Hydroxyapatite: A journey from biomaterials to advanced functional materials

Mondal, Sudip; Park, Sumin; Choi, Jaeyeop; Vu, Thi Thu Ha; Doan, Vu Hoang Minh; Vo, Truong Tien; Lee, Byeongil; Oh, Junghwan

doi:10.1016/j.cis.2023.103013

Cited by 44 publications

(10 citation statements)

References 217 publications

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“…Biomineralization and calcium phosphate deposition also can be affected by surface chemistry [211]. Functional groups on scaffold surfaces can affect the formation of HAp crystals [212]. Surface chemistry additionally affects the interactions between the scaffold and host tissue after implantation.…”

Section: Surface Chemistry and Compositionmentioning

confidence: 99%

Recent trends in bone tissue engineering: a review of materials, methods, and structures

Moghaddam,

Bahrami,

Mirzadeh

et al. 2024

Biomed. Mater.

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Bone tissue engineering provides the treatment possibility for segmental long bone defects that are currently an orthopedic dilemma. This review explains different strategies, from biological, material, and preparation points of view, such as using different stem cells, ceramics, and metals, and their corresponding properties for bone tissue engineering applications. In addition, factors such as porosity, surface chemistry, hydrophilicity and degradation behavior that affect scaffold success are introduced. Besides, the most widely used production methods that result in porous materials are discussed. Gene delivery and secretome-based therapies are also introduced as a new generation of therapies. This review outlines the positive results and important limitations remaining in the clinical application of novel bone tissue engineering materials and methods for segmental defects.

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Section: Surface Chemistry and Compositionmentioning

confidence: 99%

Recent trends in bone tissue engineering: a review of materials, methods, and structures

Moghaddam,

Bahrami,

Mirzadeh

et al. 2024

Biomed. Mater.

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“…Hydroxyapatite, with the chemical formula

, is a basic component of the structure of human bones [ 160 , 161 , 162 ]. Apatite also occurs in nature [ 163 , 164 , 165 ], sometimes as inclusions in gems [ 166 ] or in association with other minerals [ 167 , 168 ].…”

Section: Biomaterials Compatible With Antibiotic Infusionmentioning

confidence: 99%

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Periferakis,

Troumpata

et al. 2024

Biomimetics

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The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one of the major complications of such medical interventions. The emergence of novel technologies, especially 3D printing, represents a promising avenue of development for reducing the risk of such eventualities. There are already a host of biomaterials, suitable for 3D printing, that are being tested for antimicrobial properties when they are coated with bioactive compounds, such as antibiotics, or combined with hydrogels with antimicrobial and antioxidant properties, such as chitosan and metal nanoparticles, among others. The materials discussed in the context of this paper comprise beta-tricalcium phosphate (β-TCP), biphasic calcium phosphate (BCP), hydroxyapatite, lithium disilicate glass, polyetheretherketone (PEEK), poly(propylene fumarate) (PPF), poly(trimethylene carbonate) (PTMC), and zirconia. While the recent research results are promising, further development is required to address the increasing antibiotic resistance exhibited by several common pathogens, the potential for fungal infections, and the potential toxicity of some metal nanoparticles. Other solutions, like the incorporation of phytochemicals, should also be explored. Incorporating artificial intelligence (AI) in the development of certain orthopedic implants and the potential use of AI against bacterial infections might represent viable solutions to these problems. Finally, there are some legal considerations associated with the use of biomaterials and the widespread use of 3D printing, which must be taken into account.

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“…Osseointegration occurs when an implant fuses with surrounding bones due to mechanical properties. To improve long-term effectiveness and aesthetic outcomes, new implant designs, surface modifications, and implant-abutment connections are being investigated [ 24 , 58 – 60 ]. Porous HA can be manufactured through ceramic slip foaming, replicated reticulated foam scaffolds, destruction of sacrificial porogens like polymer beads, or hydrothermal conversion of calcium-based coral or bone.…”

Section: Biomaterials In Drug Delivery Of Dental Implantmentioning

confidence: 99%

“…These implants repair cartilage, regenerate bone and manufacture tissues. Integrating HA with 3D printing and additive manufacturing has led to a new era of personalized implants [ 24 , 63 , 66 , 67 ].…”

Section: Biomaterials In Drug Delivery Of Dental Implantmentioning

confidence: 99%

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The current applications of nano and biomaterials in drug delivery of dental implant

Hakim,

Yari,

Nikparto

et al. 2024

BMC Oral Health

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Background and aim Dental implantology has revolutionized oral rehabilitation, offering a sophisticated solution for restoring missing teeth. Despite advancements, issues like infection, inflammation, and osseointegration persist. Nano and biomaterials, with their unique properties, present promising opportunities for enhancing dental implant therapies by improving drug delivery systems. This review discussed the current applications of nano and biomaterials in drug delivery for dental implants. Method A literature review examined recent studies and advancements in nano and biomaterials for drug delivery in dental implantology. Various materials, including nanoparticles, biocompatible polymers, and bioactive coatings, were reviewed for their efficacy in controlled drug release, antimicrobial properties, and promotion of osseointegration. Results Nano and biomaterials exhibit considerable potential in improving drug delivery for dental implants. Nanostructured drug carriers demonstrate enhanced therapeutic efficacy, sustained release profiles, and improved biocompatibility. Furthermore, bioactive coatings contribute to better osseointegration and reduced risks of infections. Conclusion Integrating current nano and biomaterials in drug delivery for dental implants holds promise for advancing clinical outcomes. Enhanced drug delivery systems can mitigate complications associated with dental implant procedures, offering improved infection control, reduced inflammation, and optimized osseointegration.

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Hydroxyapatite: A journey from biomaterials to advanced functional materials

Cited by 44 publications

References 217 publications

Recent trends in bone tissue engineering: a review of materials, methods, and structures

Recent trends in bone tissue engineering: a review of materials, methods, and structures

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

The current applications of nano and biomaterials in drug delivery of dental implant

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