Hydroxyapatite Obtained via the Wet Precipitation Method and PVP/PVA Matrix as Components of Polymer-Ceramic Composites for Biomedical Applications

Abstract

The aspect of drug delivery is significant in many biomedical subareas including tissue engineering. Many studies are being performed to develop composites with application potential for bone tissue regeneration which at the same provide adequate conditions for osteointegration and deliver the active substance conducive to the healing process. Hydroxyapatite shows a great potential in this field due to its osteoinductive and osteoconductive properties. In the paper, hydroxyapatite synthesis via the wet precipitation method and its further use as a ceramic phase of polymer–ceramic composites based on PVP/PVA have been presented. Firstly, the sedimentation rate of hydroxyapatite in PVP solutions has been determined, which allowed us to select a 15% PVP solution (sedimentation rate was 0.0292 mm/min) as adequate for preparation of homogenous reaction mixture treated subsequently with UV radiation. Both FT-IR spectroscopy and EDS analysis allowed us to confirm the presence of both polymer and ceramic phase in composites. Materials containing hydroxyapatite showed corrugated and well-developed surface. Composites exhibited swelling properties (hydroxyapatite reduced this property by 25%) in simulated physiological fluids, which make them useful in drug delivery (swelling proceeds parallel to the drug release). The short synthesis time, possibility of preparation of composites with desired shapes and sizes and determined physicochemical properties make the composites very promising for biomedical purposes.

Investigations on the Influence of Collagen Type on Physicochemical Properties of PVP/PVA Composites Enriched with Hydroxyapatite Developed for Biomedical Applications

“…The highest differences were observed during first 24 h of the swelling. Analogous results were presented in other works [ 36 ]. The use of the crosslinking agent PEGDA 575 resulted in the synthesis of polymer matrices consisting of shorter polymer chains compared to the chains occurring in the structure of materials obtained using PEGDA 700.…”

“…PVP/PVA-based composite materials containing HAp were prepared according to procedure described previously in [ 36 ]. Briefly, the aqueous solutions of polymers—PVA and PVP—were mixed with a ceramic phase (HAp) and selected collagen, i.e., fish collagen or bovine collagen.…”

Physicochemical and biological analysis of composite biomaterials containing hydroxyapatite for biological applications

“…Preparation of the ceramic powder was described in our previous article. 23 Briefly, HAp was obtained via the wet precipitation method. As precursors, hydrated calcium nitrate (Ca(NO 3 ) 2 4H 2 O) at a concentration of 0.60 mol/L, and ammonium dihydrogen phosphate (NH 4 H 2 PO 4 ) at a concentration of 0.36 mol/L were applied.…”

Characterization and Antimicrobial Activity of Nigella sativa Extracts Encapsulated in Hydroxyapatite Sodium Silicate Glass Composite

“…Consequently, they are commonly applied in the form of powder, bulk, and coating, for various biomedical applications including bone tissue engineering, maxillofacial, dentistry and as coatings on metallic implants [ 16 , 17 ]. Importantly, nHAp-based materials are highly reactive and interact with biological entities forming chemical bonds with the adjacent biological tissue [ 18 ].…”