Hydroxyapatite Crystal Formation in the Presence of Polysaccharide

Fang, Wancai; Zhang, Hong; Yin, Jianwei; Yang, Boguang; Zhang, Yabin; Li, Junjie; Yao, Fanglian

doi:10.1021/acs.cgd.5b01235

Cited by 76 publications

(81 citation statements)

References 46 publications

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“…On the other hand, the non-stoichiometric HAp structures were analysed in both films prepared with lower content of CNF (0.5CNF): A phosphorus-rich (calcium-deficient) HAp with Ca/P ration of 1.56 on the CNF prepared with 100HAp was in agreement with reported literature (Fang et al 2016), and a calcium-rich (phosphorus-deficient) with Ca/P of 1.77 on the film prepared with 25HAp.…”

Section: Films' Characterizationsupporting

confidence: 85%

In-situ synthesised hydroxyapatite-loaded films based on cellulose nanofibrils for phenol removal from wastewater

2017

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Phenol removal from aqueous medium was studied by the batch method using novel and fully biobased solvent-cast films prepared from cellulose nanofibrils (CNFs) and in situ synthesised hydroxyapatite (HAp) by the wet-chemical precipitation method and different concentrations of HAp precursors and weight mass of CNFs. The chemical and morphological structures of as-prepared films were investigated by X-ray diffraction, scanning electron microscopy, and energy-dispersive spectroscopy, while their physical properties were determined by water contact angle and swelling kinetic measurements. The HAp precursor leads to a surface modification of CNFs, which increases its activity by forming differently structured, sized and distributed HAp particles, influencing the phenol adsorption kinetic and capacity. The phenol adsorption was faster and higher (*64 mg g -1 ) in an acidic solution (pH 2) compared to the original phenol solution pH (pH 7.4, *30 mg g -1 ) using films with unevenly-distributed and positively-charged calcium-richer HAp particles synthesised on the CNFs' surface, being reflected also in its higher water swelling properties, compared to their hybrid counterparts. The phenol adsorption is identified to follow pseudo-second order kinetic and intra-particle diffusion models. A highly-efficient reusing ability of the selected film with 86% adsorption capacity of the initial value at the third sequential regeneration cycle, is also confirmed. A super-hydrophilic nature of the films with high water-diffusing and transport properties, as well as low swelling, indicates their potential in the development of highlyeffective adsorbents and, potentially, filter membranes for water purification.

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Section: Films' Characterizationsupporting

confidence: 85%

In-situ synthesised hydroxyapatite-loaded films based on cellulose nanofibrils for phenol removal from wastewater

2017

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“…However, carrageenan offers advantages over cellulose: unlike cellulose, the former biopolymer is highly soluble in water and dismisses the need for chemical and/or physical modification to its structure to obtain homogeneous hydrogels. Furthermore, the presence of sulfate groups in carrageenan provides it with the potential to mimic the negatively charged macromolecules, like glycosaminoglycans (GAGs), present in the bone extracellular matrix . In addition, regarding hybrid material formation, Zhu et al .…”

Section: Introductionmentioning

confidence: 99%

“…We seek to evaluate how the organic matrix influences mineral phase formation by changing the HC and ι‐Carr ratio used to prepare the membrane. The negatively charged −OSO 3 − groups in the ι‐Carr structure serve as binding sites for Ca 2+ ions and engage in hydrogen bonding with PO 4 3− and H 2 O on the mineral surface, which is suitable for in situ biomineral heterogeneous nucleation. Indeed, the literature highlights that the presence of many nucleation sites, including −OSO 3 Ca + and (−OSO 3 ) 2 Ca, in the matrix consisting of ι‐Carr favors crystal growth .…”

Section: Introductionmentioning

confidence: 99%

Organic–inorganic collagen/iota‐carrageenan/hydroxyapatite hybrid membranes are bioactive materials for bone regeneration

