Hydroxyapatite Nanoparticle Mesogens: Morphogenesis of pH-Sensitive Macromolecular Liquid Crystals

Benedini, Luciano A.; Moglie, Yanina; Ruso, Juan M.; Nardi, Sofía; Messina, Paula V.

doi:10.1021/acs.cgd.0c01582

Cited by 8 publications

(2 citation statements)

References 64 publications

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“…Solutions in the temperature range of 50–100 ºC can precipitate B-type carbonated HAp [ 65 ]. In this case, a mixture of AB substitution types is formed (A type:

→ OH – ; B type:

→

) [ 66 ] as the synthesis was done at room temperature and the hydrothermal treatment was done at temperatures well over 100 °C. The

ions substitution may have happened because the samples were exposed to ambient CO 2 before to the hydrothermal treatment and, also, the disintegration of CTAB after hydrothermal treatment should be considered as another important factor affecting the process [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Microfluidic Fabrication of Gadolinium-Doped Hydroxyapatite for Theragnostic Applications

et al. 2023

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Among the several possible uses of nanoparticulated systems in biomedicine, their potential as theragnostic agents has received significant interest in recent times. In this work, we have taken advantage of the medical applications of Gadolinium as a contrast agent with the versatility and huge array of possibilities that microfluidics can help to create doped Hydroxyapatite nanoparticles with magnetic properties in an efficient and functional way. First, with the help of Computational Fluid Dynamics (CFD), we performed a complete and precise study of all the elements and phases of our device to guarantee that our microfluidic system worked in the laminar regime and was not affected by the presence of nanoparticles through the flow requisite that is essential to guarantee homogeneous diffusion between the elements or phases in play. Then the obtained biomaterials were physiochemically characterized by means of XRD, FE-SEM, EDX, confocal Raman microscopy, and FT-IR, confirming the successful incorporation of the lanthanide element Gadolinium in part of the Ca (II) binding sites. Finally, the magnetic characterization confirmed the paramagnetic behaviour of the nanoparticles, demonstrating that, with a simple and automatized system, it is possible to obtain advanced nanomaterials that can offer a promising and innovative solution in theragnostic applications.

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“…Solutions in the temperature range of 50–100 ºC can precipitate B-type carbonated HAp [ 65 ]. In this case, a mixture of AB substitution types is formed (A type:

→ OH – ; B type:

→

) [ 66 ] as the synthesis was done at room temperature and the hydrothermal treatment was done at temperatures well over 100 °C. The

Section: Discussionmentioning

confidence: 99%

Microfluidic Fabrication of Gadolinium-Doped Hydroxyapatite for Theragnostic Applications

et al. 2023

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“…For hydroxyapatitebased liquid crystals, stimuli responsive properties and biofunctions, e.g., magnetic eld responsive colloidal liquid crystals composed of nanorods, were reported. 16,18,19 There has been an attractive challenge of capturing the dynamic nature of functional self-organized so materials for designing their material applications. For further functionalization of these colloidal nanorod liquid crystals, it is important to understand the dynamic nature of the materials in their selforganized states.…”

Section: Introductionmentioning

confidence: 99%