Hydrolyzed Conchiolin Protein (HCP) Extracted from Pearls Antagonizes both ET-1 and α-MSH for Skin Whitening

Yang, Shan; Wang, Zhekun; Hu, Yunwei; Zong, Kaile; Zhang, Xingjiang; Kang, Hui; Wang, Pan; Go, Yuyo; Chan, Xi Hui Felicia; Wu, Jianxin; Huang, Qing

doi:10.3390/ijms24087471

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…Other agents which acts as direct ET-1 inhibitors are being prospected as potential treatments for pigmentary disorders. 36 , 37 To date, no specific topical ERB blockers are available, while potent ERA antagonist (eg, bosentana) have no role in melanogenesis.…”

Section: Discussionmentioning

confidence: 99%

Expression of Endothelin-1, Endothelin Receptor-A, and Endothelin Receptor-B in facial melasma compared to adjacent skin

da Silva,

Miot,

Grassi

et al. 2023

CCID

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Background/Objectives Although melasma is highly prevalent, its pathogenesis is not yet fully understood. In the skin, endothelin-1 (ET-1) is primarily produced by keratinocytes in response to UVB exposure, which is mediated by an increase in IL-1α or reactive oxygen species. ET-1 plays a role in melanogenesis by binding to specific receptor B (ERB) or receptor A (ERA). However, the expression of ET-1, ERA, and ERB in melasma has not been systematically investigated. The objective of this study was to evaluate the expression of ET-1, ERA, and ERB in facial melasma compared to the adjacent unaffected skin. Methods Cross-sectional study, with 40 skin samples (20: facial melasma; 20: adjacent unaffected skin) from women with facial melasma without treatment for 30 days except for sunscreen. A triple staining immunofluorescence technique was performed for anti-vimentin, DAPI, plus one of the following antibodies: (a) anti-ET1, (b) anti-ERA; (c) anti-ERB. Interfollicular areas on the slides of each topography (melasma; unaffected skin) were photographed in triplicate under confocal laser microscopy. The mean staining intensities of the image histograms (0–255 pixels intensity) were estimated for different types of cells (suprabasal keratinocytes, basal layer, and upper dermis) and were blindly compared between topographies. Results The mean (SD) age of the participants was 44.9 (9.2). The expression of ET-1 was increased in the whole epidermis with melasma when compared to the adjacent skin, being 32.8% (CI95% 14.7%–52.6%) higher in the spinous layer (p=0.013), 30.4% (CI95% 13.7%–47.9%) higher in the basal layer (p=0.014), and 29.7% (CI95% 11.4%–49.7%) higher in the melanocytes (p=0.006). There was no noticeable expression of ET-1 within the cells on the upper dermis. Neither ERA nor ERB resulted in differential epidermal expression between melasma and unaffected skin (p≥0.1). Conclusion ET-1 is expressed more intensely on the epidermis from the skin with facial melasma compared to the unaffected adjacent skin.

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Section: Discussionmentioning

confidence: 99%

Expression of Endothelin-1, Endothelin Receptor-A, and Endothelin Receptor-B in facial melasma compared to adjacent skin

da Silva,

Miot,

Grassi

et al. 2023

CCID

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“…Conchiolin is a tough, insoluble protein secreted by mollusks, forming a major organic component of the shell with deposited calcium carbonate. Hydrolyzed conchiolin protein, obtained from pearl shells, is a frequently used cosmetic ingredient in hair and skin conditioning products [ 91 , 245 ]. Latire et al analyzed shell extracts derived from the marine bivalve Pecten maximus [ 92 ].…”

Section: Adhesive/extracellular Matrix Proteinsmentioning

confidence: 99%

Bridging Nature and Engineering: Protein-Derived Materials for Bio-Inspired Applications

Nawaz,

Gu,

Gibbons

et al. 2024

Biomimetics

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The sophisticated, elegant protein-polymers designed by nature can serve as inspiration to redesign and biomanufacture protein-based materials using synthetic biology. Historically, petro-based polymeric materials have dominated industrial activities, consequently transforming our way of living. While this benefits humans, the fabrication and disposal of these materials causes environmental sustainability challenges. Fortunately, protein-based biopolymers can compete with and potentially surpass the performance of petro-based polymers because they can be biologically produced and degraded in an environmentally friendly fashion. This paper reviews four groups of protein-based polymers, including fibrous proteins (collagen, silk fibroin, fibrillin, and keratin), elastomeric proteins (elastin, resilin, and wheat glutenin), adhesive/matrix proteins (spongin and conchiolin), and cyanophycin. We discuss the connection between protein sequence, structure, function, and biomimetic applications. Protein engineering techniques, such as directed evolution and rational design, can be used to improve the functionality of natural protein-based materials. For example, the inclusion of specific protein domains, particularly those observed in structural proteins, such as silk and collagen, enables the creation of novel biomimetic materials with exceptional mechanical properties and adaptability. This review also discusses recent advancements in the production and application of new protein-based materials through the approach of synthetic biology combined biomimetics, providing insight for future research and development of cutting-edge bio-inspired products. Protein-based polymers that utilize nature’s designs as a base, then modified by advancements at the intersection of biology and engineering, may provide mankind with more sustainable products.

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Effects of Different Extraction Methods on Biological Activities of Pearl Powder Extracts

Wang,

An,

Lei

et al. 2024

Chemistry Africa

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Hydrolyzed Conchiolin Protein (HCP) Extracted from Pearls Antagonizes both ET-1 and α-MSH for Skin Whitening

Cited by 6 publications

References 35 publications

Expression of Endothelin-1, Endothelin Receptor-A, and Endothelin Receptor-B in facial melasma compared to adjacent skin

Expression of Endothelin-1, Endothelin Receptor-A, and Endothelin Receptor-B in facial melasma compared to adjacent skin

Bridging Nature and Engineering: Protein-Derived Materials for Bio-Inspired Applications

Effects of Different Extraction Methods on Biological Activities of Pearl Powder Extracts

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