Nogueira

Maniglia

Blácido

et al. 2019

J of Applied Polymer Sci

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This study aimed to produce biomembranes with controlled degradability for application in bone regeneration in order to stimulate biological reactions necessary to improve bone formation. Hydrogels were prepared by dissolving hydrolyzed collagen (HC) and iota‐carrageenan (ι‐Carr) in aqueous mixtures containing CaCl2 and H3PO4. A rise in pH by exposure to NH3(g) caused mineral precipitation into the hydrogel. Subsequently, the membranes were fabricated by solvent casting. Infrared spectroscopy and X‐ray diffraction attested hydroxyapatite formation. The crystallite size was close to 12 nm, which was smaller than the size reported for human bone apatite. The membranes induced bone‐like apatite precipitation in simulated body fluid. The carrageenan content modulated the membrane mechanical behavior. Membranes with controlled degradability were obtained by using higher amount of this polysaccharide. These membranes were able to release HC in physiological conditions. The surface properties were evaluated in terms of wettability and surface energy (γS) by means of contact angle (θc) measurements. Low θc (8.5–16.8) indicated that the hybrid membranes were hydrophilic, while higher γS values, around 70.6 mJ.m−2, could favor biomolecule incorporation into the surface. Our data set evidenced that these materials could potentially be used as a temporary guided tissue regeneration membrane with the possibility of inducing bone regeneration. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48004.

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“…Furthermore, the band at 1598 cm -1 in CS was related to N-H amide I [21] and this band in CS was shifted to lower wave number in all nanocomposites as shown in Fig.1 (B, C, D and E) due to the interaction of CS with HA [22]. This shift was previously attributed to the binding of chemical function groups of CS (−NH 2 and −NHCO−) and PO 4 3− via electrostatic interaction or Ca 2+ via coordination bond [23]. Finally in the case of acrylic acid, the band at 1598 cm -1 suffered smaller shift which indicated that the in situ formed HA did not have strong interaction with CS's amino groups.…”

Section: Resultsmentioning

confidence: 56%

The Effect of Different Solvents for Chitosan Solubilization on The Crystal Growth of in situ Prepared Hydroxyapatite

2017

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C HITOSAN/hydroxyapatite (CS/HA) nanocomposites have been widely fabricated for potential use in bone defects due to their high biocompatibility and similarity to the natural bone. In the current study, HA nanocrystals were prepared by co-precipitation method in CS which was initially dissolved in different concentrations of acrylic acid and acetic acid (2 and 4 %). The effect of chitosan solvents on the morphology of HA nanocrystals, the crystallite sizes, and the physical binding with CS were investigated by different techniques including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and transmission electron microscope (TEM). The FT-IR and XPS results showed that the interaction between CS and HA in the nanocomposites is predominantly dependent on the type of solvent used to dissolve CS. When acetic acid was used, the interaction between CS and HA was stronger when compared to acrylic acid. Quantitative XPS results showed that the atomic percentage of nitrogen (N1s) of the amine groups of CS was less in the case of the composites prepared after dissolving CS in acrylic acid compared to acetic acid. The amine groups of CS (−NH 2 ) can start the nucleation of HA crystals and remain bounded to the surface of the grown crystal through chelation with calcium ions on the crystal facets. In both organic solvents, HA crystals were found to grow along their c-axis direction into rodshape but the growth in the width was more restricted in case of acetic acid. The results in the current study indicated that the type of CS solvents is determining the strength of the physical interaction between the CS and HA. This might be a crucial factor to control and enhance the mechanical and the biological behaviors of the nanocomposites.

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Hydroxyapatite Crystal Formation in the Presence of Polysaccharide

Cited by 76 publications

References 46 publications

In-situ synthesised hydroxyapatite-loaded films based on cellulose nanofibrils for phenol removal from wastewater

In-situ synthesised hydroxyapatite-loaded films based on cellulose nanofibrils for phenol removal from wastewater

Organic–inorganic collagen/iota‐carrageenan/hydroxyapatite hybrid membranes are bioactive materials for bone regeneration

The Effect of Different Solvents for Chitosan Solubilization on The Crystal Growth of in situ Prepared Hydroxyapatite

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