Hydroxyapatite composited PEEK with 3D porous surface enhances osteoblast differentiation through mediating NO by macrophage

Liu, Xingdan; Ouyang, Liping; Chen, Lan; Qiao, Yan; Ma, Xiaohan; Xu, Guohua; Liu, Xuanyong

doi:10.1093/rb/rbab076

Cited by 25 publications

(12 citation statements)

References 56 publications

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“…However, the mechanical strength of the HA/PEEK composite materials became inferior, which is consistent with previous studies. 29 The poor mechanical strength may be attributed to the surface microstructure and internal architectural issues. 23,24,30,31 Addressing this limitation is essential to expand the range of medical applications of these materials in clinical settings.…”

Section: Discussionmentioning

confidence: 99%

PUD@HA/PEEK Scaffold Induces Subchondral Bone Regeneration to Repair Osteochondral Defect in Rabbits

Li,

Teng,

Mao

et al. 2024

ACS Biomater. Sci. Eng.

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Osteochondral defects (OCDs) pose a significant challenge in clinical practice, and recent advancements in their repair indicate that satisfying subchondral bone repair may be critical for this. Herein, a series of hydroxyapatite/poly(ether ether ketone) (HA/PEEK) scaffolds were fabricated with varying mass percentages (0, 20, 30, and 40%) to induce subchondral bone regeneration. Subsequently, an optimal scaffold with 40% HA/PEEK was selected to establish osteochondral scaffolds with poly(ether urethane) urea-Danshensu (PUD) for repairing the OCD. The material characteristics of HA/PEEK and PUD were investigated using scanning electron microscopy, tensile, swelling, and fatigue tests, and cytological experiments. The effects of serial HA/PEEK scaffolds on subchondral bone repair were then assessed by using microcomputed tomography, hard tissue slicing, and histological staining. Furthermore, the optimal 40% HA/PEEK scaffold was used to develop osteochondral scaffolds with PUD to observe the effect on the OCD repair. HA/PEEK materials exhibited an even HA distribution in PEEK. However, when composited with HA, PEEK exhibited inferior mechanical strength. 40%HA/PEEK scaffolds showed an optimum effect on in vivo subchondral bone repair. Cartilage regeneration on 40%HA/PEEK scaffolds was pronounced. After PUD was introduced onto the HA/PEEK, the PUD@40%HA/PEEK scaffold produced the expected effect on the repair of the OCD in rabbits. Therefore, achieving satisfactory subchondral bone repair can benefit surficial cartilage repair. The PUD@40%HA/PEEK scaffold could induce subchondral bone regeneration to repair the OCD in rabbits and could provide a novel approach for the repair of the OCD in clinical practice.

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Section: Discussionmentioning

confidence: 99%

PUD@HA/PEEK Scaffold Induces Subchondral Bone Regeneration to Repair Osteochondral Defect in Rabbits

Li,

Teng,

Mao

et al. 2024

ACS Biomater. Sci. Eng.

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“…The authors cleared that hydrogel functional groups facilitate apatite formation in the extracellular matrix 60 . Liu et al indicated osteoblastic differentiation capacity of bone marrow mesenchymal stem cells in 3D constructions of PEEK 66 . Some studies suggested the increased osteogenic capacity of PEEK while incorporated or modified by different substances 19,22,24,48 .…”

Section: Discussionmentioning

confidence: 99%

A novel injectable hydrogel containing polyetheretherketone for bone regeneration in the craniofacial region

Alipour

Ghorbani

khatoonabad

et al. 2023

Sci Rep

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Polyetheretherketone (PEEK) is an organic material introduced as an alternative for titanium implants. Injectable hydrogels are the most promising approach for bone regeneration in the oral cavity to fill the defects with irregular shapes and contours conservatively. In the current study, injectable Aldehyde-cellulose nanocrystalline/silk fibroin (ADCNCs/SF) hydrogels containing PEEK were synthesized, and their bone regeneration capacity was evaluated. Structure, intermolecular interaction, and the reaction between the components were assessed in hydrogel structure. The cytocompatibility of the fabricated scaffolds was evaluated on human dental pulp stem cells (hDPSCs). Moreover, the osteoinduction capacity of ADCNCs/SF/PEEK hydrogels on hDPSCs was evaluated using Real-time PCR, Western blot, Alizarin red staining and ALP activity. Bone formation in critical-size defects in rats’ cranial was assessed histologically and radiographically. The results confirmed the successful fabrication of the hydrogel and its osteogenic induction ability on hDPSCs. Furthermore, in in vivo phase, bone formation was significantly higher in ADCNCs/SF/PEEK group. Hence, the enhanced bone regeneration in response to PEEK-loaded hydrogels suggested its potential for regenerating bone loss in the craniofacial region, explicitly surrounding the dental implants.

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“…(b) Expression of osteogenic-related genes. (c) Interaction of materials, macrophages, and mBMSCs ( Liu et al, 2022 ). (C) Under the presence of bacteria, the production of ROS increases SB content and macrophage activity.…”

Section: Modification For Enhanced Biopropertiesmentioning

confidence: 99%

State-of-the-art polyetheretherketone three-dimensional printing and multifunctional modification for dental implants

Chen,

Ren,

Shi

et al. 2023

Front. Bioeng. Biotechnol.

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Polyetheretherketone (PEEK) is a high-performance thermoplastic polymer with an elastic modulus close to that of the jawbone. PEEK has the potential to become a new dental implant material for special patients due to its radiolucency, chemical stability, color similarity to teeth, and low allergy rate. However, the aromatic main chain and lack of surface charge and chemical functional groups make PEEK hydrophobic and biologically inert, which hinders subsequent protein adsorption and osteoblast adhesion and differentiation. This will be detrimental to the deposition and mineralization of apatite on the surface of PEEK and limit its clinical application. Researchers have explored different modification methods to effectively improve the biomechanical, antibacterial, immunomodulatory, angiogenic, antioxidative, osteogenic and anti-osteoclastogenic, and soft tissue adhesion properties. This review comprehensively summarizes the latest research progress in material property advantages, three-dimensional printing synthesis, and functional modification of PEEK in the fields of implant dentistry and provides solutions for existing difficulties. We confirm the broad prospects of PEEK as a dental implant material to promote the clinical conversion of PEEK-based dental implants.

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Hydroxyapatite composited PEEK with 3D porous surface enhances osteoblast differentiation through mediating NO by macrophage

Cited by 25 publications

References 56 publications

PUD@HA/PEEK Scaffold Induces Subchondral Bone Regeneration to Repair Osteochondral Defect in Rabbits

PUD@HA/PEEK Scaffold Induces Subchondral Bone Regeneration to Repair Osteochondral Defect in Rabbits

A novel injectable hydrogel containing polyetheretherketone for bone regeneration in the craniofacial region

State-of-the-art polyetheretherketone three-dimensional printing and multifunctional modification for dental implants

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