Hydroxytyrosol: A natural compound with promising pharmacological activities

Bertelli, Matteo; Kiani, Aysha Karim; Paolacci, Stefano; Manara, Elena; Kurti, Danjela; Dhuli, Kristjana; Bushati, Vilma; Miertuš, Ján; Pangallo, Domenico; Baglivo, Mirko; Beccari, Tommaso; Michelini, Sandro

doi:10.1016/j.jbiotec.2019.12.016

Cited by 175 publications

(138 citation statements)

References 50 publications

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“…Pinoresinol has shown antifungal activity against several pathogenic fungi such as Fusarium verticillioides, Fusarium graminearum and Candida albicans [121]. Additionally, oleuropein and hydroxytyrosol were found to be effective against fungi and several strains of bacteria, viruses, including human immunodeficiency viruses (HIV) and parasites [151,153].…”

Section: Other Bioactivitiesmentioning

confidence: 99%

Bioactive Compounds and Quality of Extra Virgin Olive Oil

Jiménez-López

Carpena

Gallardo-Gómez

et al. 2020

Foods

310

235

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(1) Background: Extra virgin olive oil (EVOO) is responsible for a large part of many health benefits associated to Mediterranean diet as it is a fundamental ingredient of this diet. The peculiarities of this golden, highly valued product are in part due to the requirements that must be met to achieve this title, namely, it has to be obtained using exclusively mechanical procedures, its free acidity cannot be greater than 0.8%, it must not show sensory defects, and it has to possess a fruity taste. (2) Methods: All these characteristics are key factors to EVOO quality, thus the chemical composition of these many health-promoting compounds, such as unsaturated fatty acids (which are also the major compounds, especially oleic acid), as well as minor components such as tocopherols or phenolic compounds (which behave as natural antioxidants) must be preserved. (3) Results: Due to the presence of all these compounds, the daily consumption of EVOO entails health benefits such as cardioprotective, antioxidant, anti-inflammatory, anti-tumor properties or acting as regulator of the intestinal microbiota, among others. (4) Conclusions: Taking all together, conserving EVOO chemical composition is essential to preserve its properties, so it is worth to control certain factors during storage like exposure to light, temperature, oxygen presence or the chosen packaging material, to maintain its quality and extend its shelf-life until its consumption.

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Section: Other Bioactivitiesmentioning

confidence: 99%

Bioactive Compounds and Quality of Extra Virgin Olive Oil

Jiménez-López

Carpena

Gallardo-Gómez

et al. 2020

Foods

310

235

View full text Add to dashboard Cite

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“…These PCs lower the blood pressure of the hypertensive rats by reducing angiotensin-converting enzyme, cholinesterase, and arginase activity. Hydroxytyrosol has been reported to possess significant cardio-protective properties (Bertelli et al, 2020). Both syringic acid and resveratrol produce cardio-protective effects by lowering total cholesterol, triglycerides, low-density lipoprotein cholesterol, verylow-density lipoprotein cholesterol, and TBARS and a significant decrease in high-density lipoprotein cholesterol in serum and heart (Manjunatha et al, 2020).…”

Section: Cardio-protective Propertiesmentioning

confidence: 99%

Concept, mechanism, and applications of phenolic antioxidants in foods

2020

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In this review, the concept of phenolic antioxidants, mechanisms of action, and applications have been reviewed. Phenolic compounds (PCs) acts as an antioxidant by reacting with a variety of free radicals. The mechanism of antioxidant actions involved either by hydrogen atom transfer, transfer of a single electron, sequential proton loss electron transfer, and chelation of transition metals. In foods, the PCs act as antioxidants which are measured with several in vitro spectroscopic methods. The PCs have been found in milk and a wide range of dairy products with sole purposes of color, taste, storage stability, and quality enhancement. The role of PCs in three types of food additives, that is, antimicrobial, antioxidant, and flavoring agents have been critically reviewed. The literature revealed that PCs present in a variety of foods possess several health benefits such as antibacterial, antihyperlipidemic, anticancer, antioxidants, cardioprotective, neuroprotective, and antidiabetic properties. Practical applications Phenolic compounds are strong antioxidants and are safer than synthetic antioxidants. The wide occurrence in plant foods warranted continuous review applications. This review, therefore, presented an updated comprehensive overview of the concept, mechanism, and applications of phenolic antioxidants in foods.

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“…The higher oxidation inhibition was reached using 100 ppm HT (Figure 1). Exerting neuroprotective, anti-inflammatory, anticancer and even antiviral (against several influenza A viruses [19]) activities, hydroxytyrosol abundant in Olea europea was recently found to be "the most actively investigated natural phenol" [20].…”

Section: The Case For Synergy Between Olive Biophenols and Omega-3 LImentioning

confidence: 99%

Sustainably Sourced Olive Polyphenols and Omega-3 Marine Lipids: A Synergy Fostering Public Health

Pagliaro

Pizzone

Scurria

et al. 2020

Preprint

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Thanks to the pioneering studies of Østerud and co-workers it is now increasingly understood that natural polyphenols present in marine oils play an essential role in protecting omega-3 lipids from oxidation and autooxidation ensuring that no proinflammatory products are formed after intake as it often happens with assumption of refined omega-3 concentrates. Strong antioxidants exerting multiple biological functions, olive biophenols are ideally suited to functionalize marine oils creating a synergy which has the potential to foster public health across the world. This study identifies suitable avenues to advance the sustainable production of health-beneficial formulations based on newly obtained natural marine oils and olive phenolic extracts. Important educational outcomes for bioeconomy educators conclude the study.

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Hydroxytyrosol: A natural compound with promising pharmacological activities

Cited by 175 publications

References 50 publications

Bioactive Compounds and Quality of Extra Virgin Olive Oil

Bioactive Compounds and Quality of Extra Virgin Olive Oil

Concept, mechanism, and applications of phenolic antioxidants in foods

Sustainably Sourced Olive Polyphenols and Omega-3 Marine Lipids: A Synergy Fostering Public Health

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