Hydroxypropyl cellulose as a green polymer for thermo-responsive aqueous foams

Weißenborn, Eric; Braunschweig, Björn

doi:10.1039/c9sm00093c

Cited by 57 publications

(41 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[7][8][9][10][11] For example, tuning the properties of uid interfaces helps to develop smart foams with self-healing and adaptive functions. 3,12 In addition, Marangoni ows can be used to pattern or aggregate particles precisely and independently of their size in the tailoring of 2D colloidal crystals. 13,14 Previous work on photoswitchable surfactants that undergo photo-isomerization reactions from E to Z conformations when irradiated with UV and blue light has concentrated mostly on non-ionic azo surfactants with surface tension changes as high as $29 mN m À1 upon photoswitching.…”

Section: Introductionmentioning

confidence: 99%

Unexpected monolayer-to-bilayer transition of arylazopyrazole surfactants facilitates superior photo-control of fluid interfaces and colloids

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Unexpected monolayer-to-bilayer transition of arylazopyrazole surfactants facilitates superior photo-control of fluid interfaces and colloids

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…This concept is similar to foams stabilized by thermo-responsive polymers such as hydroxypropyl cellulose. 9 Although, the lifetime of the spiropyrane and the merocyanine sulfonate stabilized foams presented in our study is short compared to the systems noted above, it is possible to change locally the color of the foam. This can be accomplished e.g.…”

Section: Resultsmentioning

confidence: 61%

Spiropyran Sulfonates for Photo- and pH-Responsive Air–Water Interfaces and Aqueous Foam

et al. 2020

Self Cite

View full text Add to dashboard Cite

Responsive foams and interfaces, are interesting building blocks for active materials that respond and adapt to external stimuli. We have used the photochromic reaction of a spiropyran sulfonate surfactant to render interfacial, rising bubble as well as foaming properties active to light stimuli.In order to address the air-water interface on a molecular level, we have applied sum-frequency generation (SFG) spectroscopy which has provided qualitative information on the surface excess and the interfacial charging state as a function of light irradiation and solution pH. Under blue light irradiation, the surfactant forms a closed ring spiro form (SP), whereas under dark conditions the ring opens and the merocyanine (MC) form is generated. Using SFG spectroscopy, we show that at the interface, different pH conditions of the bulk solution lead to changes in the interfacial charging state. We have exploited the fact that the MC surfactant's O-H group can be deprotonated as a function of pH, and used that to tune the molecules net charge at the interface. In fact, SFG spectroscopy shows that with increasing pH the intensity of the O-H stretching band from interfacial water molecules increases which we associate to an increase in surface net charge. At a pH of 5.3, irradiation with blue light leads to a reversible decrease of O-H intensities, whereas the C-H intensities were unchanged compared to the corresponding intensities under dark conditions. These results are indicative of changes in the surface net charge with light irradiation, which are also expected to influence the foam stability via changes in the electrostatic disjoining pressure. In fact, measurements of the foam stabilities are consistent with this hypothesis with higher foam stability under dark conditions. At pH 2.7 this behavior is reversed as far as the surface tension and surface charging as well as the foam stability are concerned. This is corroborated by rising bubble experiments, which demonstrated an unprecedented reduction of ~30 % in bubble velocity when the bubbles were irradiated with blue light compared to the velocity of bubbles with the

show abstract

“…[35][36][37] Hydrogels based on hydroxypropyl cellulose (HPC) have attracted intense attention due to several advantages of HPC such as the commercial derivative of cellulose, the abundant renewable resource, no cytotoxicity and approval by the Food and Drug Administration (FDA). 30 The photocrosslinked HPC hydrogels have been developed as a biocompatibility substrate for cell sheet engineering. 26 In this study, their role was extended to serve as a vehicle for drug delivery.…”

Section: Discussionmentioning

confidence: 99%

“…28,29 HPC, the most abundant renewable polysaccharide in nature, has been approved by the Food and Drug Administration (FDA) as drug delivery substrate. 30 In this study, we prepared HPC hydrogels by an easy irradiation technique for controlled protein release. The HPC hydrogels exhibited a porous structure, consisting of open pore channels and an interconnected framework (Figure 2A).…”

Section: Characterization Of Hpc Hydrogelsmentioning

confidence: 99%

<p>Superior Antitumor Efficacy of IFN-α2b-Incorporated Photo-Cross-Linked Hydrogels Combined with T Cell Transfer and Low-Dose Irradiation Against Gastric Cancer</p>

Liu

Zhang

et al. 2020

IJN

View full text Add to dashboard Cite

The exhaustion and poor homing of activated lymphocytes are critical obstacles in adoptive cell immunotherapy for solid tumors. In order to effectively deliver immune cells into tumors, we encapsulated interferon-α2b (IFN-α2b) into macroporous hydrogels as an enhancement factor and utilized low-dose irradiation (LDI) as a tumoral attractor of T cells. Methods: Hydroxypropyl cellulose hydrogels were prepared by irradiation techniques, and the cross-sectional microstructure was characterized by scanning electron microscopy. The synergistic antitumor mechanism of combination of IFN-α2b and CIK cells was evaluated by detecting the expression of activation marker CD69 on CIK cell surface and IFN-γ production by CIK cells. The in vivo antitumor activity of IFN-α2b-incorporated hydroxypropyl cellulose hydrogels combined with CIK and radiation was evaluated in an MKN-45 xenografted nude mice model. Results: The bioactivity of IFN-α2b was well maintained in ultraviolet-reactive, rapidly cross-linkable hydroxypropyl cellulose hydrogels. In vitro studies demonstrated IFN-α2bactivated T cells, as evidenced by upregulating early activation marker CD69 and secretion inflammatory cytokine IFN-γ. In vivo real-time image showed our hydrogels kept a higher amount of drug delivery at the tumor site for a long time compared with free drug injection. Low-dose irradiation promoted T cell accumulation and infiltration in subcutaneous tumors. Combination of IFN-α2b-loaded hydrogels (Gel-IFN) with T cells and LDI exhibited higher efficacy to eradicate human gastric cancer xenograted tumors with less proliferating cells and more necrotic regions compared with IFN-α2b or T cells alone. Discussion: HPC hydrogels kept the activity of IFN-α2b and stably release of IFN-α2b to stimulate T cells for a long time. At the same time, low-dose radiation recruits T cells into tumors. This innovative integration mode of IFN-α2b-loaded hydrogels and radiotherapy offers a potent strategy to improve the therapeutic outcome of T cell therapy.

show abstract

Hydroxypropyl cellulose as a green polymer for thermo-responsive aqueous foams

Abstract: Hydroxypropyl cellulose (HPC) is a surface active polymer that can change its solubility as a function of temperature.

Cited by 57 publications

References 55 publications

Unexpected monolayer-to-bilayer transition of arylazopyrazole surfactants facilitates superior photo-control of fluid interfaces and colloids

Unexpected monolayer-to-bilayer transition of arylazopyrazole surfactants facilitates superior photo-control of fluid interfaces and colloids

Spiropyran Sulfonates for Photo- and pH-Responsive Air–Water Interfaces and Aqueous Foam

<p>Superior Antitumor Efficacy of IFN-α2b-Incorporated Photo-Cross-Linked Hydrogels Combined with T Cell Transfer and Low-Dose Irradiation Against Gastric Cancer</p>

Contact Info

Product

Resources

About