Hydroxychloroquine: A multifaceted treatment in lupus

Costédoat-Chalumeau, Nathalie; Dunogué, Bertrand; Morel, Nathalie; Guern, Véronique Le; Guettrot-Imbert, G.

doi:10.1016/j.lpm.2014.03.007

Cited by 159 publications

(186 citation statements)

References 127 publications

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“…El mecanismo por el cual HCQ ejerce su efecto inmunomodulador es complejo y no completamente aclarado. Se acepa que controla el proceso de autoinmunidad por varias vías, dentro de lo que se destaca su capacidad por interferir con la presentación de autoantígenos, bloquear la respuesta de linfocitos T inducida por antígenos, disminuir la producción de mediadores inflamatorios e inhibir la activación de los receptores Toll-like (TLR) 9 .…”

Section: Hidroxicloroquina-farmacología Clínicaunclassified

“…Esto determina, por ejemplo, en modelos experimentales de AR, una disminución en la producción de factor reumatoide. En experimentos básicos también se ha verificado que este efecto provoca disminución de otras moléculas inflamatorias involucradas en el daño tisular de la AR, el LES y otras EAS [9][10][11] . En los últimos tiempos se ha sugerido que la dosificación de los niveles plasmáticos de HCQ podría ser de utilidad en la monitorización del tratamiento.…”

Section: Hidroxicloroquina-farmacología Clínicaunclassified

“…La variabilidad intra e interindividual y la accesibilidad a la dosificación de niveles plasmáticos de HCQ dificulta la utilidad de esta técnica. Por el momento está establecido que su mayor utilidad es para verificar la adhesión al tratamiento 9 . La seguridad del tratamiento con HCQ ha sido largamente analizada.…”

Section: Hidroxicloroquina-farmacología Clínicaunclassified

“…Probablemente es en esta enfermedad donde más se ha avanzado en relación al conocimiento sobre sus beneficios terapéuticos. Su eficacia y seguridad ha sido ampliamente comprobada en varios estudios clínicos y sistematizada en diversas publicaciones 9,15 . Los beneficios más relevantes se resumen en la Tabla 1.…”

Section: Hidroxicloroquina En El Lupus Eritematoso Sistémicounclassified

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Hidroxicloroquina en el tratamiento de las enfermedades autoinmunes sistémicas

et al. 2016

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Section: Hidroxicloroquina-farmacología Clínicaunclassified

Section: Hidroxicloroquina En El Lupus Eritematoso Sistémicounclassified

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Hidroxicloroquina en el tratamiento de las enfermedades autoinmunes sistémicas

et al. 2016

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“…These pharmacological activities include DNA binding 4 , antitumor [5][6][7] , benzodiazepine and GABA receptor ligand activity 8 , antiviral 9,10 , antibacterial 11 , antituberculosis 12,13 and cellular phosphorylation and tyrosine kinase inhibition 14 . Many marketed drugs comprise quinazoline nucleus in their structures such as; , treatment of lupus 25 , treatment of neurodegenerative diseases 26 , antitubercular 27,28 , antiprotozoal 29,30 and anticancer 31,32 . Among the marketed drugs carrying quinoline nucleus is the fluoroquinolone antibacterial ciprofloxacin.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted benzo[h]quinazolines, benzo[h]quinolines and naphthaleno[d]thiazoles

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Zaghary

Amin

et al. 2017

Journal of Advanced Pharmacy Research

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Objectives: The notable advancing in the medicinal chemistry arena against infectious diseases has resulted in the discovery of numerous valuable antimicrobial drugs that saved millions of lives throughout the last few decades. Nevertheless, the continuous reporting of multi-drug resistant strains of a number of diverse germs makes the need for novel broad-spectrum anti-infective agents still exists. Methods: Three series of ring-equivalent tricyclic benzo The antimicrobial activity of some of the synthesized compounds was screened and only 2-bromo derivative IX and aminothiazole compound X exhibited broad antimicrobial effectiveness. The antifungal MIC value of X was1.85 mg/mL. Conclusion:The new synthesized compounds, designed as bioisosteres, showed excellent potency against the tested gram (+) bacterial and fungal strains compared to reference drugs.

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Disease Activity During Pregnancy and the First Year Postpartum in Women With Systemic Lupus Erythematosus

Skorpen

Lydersen

Gilboe

et al. 2017

Arthritis Care & Research

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Objective Disease activity measured by validated methods has been sparsely examined during and after pregnancy in women with systemic lupus erythematosus (SLE). The aim of this study was to describe the longitudinal course of disease activity during pregnancy and the first year postpartum using the Lupus Activity Index in Pregnancy (LAI‐P). Methods RevNatus is a nationwide Norwegian prospective observational register including women diagnosed with inflammatory rheumatic diseases. LAI‐P is a modified version of the LAI, with a good ability to assess disease activity in pregnant women with SLE. These indexes were used to assess disease activity at 6 visits (in trimesters 1, 2, and 3, and at 6 weeks, 6 months, and 12 months postpartum). The longitudinal course of disease activity was analyzed using an ordinal logistic mixed model. Results A total of 757 visits (145 pregnancies) in women with SLE were included in the analysis. More than half (51.6%) of the disease activity scores indicated remission, and only 6.3% indicated moderate disease activity. The model showed a statistically significant and clinically relevant change in disease activity over time, and a higher disease activity 6 and 12 months postpartum compared to the third trimester and 6 weeks postpartum. Conclusion The majority of women had low or no disease activity at conception and during pregnancy, with higher disease activity at 6 and 12 months after delivery. This points to the importance of tight disease control not only before and during pregnancy but also in the first year postpartum.

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Hydroxychloroquine: A multifaceted treatment in lupus

Cited by 159 publications

References 127 publications

Hidroxicloroquina en el tratamiento de las enfermedades autoinmunes sistémicas

Hidroxicloroquina en el tratamiento de las enfermedades autoinmunes sistémicas

Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted benzo[h]quinazolines, benzo[h]quinolines and naphthaleno[d]thiazoles

Disease Activity During Pregnancy and the First Year Postpartum in Women With Systemic Lupus Erythematosus

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