Hydroxysafflor Yellow A Promoted Bone Mineralization and Inhibited Bone Resorption Which Reversed Glucocorticoids-Induced Osteoporosis

Liu, Li; Tao, Weiwei; Pan, Wenjia; Li, Li; Yu, Qunli; Zhang, Dawei; Jiang, Jun

doi:10.1155/2018/6762146

Cited by 21 publications

(16 citation statements)

References 37 publications

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“…The results showed that HSYA exhibited a remarkable protective effect on OVX-induced osteoporosis in a rat model as confirmed by micro-CT and histological and immune-histochemical analysis. This finding is consistent with the previous report that HSYA could inhibit bone resorption and reverse glucocorticoid induced bone loss in zebrafish [38].…”

Section: Discussionsupporting

confidence: 94%

Hydroxysafflor yellow A promotes osteogenesis and bone development via epigenetically regulating β-catenin and prevents ovariectomy-induced bone loss

Wang

Zhuo

et al. 2020

Preprint

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In clinical treatment, there is increasingly prevalent that traditional Chinese medicine treats common bone diseases including osteoporosis. Hydroxy safflor yellow A (HSYA), one of the essential compounds of Safflower, has strong effects to scavenge oxidative stress and inhibit apoptosis. It has been used as the therapy for thrombus, myocardial ischemia, and inflammation, but its effect on osteoporosis has not been explored. In this study, we found HSYA could enhance the cell viability and promote osteogenesis of hBMSC in vitro. Mechanistically, HSYA could increase the expression of β-catenin leading to its accumulation in the nucleus and activation of down-stream targets to promote osteogenesis. In addition, RNAseq and quantitative RT-PCR showed KDM7A was significantly increased by HSYA.The occupancy of H3K27me2 on β-catenin promoter was significantly decreased by HSYA, which could be reversed by silencing endogenous KDM7A. More importantly, HSYA could promote bone development in chick embryos and prevent ovariectomy(OVX)-induced bone loss in SD rats. Taken together, our study has shown convincing evidence that HSYA can promote osteogenesis and bone development via epigenetically regulating β-catenin and prevents ovariectomy-induced bone loss. HSYA might be used to treat some skeletal diseases such as osteoporosis.

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Section: Discussionsupporting

confidence: 94%

Hydroxysafflor yellow A promotes osteogenesis and bone development via epigenetically regulating β-catenin and prevents ovariectomy-induced bone loss

Wang

Zhuo

et al. 2020

Preprint

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“…For example, some of the genera that increased in abundance with the HLA diet are known short chain fatty acid producers including Akkermansia, Butyricimonas, Coprococcus and members of the Clostridiales order. Abundance of Akkermansia and especially the species Akkermansia muciniphila abundance has previously been linked to dietary fat intake, although this relationship is complex, with both increased and decreased abundance has been reported depending on the type of lipid, the overall composition of the diet or the presence of additional treatments (22,24,31,34). In general however, Akkermansia abundance is negatively correlated with dietary fat intake (30).…”

Section: Discussionmentioning

confidence: 99%

Pregnancy and diet-related changes in the maternal gut microbiota following exposure to an elevated linoleic acid diet

Shrestha

Sleep

Cuffe

et al. 2020

American Journal of Physiology-Endocrinology and Metabolism

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Dietary intakes of linoleic acid (LA) have increased, including in women of reproductive age. Changes in maternal gut microbiome have been implicated in the metabolic adaptions that occur during pregnancy. We aimed to investigate whether consumption of a diet with elevated LA altered fecal microbiome diversity before and during pregnancy. Female Wistar-Kyoto rats consumed a high-LA diet (HLA: 6.21% of energy) or a low-LA diet (LLA: 1.44% of energy) for 10 wk before mating and during pregnancy. DNA was isolated from fecal samples before pregnancy [embryonic day 0 (E0)], or during pregnancy at E10 and E20. The microbiome composition was assessed with 16S rRNA sequencing. At E0, the beta-diversity of LLA and HLA groups differed with HLA rats having significantly lower abundance of the genera Akkermansia, Peptococcus, Sutterella, and Xo2d06 but higher abundance of Butyricimonas and Coprococcus. Over gestation, in LLA but not HLA rats, there was a reduction in alpha-diversity and an increase in beta-diversity. In the LLA group, the abundance of Akkermansia, Blautia, rc4.4, and Streptococcus decreased over gestation, whereas Coprococcus increased. In the HLA group; only the abundance of Butyricimonas decreased. At E20, there were no differences in alpha- and beta-diversity, and the abundance of Roseburia was significantly increased in the HLA group. In conclusion, consumption of a HLA diet alters gut microbiota composition, as does pregnancy in rats consuming a LLA diet. In pregnancy, consumption of a HLA diet does not alter gut microbiota composition.

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“…The injection of HSYA at different concentrations (0.1, 1.0, and 10.0 μM) prevented bone mineralization, osteoblasts viability, and inhibited bone resorption. In vivo, the effect of HSYA on bone formation and glucocorticoids-induced osteoporosis (GCIOP) was demonstrated using zebrafish [ 90 ]. The effects of crude extract of safflower seed were examined on osteoblast differentiation and intracellular calcium ion concentration in MC3T3-E1 cells, showing the ability to prevent osteoporosis and protect against bone loss [ 91 ].…”

Section: Safflower Pharmacological Activitymentioning

confidence: 99%

A Metabolic Perspective and Opportunities in Pharmacologically Important Safflower

et al. 2020

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Safflower (Carthamus tinctorius L.) has long been grown as a crop due to its commercial utility as oil, animal feed, and pharmacologically significant secondary metabolites. The integration of omics approaches, including genomics, transcriptomics, metabolomics, and proteomics datasets, has provided more comprehensive knowledge of the chemical composition of crop plants for multiple applications. Knowledge of a metabolome of plant is crucial to optimize the evolution of crop traits, improve crop yields and quality, and ensure nutritional and health factors that provide the opportunity to produce functional food or feedstuffs. Safflower contains numerous chemical components that possess many pharmacological activities including central nervous, cardiac, vascular, anticoagulant, reproductive, gastrointestinal, antioxidant, hypolipidemic, and metabolic activities, providing many other human health benefits. In addition to classical metabolite studies, this review focuses on several metabolite-based working techniques and updates to provide a summary of the current medical applications of safflower.

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Hydroxysafflor Yellow A Promoted Bone Mineralization and Inhibited Bone Resorption Which Reversed Glucocorticoids-Induced Osteoporosis

Cited by 21 publications

References 37 publications

Hydroxysafflor yellow A promotes osteogenesis and bone development via epigenetically regulating β-catenin and prevents ovariectomy-induced bone loss

Hydroxysafflor yellow A promotes osteogenesis and bone development via epigenetically regulating β-catenin and prevents ovariectomy-induced bone loss

Pregnancy and diet-related changes in the maternal gut microbiota following exposure to an elevated linoleic acid diet

A Metabolic Perspective and Opportunities in Pharmacologically Important Safflower

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