Hydroxyapatite agarose composite gels as a biochemical material for the repair of alveolar bone defects due to cleft lip and palate

Iwai, Shinichi; Shimizu, Hidetaka; Suzawa, Yoshika; Akashi, Mitsuru; Yura, Yoshiaki

doi:10.1016/j.ajoms.2015.01.003

Cited by 16 publications

(18 citation statements)

References 14 publications

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“…The composite was mixed with autologous bone and implanted to alveolar bone defects. Bone density increased, and neither infections nor increased inflammation were observed at the transplant site within one month [ 169 ]. Kolanthai and colleagues used a sol–gel technique of hydroxyapatite precipitation in agarose solution before gelling.…”

Section: Strategies In Scaffold Manufacturingmentioning

confidence: 99%

Small Molecules Enhance Scaffold-Based Bone Grafts via Purinergic Receptor Signaling in Stem Cells

Ottensmeyer

Witzler

Schulze

et al. 2018

IJMS

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The need for bone grafts is high, due to age-related diseases, such as tumor resections, but also accidents, risky sports, and military conflicts. The gold standard for bone grafting is the use of autografts from the iliac crest, but the limited amount of accessible material demands new sources of bone replacement. The use of mesenchymal stem cells or their descendant cells, namely osteoblast, the bone-building cells and endothelial cells for angiogenesis, combined with artificial scaffolds, is a new approach. Mesenchymal stem cells (MSCs) can be obtained from the patient themselves, or from donors, as they barely cause an immune response in the recipient. However, MSCs never fully differentiate in vitro which might lead to unwanted effects in vivo. Interestingly, purinergic receptors can positively influence the differentiation of both osteoblasts and endothelial cells, using specific artificial ligands. An overview is given on purinergic receptor signaling in the most-needed cell types involved in bone metabolism—namely osteoblasts, osteoclasts, and endothelial cells. Furthermore, different types of scaffolds and their production methods will be elucidated. Finally, recent patents on scaffold materials, as wells as purinergic receptor-influencing molecules which might impact bone grafting, are discussed.

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Section: Strategies In Scaffold Manufacturingmentioning

confidence: 99%

Small Molecules Enhance Scaffold-Based Bone Grafts via Purinergic Receptor Signaling in Stem Cells

Ottensmeyer

Witzler

Schulze

et al. 2018

IJMS

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“…The use of HA/Col, HAp gel, or DBB in combination with iliac crest bone grafting reduces the volume of the autologous bone graft required ( Takemaru et al., 2016 ; Iwai et al., 2015 ; Thuaksuban et al., 2010 ); this suggests that such methods could have favorable results in the treatment of alveolar bone clefts, as they reduce the morbidity of the donor site ( Iwai et al., 2015 ).…”

Section: Discussionmentioning

confidence: 99%

“… 12 12 RCT Platelet-rich fibrin with iliac bone Iliac bone 6 months postoperatively CT scans after 6 months Platelet-rich fibrin in combination with autogenous bone improves the volume, but does not enhance the bone density. 1- Low risk Iwai et al. (2015) 10 10 PCT Mixture of HAp gel and iliac bone 9: Iliac bone 1: Autologous jawbone 1, 3, and 6 months postoperatively Oclussal radiography after 1, 3 and 6 months HAp gel with autologous bone is as effective as autologous bone alone and can reduce the volume of the autologous bone required.…”

Section: Methodological Quality Of the Included Studiesmentioning

confidence: 99%

“…Ten studies conducted on autologous bone grafts from the iliac crest combined with different biomaterials were found. These materials were as follows: HA ( Takemaru et al., 2016 ; Iwai et al., 2015 ), acellular dermal matrix film ( Xiao et al., 2016 ), platelet-rich plasma (PRP) ( Shawky and Seifeldin, 2016 ; Hegab and Shuman, 2012 ; Marukawa et al., 2011 ; Luaces-Rey et al., 2010 ; Lee et al., 2009 ), deproteinized bovine bone (DBB) ( Thuaksuban et al., 2010 ), and fibrin glue ( Segura-Castillo et al., 2005 ). The control group in these studies was treated with bone grafts from the iliac crest or mandibular bone.…”

Section: Methodological Quality Of the Included Studiesmentioning

confidence: 99%

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Evaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: A systematic review

Osorio

Escobar

González

et al. 2020

Heliyon

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Objective To assess clinical studies that compare synthetic or enriched natural materials to autologous osseous grafts among individuals with cleft lip and palate to determine which would be the substitute to autologous bone graft for alveolar cleft repair in humans. Materials and methods Randomized and controlled clinical trials on alveolar clefts treated with synthetic bone substitutes and autogenous bone grafts combined with osteoinductive factors compared with autogenous bone grafts alone (with ≥4-month follow-up and reporting clinical/radiographic data) were considered eligible. MEDLINE, EMBASE, and Central databases were searched for articles published until February 2020. Results Of 73 eligible articles, 15 were included. Some inductive factors along with iliac crest bone decreased bone reabsorption, preserved the generated bone height/width, and reduced the required autologous bone graft volume. Bone morphogenetic protein (BMP2) as an autologous bone graft substitute, demonstrated satisfactory alveolar defect healing, by avoiding autograft use. Many materials did not yield better outcomes than did autologous grafts; however, hydroxyapatite and collagen complex, hydroxyapatite agarose composite gel, acellular dermal matrix film, fibrin glue, platelet-rich plasma, and deproteinized bovine bone showed similar bone healing outcomes, being an alternative alveolar defect treatment. Conclusions BMP2, as an osteoinductive factor along with a synthetic matrix, yields satisfactory bone healing and avoids the need for autologous bone grafts. However, high-quality RCTs are necessary to determine the most effective and safe concentration and protocol of BMP2 utilization as a substitute for the autologous iliac crest bone grafting.

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“…The development of new composite hydrogels to repair the alveolar bone defects offers faster absorption and rapidly replaced by a new bone, compared with the conventional bone grafting materials like hydroxyapatite ceramics [12]. Similarly, herein we report the hydroxyapatite-calcium sulfate-hyaluronic acid (HAP/CS/HA) encapsulated collagenase as a novel bone grafting implant for the periodontitis therapy, which could promote the restoration of alveolar bone formation without the expense of additional growth factors or cell sources.…”

Section: Introductionmentioning

confidence: 91%

Hydroxyapatite-calcium sulfate-hyaluronic acid composite encapsulated with collagenase as bone substitute for alveolar bone regeneration

Sadhasivam

Fang

Savitha³

et al. 2016

Biomaterials

116

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Hydroxyapatite agarose composite gels as a biochemical material for the repair of alveolar bone defects due to cleft lip and palate

Cited by 16 publications

References 14 publications

Small Molecules Enhance Scaffold-Based Bone Grafts via Purinergic Receptor Signaling in Stem Cells

Small Molecules Enhance Scaffold-Based Bone Grafts via Purinergic Receptor Signaling in Stem Cells

Evaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: A systematic review

Hydroxyapatite-calcium sulfate-hyaluronic acid composite encapsulated with collagenase as bone substitute for alveolar bone regeneration

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