Hydroxyapatite granules interposed at bone-cement interface in total hip replacements: Histological study of retrieved specimens

Oonishi, Hironobu; Kadoya, Y.; Iwaki, Hiroaki; Kin, N.

doi:10.1002/(sici)1097-4636(2000)53:2<174::aid-jbm7>3.0.co;2-o

Cited by 37 publications

(15 citation statements)

References 13 publications

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“…3,17 Retrieval studies showed that the majority of the HA granules were incorporated into remodelled trabeculae at a maximum follow-up of ten years. 18 These promising results are in contrast to the present, and other experimental studies. 14,15 This may be a function of difference in duration of implantation before analysis was undertaken, with Oonishi et al 18 making observations at up to ten years and our own being made after only three weeks.…”

Section: Discussioncontrasting

confidence: 94%

Osteogenic protein-1 increases the fixation of implants grafted with morcellised bone allograft and ProOsteon bone substitute

Jensen

Overgaard

Lind

et al. 2007

The Journal of Bone and Joint Surgery. British volume

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Impacted bone allograft is often used in revision joint replacement. Hydroxyapatite granules have been suggested as a substitute or to enhance morcellised bone allograft. We hypothesised that adding osteogenic protein-1 to a composite of bone allograft and non-resorbable hydroxyapatite granules (ProOsteon) would improve the incorporation of bone and implant fixation. We also compared the response to using ProOsteon alone against bone allograft used in isolation. We implanted two non-weight-bearing hydroxyapatite-coated implants into each proximal humerus of six dogs, with each implant surrounded by a concentric 3 mm gap. These gaps were randomly allocated to four different procedures in each dog: 1) bone allograft used on its own; 2) ProOsteon used on its own; 3) allograft and ProOsteon used together; or 4) allograft and ProOsteon with the addition of osteogenic protein-1. After three weeks osteogenic protein-1 increased bone formation and the energy absorption of implants grafted with allograft and ProOsteon. A composite of allograft, ProOsteon and osteogenic protein-1 was comparable, but not superior to, allograft used on its own. ProOsteon alone cannot be recommended as a substitute for allograft around non-cemented implants, but should be used to extend the volume of the graft, preferably with the addition of a growth factor.

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Section: Discussioncontrasting

confidence: 94%

Osteogenic protein-1 increases the fixation of implants grafted with morcellised bone allograft and ProOsteon bone substitute

Jensen

Overgaard

Lind

et al. 2007

The Journal of Bone and Joint Surgery. British volume

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“…Our results show that unlike granular hydroxyapatites of synthetic or natural origin, which persist in grafted sites for 6 to 9 years or more (14,15,18,19), the active or passive dissolution of aqueous nanocrystalline hydroxyapatite (Ostim ® ) leads in less than 12 months to a skeletal segment that is almost completely composed of bone, the ideal tissue for supporting implants.…”

Section: Discussionmentioning

confidence: 87%

Behavior of aqueous nanocrystalline hydroxyapatite in oral bone regeneration

Zaffe

Traversa²,

Mozzati³

et al. 2011

JABB

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“…Oonishi et al (2000) confirmed that there were histologically negligible foreign body reactions in the specimens retrieved after ten years of service in vivo. They attributed this to the fact that the particle size of HA granules was relatively large (100–300 μm) and that most of the granules were incorporated.…”

Section: Discussionmentioning

confidence: 59%

A modified cementing technique using BoneSource to augment fixation of the acetabulum in a sheep model

Timperley

Nusem

Wilson³

et al. 2010

Acta Orthopaedica

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Background and purposeOur aim was to assess in an animal model whether the use of HA paste at the cement-bone interface in the acetabulum improves fixation. We examined, in sheep, the effect of interposing a layer of hydroxyapatite cement around the periphery of a polyethylene socket prior to fixing it using polymethylmethacrylate (PMMA).MethodsWe performed a randomized study involving 22 sheep that had BoneSource hydroxyapatite material applied to the surface of the acetabulum before cementing a polyethylene cup at arthroplasty. We studied the gross radiographic appearance of the implant-bone interface and the histological appearance at the interface.ResultsThere were more radiolucencies evident in the control group. Histologically, only sheep randomized into the BoneSource group exhibited a fully osseointegrated interface. Use of the hydroxyapatite material did not give any detrimental effects. In some cases, the material appeared to have been fully resorbed. When the material was evident in histological sections, it was incorporated into an osseointegrated interface. There was no giant cell reaction present. There was no evidence of migration of BoneSource to the articulation.InterpretationThe application of HA material prior to cementation of a socket produced an improved interface. The technique may be useful in humans, to extend the longevity of the cemented implant by protecting the socket interface from the effect of hydrodynamic fluid flow and particulate debris.

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Hydroxyapatite granules interposed at bone-cement interface in total hip replacements: Histological study of retrieved specimens

Cited by 37 publications

References 13 publications

Osteogenic protein-1 increases the fixation of implants grafted with morcellised bone allograft and ProOsteon bone substitute

Osteogenic protein-1 increases the fixation of implants grafted with morcellised bone allograft and ProOsteon bone substitute

Behavior of aqueous nanocrystalline hydroxyapatite in oral bone regeneration

A modified cementing technique using BoneSource to augment fixation of the acetabulum in a sheep model

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