Hydrostatic pressure promotes migration and filamin-A activation in fibroblasts with increased p38 phosphorylation and TGF-β production

Kao, Yu-Chiu; Chen, Zih-Hua; Wang, Wenyu; Lee, Chau‐Hwang; Kuo, P. C.

doi:10.1016/j.bbrc.2021.06.055

Cited by 2 publications

(3 citation statements)

References 37 publications

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“…30 Similarly, the motility and proliferation of fibroblast are promoted by increased HP-induced p38 MAPK cascades. 31,32 Fluid shear stress The intra-organ or intra-capsule fluid can both generate FSS by the fluid flow. Typical FSS exists in human vasculature (i.e., vessel bifurcations, stenosis, aortic aneurysms, heart valves, and capillary networks), including shear and extensional flow.…”

Section: Characteristics and Mechanisms Of Cellular Mechanotransductionmentioning

confidence: 99%

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Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets

Gao

et al. 2023

Sig Transduct Target Ther

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Cellular mechanotransduction, a critical regulator of numerous biological processes, is the conversion from mechanical signals to biochemical signals regarding cell activities and metabolism. Typical mechanical cues in organisms include hydrostatic pressure, fluid shear stress, tensile force, extracellular matrix stiffness or tissue elasticity, and extracellular fluid viscosity. Mechanotransduction has been expected to trigger multiple biological processes, such as embryonic development, tissue repair and regeneration. However, prolonged excessive mechanical stimulation can result in pathological processes, such as multi-organ fibrosis, tumorigenesis, and cancer immunotherapy resistance. Although the associations between mechanical cues and normal tissue homeostasis or diseases have been identified, the regulatory mechanisms among different mechanical cues are not yet comprehensively illustrated, and no effective therapies are currently available targeting mechanical cue-related signaling. This review systematically summarizes the characteristics and regulatory mechanisms of typical mechanical cues in normal conditions and diseases with the updated evidence. The key effectors responding to mechanical stimulations are listed, such as Piezo channels, integrins, Yes-associated protein (YAP) /transcriptional coactivator with PDZ-binding motif (TAZ), and transient receptor potential vanilloid 4 (TRPV4). We also reviewed the key signaling pathways, therapeutic targets and cutting-edge clinical applications of diseases related to mechanical cues.

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Section: Characteristics and Mechanisms Of Cellular Mechanotransductionmentioning

confidence: 99%

“… 30 Similarly, the motility and proliferation of fibroblast are promoted by increased HP-induced p38 MAPK cascades. 31 , 32 …”

Section: Characteristics and Mechanisms Of Cellular Mechanotransductionmentioning

confidence: 99%

Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets

Gao

et al. 2023

Sig Transduct Target Ther

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show abstract

“…It has been reported that HP impacts important biological functions, such as cell death (both apoptosis and necrosis), proliferation, migration, and differentiation in several cell types, engaging a variety of mechanotransduction mechanisms [99][100][101][102]. Many lines of evidence show that HP mediates the mobility of Ca 2+ ions, which in turn play an important role in critical cellular functions, such as the commitment of mesenchymal stem cells (MSC) towards a chondrogenic phenotype [103], the lumen formation in blood vessels [104], and the synaptic plasticity regulated by astrocyte cells [105,106].…”

Section: Mechanobiology Of Hydrostatic Pressurementioning

confidence: 99%

Control of hydrostatic pressure and osmotic stress in 3D cell culture for mechanobiological studies

Kourouklis

Wahlsten

Stracuzzi

et al. 2023

Biomaterials Advances

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Hydrostatic pressure promotes migration and filamin-A activation in fibroblasts with increased p38 phosphorylation and TGF-β production

Cited by 2 publications

References 37 publications

Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets

Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets

Control of hydrostatic pressure and osmotic stress in 3D cell culture for mechanobiological studies

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