2024
DOI: 10.1021/acs.jpcb.4c00405
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Hydrophobic Clusters Regulate Surface Hydration Dynamics of Bacillus subtilis Lipase A

Afnan M. Jaufer,
Adam Bouhadana,
Gail E. Fanucci

Abstract: The surface hydration diffusivity of Bacillus subtilis Lipase A (BSLA) has been characterized by low-field Overhauser dynamic nuclear polarization (ODNP) relaxometry using a series of spin-labeled constructs. Sites for spin-label incorporation were previously designed via an atomistic computational approach that screened for surface exposure, reflective of the surface hydration comparable to other proteins studied by this method, as well as minimal impact on protein function, dynamics, and structure of BSLA by… Show more

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