Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury

Wang, Yang; Zhang, Chunhu; Peng, Weijun; Xia, Zian; Gan, Pingping; Huang, Wei; Shi, Yafei; Fan, Rong

doi:10.3892/mmr.2016.5720

Cited by 41 publications

(39 citation statements)

References 44 publications

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“…The effect of hydroxysafflor yellow A (HSYA), a constituent of the flower petals of Carthamus tinctorius , on a CCI model of TBI showed that HSYA increased the activities of SOD and CAT, the level of glutathione (GSH) and the GSH/glutathione disulfide (GSSG) ratio, and decreased the levels of MDA and GSSG …”

Section: Resultsmentioning

confidence: 99%

“…88 The effect of hydroxysafflor yellow A (HSYA), a constituent of the flower petals of Carthamus tinctorius, on a CCI model of TBI showed that HSYA increased the activities of SOD and CAT, the level of glutathione (GSH) and the GSH/glutathione disulfide (GSSG) ratio, and decreased the levels of MDA and GSSG. 12 3.6 | Cinnamomum zeylanicum C. zeylanicum is commonly known as cinnamon, belonging to the Lauraceae family. The major components of the essential oil of C. zeylanicum are trans-cinnamaldehyde, eugenol, and linalool.…”

Section: Carthamus Tinctoriusmentioning

confidence: 99%

“…11 When the antioxidant effect of C. tinctorius was studied, it was shown that HSYA by reduction of oxidant markers and enhancement of antioxidant markers could be a potential neuroprotective medication in the cases of TBI. 12 In a CI model of TBI, it was shown that cinnamon could play an important role in reducing infarct and edema formation through modulation of Nfr2 and cytokine expression. This also reduces oxidative stress and could exert neuroprotective activity through these mechanisms.…”

Section: Molecular Mechanisms Underlying the Neuroprotective Effectmentioning

confidence: 99%

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Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

et al. 2019

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Traumatic brain injury (TBI) is the most prevalent health problem affecting all age groups, and leads to many secondary problems in other organs especially kidneys, gastrointestinal tract, and heart function. In this review, the search terms were TBI, fluid percussion injury, cold injury, weight drop impact acceleration injury, lateral fluid percussion, cortical impact injury, and blast injury. Studies with Actaea racemosa, Artemisia annua, Aframomum melegueta, Carthamus tinctorius, Cinnamomum zeylanicum, Crocus sativus, Cnidium monnieri, Curcuma longa, Gastrodia elata, Malva sylvestris, Da Chuanxiong Formula, Erigeron breviscapus, Panax ginseng, Salvia tomentosa, Satureja khuzistanica, Nigella sativa, Drynaria fortune, Dracaena cochinchinensis, Polygonum cuspidatum, Rosmarinus officinalis, Rheum tanguticum, Centella asiatica, and Curcuma zedoaria show a significant decrease in neuronal injury by different mechanisms such as increasing superoxide dismutase and catalase activities, suppressing nuclear factor kappa B (NF‐κB), interleukin 1 (IL‐1), glial fibrillary acidic protein, and IL‐6 expression. The aim of this study was to evaluate the neuroprotective effects of medicinal plants in central nervous system pathologies by reviewing the available literature.

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Section: Resultsmentioning

confidence: 99%

Section: Carthamus Tinctoriusmentioning

confidence: 99%

Section: Molecular Mechanisms Underlying the Neuroprotective Effectmentioning

confidence: 99%

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Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

et al. 2019

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“…Recent studies have demonstrated that SY and HSYA possess multiple pharmacological functions, including antioxidation, antiinflammation, anti-thrombosis, anti-coagulation, anti-tumor, anti-apoptosis, neuroprotection, and protection of endothelial cells (Fan et al, 2014;Zhang et al, 2016). The antioxidant effects of SY and HSYA have been reported in rat model of traumatic brain injury (Wang et al, 2016), HepG2 cells with oxidative damage (Ma et al, 2016), and pancreatic b-cells (Zhao et al, 2018). In our previous study, SY has been found to possess the anti-obesity effects (Zhu et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Safflower Yellow and Its Main Component HSYA Alleviate Diet-Induced Obesity in Mice: Possible Involvement of the Increased Antioxidant Enzymes in Liver and Adipose Tissue

