Hydrolyzed proteins from herring and salmon rest raw material contain peptide motifs with angiotensin-I converting enzyme inhibitors and resulted in lower urine concentrations of protein, cystatin C and glucose when fed to obese Zucker fa/fa rats

Drotningsvik, Aslaug; Pampanin, Daniela M.; Šližytė, Rasa; Carvajal, Ana Karina; Høgøy, Ingmar; Remman, Tore; Gudbrandsen, Oddrun Anita

doi:10.1016/j.nutres.2018.01.001

Cited by 10 publications

(8 citation statements)

References 43 publications

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“…Consequently, peptides with renin or ACE inhibiting properties may lower blood pressure by reducing the production of angiotensin II. Motifs with ACE inhibiting activities have been identified in muscles and residuals from fish (17)(18)(19)(20), and in vitro inhibition of ACE and/or renin activities has been observed for proteins from muscles, viscera, skin and other residuals from several fish species including cod (12,13,15,19,20,51,52). However in the present study, after trypsin digestion, neither HBS nor casein inhibited the in vitro renin activity, and the ACE IC50 value of the HBS protein powder was significantly higher (i.e.…”

Section: Discussioncontrasting

confidence: 74%

“…Angiotensinogen is cleaved by renin to the biologically inactive angiotensin I, which is then converted to the active vasoconstrictor angiotensin II by angiotensin-converting enzyme (ACE) (16). Motifs with ACE inhibiting activity in vitro have been identified in fish fillet and residuals including skin and backbone (171 [8][9][10][11][12][13][14][15][16][17][18][19][20]. Other nutrients found in fish may also affect blood pressure.…”

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Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats

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Oterhals

Leh

et al. 2022

Food & Nutrition Research

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Background: Documentation of health effects of residuals after fish filleting may motivate both consumers and producers to increase the use of this under-utilised protein source. Objectives: The primary objective of the present study was to investigate the effects of a diet containing residuals from Atlantic cod (Gadus morhua) filleting on the development of high blood pressure in obese Zucker fa/fa rats, which spontaneously develop hypertension and proteinuria. The secondary objectives were to investigate any changes in kidney morphology, kidney function and organ damage, and to determine the potential inhibition of cod residuals on renin and angiotensin-converting enzyme (ACE) activities in vitro. Methods: Male rats were fed diets containing protein powder prepared from head, backbone and skin fraction (HBS, n = 6) from Atlantic cod as 25% of total protein with the remaining 75% as casein, or casein as the sole protein source (Control group, n = 6) for 4 weeks. Blood pressure was measured on day 0, 14 and 26. Kidneys were analysed morphologically, and markers for renal function and organ damage were analysed biochemically. Results: The HBS diet attenuated the blood pressure increase compared to the Control group, but kidney damage and dysfunction were similar between the two groups. Conclusion: A diet containing a protein powder consisting of HBS fraction from cod attenuated the blood pressure increase in obese Zucker fa/fa rats, without preventing kidney damage.

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confidence: 74%

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confidence: 99%

Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats

Vildmyren

Oterhals

Leh

et al. 2022

Food & Nutrition Research

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“…The authors linked the observed effects to the bioactive motives present in the different fish protein hydrolysates. 16 The same 2 fish protein hydrolysates were later reported to contain several peptide sequences with possible angiotensin-1 converting enzyme (ACE)-inhibiting activities and to beneficially alter the urine concentrations of glucose, protein, and cystatin C. 43…”

Section: Studies With Fish Protein Hydrolysatesmentioning

confidence: 99%

Fish–derived proteins and their potential to improve human health

2019

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Emerging evidence from studies evaluating the effect of lean fish consumption in humans suggests that proteins from fish have several beneficial metabolic effects. Rest, or waste, material from the fishing industry contains high-quality proteins, and utilization of this material offers novel possibilities for the development of protein-containing products that might be beneficial for human consumption. Fish-derived peptides containing bioactive amino acid sequences suggested to beneficially influence pathways involved in body composition, hypertension, lipid profile, and regulation of glucose metabolism are of particular interest, although the results of published studies are conflicting. This review aims to summarize current knowledge from animal studies and clinical interventions in humans evaluating the effects of lean fish, fish proteins, and fish-derived peptides on outcomes related to metabolic health. Fish proteins have a high content of taurine, and animal trials suggest that taurine mediates some of the beneficial effects observed thus far, although the mechanisms by which fish peptides exert their action are not yet elucidated. At this time, the literature is inconsistent, and there is insufficient mechanistic evidence to support a beneficial effect of fish-derived peptides on metabolic health.

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“…A persistent high blood glucose concentration over time may damage the glomeruli and thus the capacity of the kidneys to filter the blood; therefore, further studies on the effects of fish proteins on kidney function are warranted. Little is known about the effects of fish proteins on markers of kidney function in this animal model of human obesity, but fat-free protein hydrolysates from herring and salmon by-products ( 43 ) as well as salmon fillet ( 44 ) beneficially affected markers of kidney function in obese Zucker fa/fa rats.…”

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Dietary intake of cod protein beneficially affects concentrations of urinary markers of kidney function and results in lower urinary loss of amino acids in obese Zucker fa/fa rats

et al. 2018

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Obesity increases the risk for developing kidney disease, and protection of kidneys through changes in diet should be investigated. Fish intake has been associated with reduced risk of developing kidney disease; therefore, we wanted to investigate whether cod protein intake could prevent or delay the development of kidney damage in an obese rat model that spontaneously develops proteinuria and focal segmental glomerulosclerosis. The aim of the study was to investigate any effects of cod protein intake on established markers of kidney function, amino acid composition, protein utilisation and growth in obese Zucker fa/fa rats in the early stage of decreased renal function. Male obese Zucker fa/fa rats (HsdOla:Zucker-Lepr) were fed cod muscle proteins in an amount corresponding to 25 % of dietary protein, with the remaining protein from a casein/whey mixture (COD diet). A control group was fed a diet with a casein/whey mixture as the only protein source (CAS diet). The intervention started when rats were 9-10 weeks old, and the rats were fed these diets for 4 weeks. At the end of the study, rats fed the COD diet had lower urine concentration of cystatin C, T-cell immunoglobulin mucin-1 (TIM-1), amino acids, carbamide, uric acid and ammonium and higher concentrations of creatine, trimethylamine N-oxide, 1-methylhistidine and 3-methylhistidine, lower kidney concentration of TIM-1 and showed better growth when compared with the CAS group. To conclude, cod protein may have the potential to delay the development of kidney damage in young obese Zucker rats and to improve protein utilisation and growth.

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Hydrolyzed proteins from herring and salmon rest raw material contain peptide motifs with angiotensin-I converting enzyme inhibitors and resulted in lower urine concentrations of protein, cystatin C and glucose when fed to obese Zucker fa/fa rats

Cited by 10 publications

References 43 publications

Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats

Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats

Fish–derived proteins and their potential to improve human health

Dietary intake of cod protein beneficially affects concentrations of urinary markers of kidney function and results in lower urinary loss of amino acids in obese Zucker fa/fa rats

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