Hylan Versus Corticosteroid Versus Placebo for Treatment of Basal Joint Arthritis: A Prospective, Randomized, Double-Blinded Clinical Trial

Hand Osteoarthritis: An Update on Therapy

“…To investigate that, as well as compare its effect with that of a corticosteroid injection, a prospective, double-blind RCT was conducted. 39 No statistically significant differences among hylan, steroid, and placebo injections were found for most of the outcome measure, such as pain at any time, symptoms at 26 weeks, Disabilities of the Arm, Shoulder, and Hand scores, and range of motion. However, due to the durable pain relief, improvement in symptoms, and enhanced grip strength compared to the preinjection state, hylan injections do have a role in the management of TM OA.…”

Hyaluronic Acid in the Treatment of Osteoarthritis: What is New

“…Beside pain reduction, also grip strength improved significantly in some studies (Migliore et al, 2010), although these effects were achieved slowly, with better results observed at 6 months (Fuchs et al, 2006;Heyworth et al, 2008;Stahl et al, 2005). In our experience (Table 4), a single ultrasound guided injection of hyaluronic acid is effective in treatment of carpo -metacarpal osteoarthritis (Salini et al, 2009).…”

“…In particular, an early improvement in Visual Analogic Scale score was observed after 2 weeks post treatment (Heyworth et al, 2008), with the effects lasting until 1 -3 months (Coaccioli et al, 2006;Roux et al, 2007;Schumacher et al, 2004;Stahl et al, 2005). The long term effects of hyaluronan were demonstrated only in few studies (Fuchs et al, 2006;Heyworth et al, 2008;), in which the pain relief was reported at 6 months (Di Sante et al, 2011).…”

Reflections on the American College of Rheumatology recommendations for osteoarthritis from the French Section on Osteoarthritis: Comment on the article by Hochberg et al

“…Concerning the trapeziometacarpal joint, the ACR recommended not using intraarticular therapies. Indeed, the level of evidence for intraarticular injections in rhizarthrosis is weak (2). However, in daily practice, intraarticular injections of a corticosteroid (0.5 ml) for the treatment of flares in rhizarthrosis can be effective in patients with good tolerance and could be regarded as an alternate option before considering surgery.…”

“…In a systematic review, Gonzalez-Perez and Rodriguez found that among those receiving acetaminophen Ͼ2 gm daily, the relative risk (RR) of upper gastrointestinal complications was 3.6 (95% confidence interval [95% CI] 2.6 -5.1), whereas smaller doses did not increase this risk (2). Garcia Rodriguez and Hernandez-Diaz performed a nested case-control study (2,105 patients and 11,500 control subjects) and found an increased risk of upper gastrointestinal complications among those currently receiving acetaminophen at a dose of Ͼ2 gm (RR 3.7 [95% CI 2.6 -5.1]), while finding no increased risk for those receiving a dose of Ͻ2 gm (RR 0.9 [95% CI 0.8 -1.1]) (3).…”