Hydrogen Sulfide-Specific and NIR-Light-Controllable Synergistic Activation of Fluorescent Theranostic Prodrugs for Imaging-Guided Chemo-Photothermal Cancer Therapy

Abstract

Citation denotes calendar and volume year of first online publication.

Smart nanomaterials for cancer diagnosis and treatment

“…Reduces the in vivo tumor growth and shows good cyto- and hemo-compatibility to AT1 and blood cells, respectively [ 104 ] Hydrogen peroxide Gold nanovesicles Tirapazamine Stable in water, cell culture media, and plasma of rat up to 3 weeks 4T1 Breast cancer cells Upon H 2 O 2 encounter, cargo releases the drugs at tumor site in self-accelerating manner and exhibited tumor inhibition in breast tumor-bearing mice [ 105 ] Hydrogen peroxide Nanoemulsion composed of perfluoropolyether, catalase and photosensitizer IR780 Near-infrared light activatable photosensitizer IR780 No change in diameter or precipitation in cell culture media after 48 h incubation at 25 °C and 37 °C. Can be stored at 4 °C for 15 months OVCAR-3 Ovarian cancer cells Nanoplatform produces singlet oxygen upon light excitation and upon near-infrared light activation, nanopaltform exhibit cancer cells killing ability by photodynamic therapy in hypoxic tumor [ 106 ] Hydrogen sulfide Nanoprodrug composed of lauric acid, mPEG, lecithin BSO-DOX Doxorubicin Fluorescent prodrug possesses colorectal cancer specific photo-controllable synergistic therapeutic effect HCT116 human colorectal cancer cells Enabled the photothermal ablation of tumor and activate drug release in presence of H 2 S. HCT116 mice tumor has also been suppressed efficiently with high specificity [ 107 ] Hydrogen sulfide Anethole dithiolethione (ADT)-loaded magnetic nanoliposome (AML) Hydrogen sulfide bubble ADT transform the conventional liposome to a contrast agent where hydrogen sulfide bubbles have both diagnostic and therapeutic property HepG2 liver cancer cells In external magnetic field nanosized AML can be converted to microsized hydrogen sulfide bubble, which can be imaged by ultrasound imaging and can ablate tumor cells when exposed to high acoustic intensity [ 108 ] …”

A Highly Stable Two-Photon Ratiometric Fluorescence Probe for Real-Time Biosensing and Imaging of Nitric Oxide in Brain Tissues and Larval Zebrafish

“…Fluorescent methods have attracted great attention because of their unique advantages in non-invasive and realtime sensing and imaging of biological samples. [28][29][30][31] The fluorescent probes currently used for NO detection were mostly organic fluorescent molecules based on o-phenylenediamine, 32 which usually suffered from the poor water solubility and photobleaching. [32][33] It is essential to develop a fluorescence analytical method for real-time bioimaging and quantification of NO in living cells with high stability and selectivity.…”

Nanozyme-Triggered Cascade Reactions from Cup-Shaped Nanomotors Promote Active Cellular Targeting

“…Nanocarriers have recently attracted great attention from diagnostic sensing to drug delivery owing to their unique advantages, for instance, high cargo payload, prolonged systemic circulation, and enhanced permeability and retention (EPR) effect [1][2][3][4]. Recently, with the merits of operational flexibility, noninvasiveness, low toxicity, and high spatiotemporal resolution, nanocarrier-based phototherapies have become an innovative strategy to achieve satisfactory therapeutic outcomes [5][6][7][8][9][10][11][12]. However, the therapeutic efficacy may be discounted due to the intrinsic limitations of monomodal therapy, for instance, the nonselectivity and strong laser intensity of photothermal therapy (PTT), as well as the hypoxic tumor microenvironment and short half-life time and limited diffusion distance of photoactivated singlet oxygen ( 1 O 2 ) for photodynamic therapy (PDT) [13].…”