Hydroxylapatite nanorods: An efficient and promising carrier for gene transfection

Wu, Guojun; Zhou, Linzhu; Wang, Ke-wei; Chen, Feng; Sun, Ying; Duan, Yourong; Zhu, Yingjie; Gu, Hongchen

doi:10.1016/j.jcis.2010.01.048

Cited by 58 publications

(36 citation statements)

References 25 publications

(27 reference statements)

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“…The broad strong peak at around 3433 cm À 1 is assigned to the adsorbed water; the absorption band at about 3569 cm-1, which is not obvious due to overlapping with the strong band of adsorbed water, arises from the hydroxyl group in HAP [10]. The characteristic bands of PO 4 3À ions are located at 1093, 1030, 960, 606 and 561 cm À 1 [20].…”

Section: Resultsmentioning

confidence: 96%

Microwave-assisted hydrothermal rapid synthesis of hydroxyapatite nanowires using adenosine 5'-triphosphate disodium salt as phosphorus source

Tang

Zhu

et al. 2012

Materials Letters

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Section: Resultsmentioning

confidence: 96%

Microwave-assisted hydrothermal rapid synthesis of hydroxyapatite nanowires using adenosine 5'-triphosphate disodium salt as phosphorus source

Tang

Zhu

et al. 2012

Materials Letters

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“…The efficiency of the complex was determined by measuring the amount of DNA incorporated into the particles by using gel permeation chromatography and fluorescence measurements. Similarly, HA nanorods with a length of 100 nm and a diameter of 25 nm were synthesized by using a stabilizing block copolymer (PLGA-mPEG) and the DNA loading capacity was investigated [29]. In this study, first, HA nanorods were synthesized and then, the HA-DNA complex was obtained by quick mixing them together in the presence of CaCl 2 .…”

Section: The Use Of Calcium Phosphate Nanoparticles For Gene Therapymentioning

confidence: 99%

“…The strategy of using block copolymer and post-binding of HA nanorods with DNA make them remarkably efficient and safe gene vector [29]. Zhu et al [30] synthesized short HA nanorods with a length of 40-60 nm and then mixed them with EGFP-N1 pDNA to form the nanoparticle-DNA complex.…”

Section: The Use Of Calcium Phosphate Nanoparticles For Gene Therapymentioning

confidence: 99%

Gene Delivery by Hydroxyapatite and Calcium Phosphate Nanoparticles: A Review of Novel and Recent Applications

Bakan¹

2018

Hydroxyapatite - Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets

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Gene therapy is a targeted therapy which can be used in the treatment of various acquired and inherited diseases. Inhabitation of a gene function, restoring or improving a gene, or gaining a new function can be achieved by gene therapy strategies. The most crucial step in this therapy is delivering the therapeutic material to the target. Nanosized calcium phosphates (CaPs) have been considered as promising carriers due to their excellent biocompatibility. In this chapter, the delivery of DNA, siRNA, and miRNA by using CaP nanocarriers were compiled in detail and the main parameters which can affect the carrier properties and thus the gene transfer efficiency were also discussed.

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“…In the presence of Ca 2＋ , HAP nanorods exhibited ultrahigh DNA loading capacity. [118] Antibacterial application HAP nanorods and amorphous calcium phosphate (ACP) nanoparticles were prepared using CaCl 2 •2H 2 O and Na 2 HPO 4 •12H 2 O in aqueous solution and they were used as the nanocarriers for zinc ion loading. The extraction method conducted in ethanol was adopted for zinc ion loading.…”

Section: 1mentioning

confidence: 99%

Nanostructured Materials of Calcium Phosphates and Calcium Silicates: Synthesis, Properties and Applications

Zhu

2017

Chin. J. Chem.

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4-) and sometimes hydrogen or hydroxide ions. Calcium phosphates can be widely found in nature as well as in hard tissues (bone and tooth) of the vertebrate. Owing to similar chemical composition and structure to the main inorganic constituents of bone and tooth, calcium phosphate-based materials are promising biomaterials with high biocompatibility, and have been investigated for applications in various biomedical areas. Calcium silicate-based materials have attracted much attention on their potential applications in various biomedical fields such as bone defect repair and drug delivery. In recent years, this research group has been focusing on the research in this exciting and rapidly evolving research field, and has published many papers. This article will provide a brief review on our main research work on the synthesis, characterization, properties and applications of nanostructured materials of calcium phosphates and calcium silicates. Finally, future perspectives and challenges for the research and applications of nanostructured materials of calcium phosphates and calcium silicates are discussed.

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Hydroxylapatite nanorods: An efficient and promising carrier for gene transfection

Cited by 58 publications

References 25 publications

Microwave-assisted hydrothermal rapid synthesis of hydroxyapatite nanowires using adenosine 5'-triphosphate disodium salt as phosphorus source

Microwave-assisted hydrothermal rapid synthesis of hydroxyapatite nanowires using adenosine 5'-triphosphate disodium salt as phosphorus source

Gene Delivery by Hydroxyapatite and Calcium Phosphate Nanoparticles: A Review of Novel and Recent Applications

Nanostructured Materials of Calcium Phosphates and Calcium Silicates: Synthesis, Properties and Applications

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