et al. 2020

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Purpose: Oxidative stress plays an important role in the pathogenesis of obesity and its associated disorders. Safflower yellow (SY) and hydroxysafflor yellow A (HSYA), the natural compounds isolated from Carthamus tinctorius L., has been found to possess antioxidative and anti-obesity properties. The purpose of the present study is to investigate whether SY and its main component HSYA alleviate obesity by the antioxidant effects. Methods: Diet-induced obese (DIO) mice were treated with 200 mg/kg/d SY or HSYA for 10 weeks. Body weight, fat mass, serum biochemical parameters and superoxide dismutase (SOD) activities were measured. Glucose and insulin tolerance tests were performed. The expression of antioxidant enzymes in liver and adipose tissue were measured. In vitro, H 2 O 2-induced oxidative stress HepG2 cells and 3T3-L1 adipocytes were treated with SY and HSYA to investigate the direct effects of SY and HSYA on the expression of antioxidant enzymes. Results: SY and HSYA significantly decreased the body weight gain of DIO mice, and decreased fat mass to 57.8% and 61.6% of the control mice, respectively (P < 0.05). The parameters of glucose metabolism and liver function were improved after SY and HSYA treatment. The hepatic SOD activities and the mRNA levels of antioxidant enzymes in liver and adipose tissue of SY and HSYA treated mice were increased (P < 0.05). Meanwhile, the administration of SY and HSYA on the H 2 O 2-induced oxidative stress HepG2 cells and adipocytes also increased the expression of the antioxidant factor and antioxidant enzymes to 1.2~3.3 folds of the control cells (P < 0.05). Conclusion: SY and its main component HSYA could significantly decrease the fat mass, and improve glucose metabolism and liver function in diet-induced obese mice. The

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“…Hydroxysafflor Yellow A (HSYA), a most representative and water‐soluble ingredient of Carthamus tinctorius L., has long been used in the treatment of myocardial ischaemia in China and exhibits prominently antiplatelet, anti‐inflammatory, antioxidant and pro‐angiogenic activities 10, 11, 12, 13. What is worth to be mentioned is the pro‐angiogenic effect of HSYA which has been reported in different ischaemic models recently 12, 14.…”

Section: Introductionmentioning

confidence: 99%

Nucleolin mediated pro‐angiogenic role of Hydroxysafflor Yellow A in ischaemic cardiac dysfunction: Post‐transcriptional regulation of VEGF‐A and MMP‐9

Zou

Wang

Liu

et al. 2018

J Cellular Molecular Medi

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Hydroxysafflor Yellow A (HSYA), a most representative ingredient of Carthamus tinctorius L., had long been used in treating ischaemic cardiovascular diseases in China and exhibited prominently anticoagulant and pro‐angiogenic activities, but the underlying mechanisms remained largely unknown. This study aimed to further elucidate the pro‐angiogenic effect and mechanism of HSYA on ischaemic cardiac dysfunction. A C57 mouse model of acute myocardial infarction (AMI) was firstly established, and 25 mg/kg HSYA was intraperitoneally injected immediately after operation and given once, respectively, each morning and evening for 2 weeks. It was found that HSYA significantly improved ischaemia‐induced cardiac haemodynamics, enhanced the survival rate, alleviated the myocardial injury and increased the expressions of CD31, vascular endothelial growth factor‐A (VEGF‐A) and nucleolin in the ischaemic myocardium. In addition, HSYA promoted the migration and tube formation of human umbilical vein endothelial cells (HUVECs), enhanced the expressions of nucleolin, VEGF‐A and matrix metalloproteinase‐9 (MMP‐9) in a dose‐ and time‐dependent manner. However, down‐regulation of nucleolin expression sharply abrogated the effect mentioned above of HSYA. Further protein‐RNA coimmunoprecipitation and immunoprecipitation‐RT‐PCR assay showed that nucleolin binded to VEGF‐A and MMP‐9 mRNA and overexpression of nucleolin up‐regulated the mRNA expressions of VEGF‐A and MMP‐9 in the HUVECs through enhancing the stability of VEGF‐A and MMP‐9 mRNA. Furthermore, HSYA increased the mRNA expressions of VEGF‐A and MMP‐9 in the extract of antinucleolin antibody‐precipitated protein from the heart of AMI mice. Our data revealed that nucleolin mediated the pro‐angiogenic effect of HSYA through post‐transcriptional regulation of VEGF‐A and MMP‐9 expression, which contributed to the protective effect of HSYA on ischaemic cardiac dysfunction.

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Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury

Cited by 41 publications

References 44 publications

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

Safflower Yellow and Its Main Component HSYA Alleviate Diet-Induced Obesity in Mice: Possible Involvement of the Increased Antioxidant Enzymes in Liver and Adipose Tissue

Nucleolin mediated pro‐angiogenic role of Hydroxysafflor Yellow A in ischaemic cardiac dysfunction: Post‐transcriptional regulation of VEGF‐A and MMP‐9

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