2004
DOI: 10.1267/ahc.37.101
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Hydroxyapatite Maturity in the Calcified Cartilage and Underlying Subchondral Bone of Guinea Pigs with Spontaneous Osteoarthritis: Analysis by Fourier Transform Infrared Microspectroscopy

Abstract: The aim of the present study was to investigate the quantity and quality of hydroxyapatite (HA) in the zone of calcified cartilage of articular cartilage and underlying subchondral bone by Fourier transform infrared microscopy (FTIRM). We hypothesized that the amount of HA deposited in osteoarthritis (OA) might differ from normal cartilage, and that such differences might be significant in the pathology of OA. The tibial epiphysis of the male Hartley strain for the spontaneous OA model and the control Strain 1… Show more

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Cited by 9 publications
(11 citation statements)
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“…Not many studies have investigated time-course relationships from before the onset of cartilage degeneration. The Hartley guinea pig spontaneously develops degenerative changes of cartilage that are similar to those of human OA in the knee joint, and it is used as an OA model (1,7,12,20,21,(26)(27)(28)(29)(30)(31)(32). However, unlike surgical OA models using non-surgically treated animals as controls, no control has been available for the Hartley guinea pig model, which is disadvantageous (31).…”
Section: Figure 4 Examples Of 3-dimensional Reconstruction Of Microfmentioning
confidence: 99%
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“…Not many studies have investigated time-course relationships from before the onset of cartilage degeneration. The Hartley guinea pig spontaneously develops degenerative changes of cartilage that are similar to those of human OA in the knee joint, and it is used as an OA model (1,7,12,20,21,(26)(27)(28)(29)(30)(31)(32). However, unlike surgical OA models using non-surgically treated animals as controls, no control has been available for the Hartley guinea pig model, which is disadvantageous (31).…”
Section: Figure 4 Examples Of 3-dimensional Reconstruction Of Microfmentioning
confidence: 99%
“…However, unlike surgical OA models using non-surgically treated animals as controls, no control has been available for the Hartley guinea pig model, which is disadvantageous (31). It has recently been reported that the Weiser-Maple guinea pig (strain 13) is appropriate as a control for the Hartley guinea pig (7,30). In Weiser-Maple guinea pigs (strain 13), knee OA did not develop before age 30 months, and body weight was not significantly different from that of Hartley guinea pigs until the age of 6 months (33).…”
Section: Figure 4 Examples Of 3-dimensional Reconstruction Of Microfmentioning
confidence: 99%
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“…Synchrotron FTIR (sFTIR) has been used to study mineralizing tissues, such as bone, as well as cartilage (19) (20). It has proven useful in the study of various factors influencing matrix mineralization in that it can be used quantitatively to estimate amounts and quality of mineral formed (21) (22).…”
Section: Introductionmentioning
confidence: 99%
“…The Hartley guinea pig spontaneously develops degenerative changes of cartilage that are similar to those of human OA in the knee joint, and it is used as an OA model (1, 7, 12, 20, 21, 26–32). However, unlike surgical OA models using non–surgically treated animals as controls, no control has been available for the Hartley guinea pig model, which is disadvantageous (31).…”
Section: Discussionmentioning
confidence: 99%