Hydroxyapatite coating converts fibrous tissue to bone around loaded implants

Søballé, Kjeld; Es, Hansen; Brockstedt-Rasmussen, H; Bünger, Cody

doi:10.1302/0301-620x.75b2.8444949

Cited by 395 publications

(217 citation statements)

References 25 publications

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“…Recent studies have suggested that a circumferentially porous-coated, osseointegrated implant, or one that is coated with hydroxyapatite, may function in the same way as a well-fixed cemented implant. 58,59 There were some limitations to our study. We assigned an implant to a particular group according to established clinical and radiological criteria, but no special radiographic views were used.…”

Section: Discussionmentioning

confidence: 93%

Cellular profile and cytokine production at prosthetic interfaces

Goodman¹,

Huie

Song³

et al. 1998

The Journal of Bone and Joint Surgery. British volume

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T he tissues surrounding 65 cemented and 36 cementless total joint replacements undergoing revision were characterised for cell types by immunohistochemistry and for cytokine expression by in situ hybridisation.We identified three distinct groups of revised implants: loose implants with ballooning radiological osteolysis, loose implants without osteolysis, and well-fixed implants. In the cemented series, osteolysis was associated with increased numbers of macrophages (

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Section: Discussionmentioning

confidence: 93%

Cellular profile and cytokine production at prosthetic interfaces

Goodman¹,

Huie

Song³

et al. 1998

The Journal of Bone and Joint Surgery. British volume

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“…Since then numerous reports have been published about the osteoconductive properties of CaP-coated implants (osteoconduction refers to the ability of a biomaterial to support the growth of bone over its surface). These CaP coatings are described to induce an increased bone-to-implant contact (38,(43)(44)(45), to improve the implant fixation (46), and to facilitate the bridging of small gaps between implant and surrounding bone (47,48). As an example of the osteoconductive properties of CaP coatings, Fig.…”

Section: Calcium Phosphate Coatingsmentioning

confidence: 99%

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

et al. 2008

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Abstract. This paper reviews current physicochemical and biochemical coating techniques that are investigated to enhance bone regeneration at the interface of titanium implant materials. By applying coatings onto titanium surfaces that mimic the organic and inorganic components of living bone tissue, a physiological transition between the non-physiological titanium surface and surrounding bone tissue can be established. In this way, the coated titanium implants stimulate bone formation from the implant surface, thereby enhancing early and strong fixation of bone-substituting implants. As such, a continuous transition from bone tissue to implant surface is induced. This review presents an overview of various techniques that can be used to this end, and that are inspired by either inorganic (calcium phosphate) or organic (extracellular matrix components, growth factors, enzymes, etc.) components of natural bone tissue. The combination, however, of both organic and inorganic constituents is expected to result into truly bone-resembling coatings, and as such to a new generation of surface-modified titanium implants with improved functionality and biological efficacy.

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“…Hydroxyapatite coating (HA) is one such surface modification that has been suggested as a method to improve the bone-implant interface and perhaps also increase the strength of the surrounding bone. Loading might alter the fixation strength gained by HA coating, as the material is osteoconductive and has the capacity to replace fibrous membrane with bone around loaded implants [28]. Plasma-sprayed HA coatings have been shown to be effective for enhancement of the holding strength of external fixation pins when used for stabilisation of tibial fractures [19].…”

Section: Bengt Sandén Claes Olerud Sune Larssonmentioning

confidence: 99%