduce the levels of its active form p-eNOS (16).…”

Section: Regulation Of Mechanisms Underlying Penile Erectionmentioning

confidence: 96%

Role of hydrogen sulfide in the male reproductive system

Song,

Mao,

Zhong

et al. 2024

Front. Endocrinol.

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As an important gas signaling molecule, hydrogen sulfide (H2S) affects multiple organ systems, including the nervous, cardiovascular, digestive, and genitourinary, reproductive systems. In particular, H2S not only regulates female reproductive function but also holds great promise in the treatment of male reproductive diseases and disorders, such as erectile dysfunction, prostate cancer, varicocele, and infertility. In this review, we summarize the relationship between H2S and male reproductive organs, including the penis, testis, prostate, vas deferens, and epididymis. As lower urinary tract symptoms have a significant impact on penile erection disorders, we also address the potential ameliorative effects of H2S in erectile dysfunction resulting from bladder disease. Additionally, we discuss the regulatory role of H2S in cavernous smooth muscle relaxation, which involves the NO/cGMP pathway, the RhoA/Rho-kinase pathway, and K+ channel activation. Recently, various compounds that can alleviate erectile dysfunction have been reported to be at least partly dependent on H2S. Therefore, understanding the role of H2S in the male reproductive system may help develop novel strategies for the clinical treatment of male reproductive system diseases.

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“…In diabetic or eNOS-deficient mice, BAY 41-2272 increases relaxation induced by activation of the NO-cGMP pathway ( Nunes et al, 2015 ). A recent study highlighted that riociguat (BAY 63-2521) promotes concentration-dependent relaxation in the corpora cavernosa of mice ( Olivencia et al, 2023 ). Notably, in 2013, the approved riociguat for treating pulmonary hypertension, underlining its therapeutic potential in conditions of low cGMP bioavailability.…”

Section: An Overview Of the Effects Of Sgc Stimulators And Activators...mentioning

confidence: 99%

“…Regarding sGC activators, cinaciguat (BAY 58–2667) induces concentration-dependent relaxation in corpora cavernosa of mice, accompanied by an increase in cGMP production ( Decaluwé et al, 2017 ; de Oliveira et al, 2023 ; Olivencia et al, 2023 ). Furthermore, BAY 60-2770 promotes concentration-dependent relaxation in rabbit corpora cavernosa and exhibits potent erectile activity in rats ( Lasker et al, 2013 ).…”

Section: An Overview Of the Effects Of Sgc Stimulators And Activators...mentioning

confidence: 99%

Soluble guanylate cyclase stimulators and activators: new horizons in the treatment of priapism associated with sickle cell disease

Pereira,

Silveira,

Calmasini

et al. 2024

Front. Pharmacol.

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Priapism, defined as a prolonged and often painful penile erection occurring without sexual stimulation or desire, is a common complication in sickle cell disease (SCD), affecting up to 48% of male patients. This condition presents significant clinical challenges and can lead to erectile dysfunction if not properly managed. Current pharmacological treatments for SCD-related priapism are primarily reactive rather than preventative, highlighting a gap in effective medical intervention strategies. A critical factor in developing priapism is the reduced basal bioavailability of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) in erectile tissues. New prevention strategies should ideally target the underlying pathophysiology of the disease. Compounds that stimulate and activate soluble guanylate cyclase (sGC) emerge as potential therapeutic candidates since these compounds have the property of inducing cGMP production by sGC. This review explores the potential of sGC stimulators and activators in treating priapism associated with SCD. We discuss the advantages of these agents in the face of the challenging pathophysiology of SCD. Additionally, the review underscores the impact of intravascular hemolysis and oxidative stress on priapism pathophysiology in SCD, areas in which sGC stimulators and activators may also have beneficial therapeutic effects.

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Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE-/- mice corpus cavernosum microcirculation

Cited by 6 publications

References 51 publications

Therapeutic Potential of Hydrogen Sulfide in Reproductive System Disorders

Therapeutic Potential of Hydrogen Sulfide in Reproductive System Disorders

Role of hydrogen sulfide in the male reproductive system

Soluble guanylate cyclase stimulators and activators: new horizons in the treatment of priapism associated with sickle cell disease

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