Hydroxyapatite Scaffolds Fabrication using Gambas  Sponge ( Luffa cylindrica ) as Novel Template

Fadli, Ahmad; Lubis, Apriadi; Huda, Feblil; Komalasari, Komalasari

doi:10.21063/ictis.2016.1009

Cited by 3 publications

(4 citation statements)

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Section: Resultssupporting

confidence: 75%

“…The synthesised MNPs possess magnetite characteristics (Figure 2), where the blackcoloured sample powder in the sample bottle became attracted upon contact with an external magnetic field. This finding proved the ferromagnetism characteristics of the synthesised black-coloured powder [25,35]. The synthesised MNPs possess magnetite characteristics (Figure 2), where the blackcoloured sample powder in the sample bottle became attracted upon contact with an external magnetic field.…”

Section: Resultssupporting

confidence: 64%

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Molarity Effects of Fe and NaOH on Synthesis and Characterisation of Magnetite (Fe3O4) Nanoparticles for Potential Application in Magnetic Hyperthermia Therapy

et al. 2022

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In this study, the effect of molarity on the structural, magnetic, and heat dissipation properties of magnetite nanoparticles (MNPs) was investigated to optimise the parameters for potential application in magnetic hyperthermia therapy (MHT). MHT works based on the principle of local temperature rise at the tumour site by magnetic iron oxide nanoparticles (MIONPs) with the application of an alternating magnetic field. MHT is a safe method for cancer treatment and has minimal or no side effects. Magnetite (Fe3O4) is the best material among MIONPs to be applied in local MHT due to its biocompatibility and high saturation magnetisation value. MNPs were prepared by co-precipitation at varying molarity. Structural characterisation was performed via X-ray powder diffraction (XRD) for crystalline structure analysis and field-emission scanning electron microscopy (FESEM) for morphology and particle size analysis. Measurement of the magnetic properties of the as-synthesised MNPs was carried out using a vibrating sample magnetometer (VSM). Power loss (P) was determined theoretically. The increase in molarity resulted in significant effects on the structural, magnetic, and heat dissipation properties of MNPs. The particle size and saturation magnetisation (Ms) decreased with the gradual addition of base but increased, together with crystallinity, with the gradual addition of iron source. M3 recorded the smallest crystalline size at 3.559 nm. The sample with the highest molarity (M4) displayed the highest heat generation capacity with a p value of up to 0.4056 W/g. High p values at the nano-scale are crucial, especially in local MHT, for effective heat generation, thus proving the importance of molarity as a vital parameter during MNP synthesis.

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Section: Resultssupporting

confidence: 75%

Section: Resultssupporting

confidence: 64%

Molarity Effects of Fe and NaOH on Synthesis and Characterisation of Magnetite (Fe3O4) Nanoparticles for Potential Application in Magnetic Hyperthermia Therapy

et al. 2022

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“…The results obtained a macro pore of 250-250 µm, 1.1-5.7 MPa compressive strength, 40-70% porosity and 1.80 g/cm 3 density. Additionally, Fadli and Komalasari [11] have been successfully made alumina-hydroxyapatite porous with protein foaming-starch consolidation method. In this method, egg yolk is used as the pore creating agent and starch as the forming agent and ceramic bodies with 44.6-57% porosity as well as 2.6-7.5 MPa compressive strength obtained.…”

Section: Introductionmentioning

confidence: 99%

Response Surface Methodology Study on Macroporous Hydroxyapatite Prepared by Protein Foaming-Consolidation Method

Fadli

Huda

Komalasari

et al. 2020

MSF

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Macroporous hydroxyapatite have been used in biomedical application especially for bone graft. The objective of this research was to study the effect of yolk addition, rate of sintering temperature rise, and rate of stirring on the physical, chemical and mechanical properties of porous hydroxyapatite prepared using protein foaming-starch consolidation method. The slurry was made by mixing the hydroxyapatite and starch powder with Darvan 821A and yolk in a beaker glass. The slurry was stirred mechanically at rate of 150 rpm for 3 hours and it poured in cylindrical mold. Subsequently the slurry was heated in air oven at 180°C for 1 hour. The dried green bodies were burn out at 600°C ended by sintering at 1250°C. The porous hydroxyapatite with average pore size in the range of 13.7-17.9 μm, porosity of 59.3-63.6 % and compressive strength of 5.17-8.2 MPa was obtained. The calculation result of response surface methodology shows that p-value < 0.05 and lack of fit > 0.05. The most effecting factor significantly was hydroxyapatite addition that followed by mixing rate and temperature rising rate of sintering. Optimum condition hydroxyapatite addition of 22 gr, mixing rate of 150 rpm and temperature rising rate of sintering of 2.8°C/minutes with the optimum value of response for pore size by 17.665 μm, porosity by 63.475% and compressive strength 5.17 MPa.

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“…The mostly used of synthetic material on this method is polymeric sponge. Nowadays, the use of polymeric sponge has been improved by using natural template such luffa fibers [12]. This method use bamboo and rattan as template for pore former in different ways.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Porous Hydroxyapatite Bodies Using Bamboo and Rattan Templates

Fadli¹,

Komalasari²,

Huda³

et al. 2019

Proceedings of the International Conference of CELSciTech 2019 - Science and Technology Track (ICCELST-ST 2019)

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Hydroxyapatite (HA) has been widely used as bone graft in form of porous HA/scaffold. This research has a purpose to fabricate HA scaffold by using different biotemplates and determine which biotemplate will give well pore structure on produced HA scaffold. First, HA scaffold obtained used bamboo template. Templates were prepared by cutting bamboo into cylindrical shape and then extracted using ethanol and NaOH solution. Then dipped into mixed of sago starch, NaOH, and distilled water solution / grafting solution. Templates then soaked into CaCl 2 1 M solution and then impregnated in 0.6 M KH 2 PO 4 solution. Templates then dried at 110 0 C for 2 h. Second, HA scaffold obtained used rattan template. Templates were prepared by cutting rattan into cylindrical shape. Slurry was prepared by mixing HA, sago, distilled water and Darvan 821 A. Templates then impregnated into slurry and stirred coincidely. Templates then dried at 110 0 C for 1 h. Both templates obtained pore sizes at range 100-500 μm. According to physical properties, it is clear that rattan is more suitable for using as template in replica method. Sample of HA scaffold that produced at stirring time for 12 h has more similar physical properties with bone implant than other samples.

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Hydroxyapatite Scaffolds Fabrication using Gambas Sponge ( Luffa cylindrica ) as Novel Template

Cited by 3 publications

References 0 publications

Molarity Effects of Fe and NaOH on Synthesis and Characterisation of Magnetite (Fe3O4) Nanoparticles for Potential Application in Magnetic Hyperthermia Therapy

Molarity Effects of Fe and NaOH on Synthesis and Characterisation of Magnetite (Fe3O4) Nanoparticles for Potential Application in Magnetic Hyperthermia Therapy

Response Surface Methodology Study on Macroporous Hydroxyapatite Prepared by Protein Foaming-Consolidation Method

Preparation of Porous Hydroxyapatite Bodies Using Bamboo and Rattan Templates

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