Hymenoptera Sensitivity Occurring in Families

Abstract

A total of248 patients with systemic reactions to Hymenoptera envenomation were studied. There were 138 adults and 110 children. Twenty-eight of these 248 (11.3%) had family members with histories consistent with Hymeno[Jlera anaphylaxis. These included jive mothers and sons, two sister pairs, three pairs of sister-brother, one pair brother-brother, and one pair father-daughter. In one extendedfami/y, afather, mother, son, and mother's sister had Hymenoptera sensitivity. Ninetysix consecutive allergic patients without Hymenoptera sensitivity served as controls, and of these, 3.1% had family members with Hymenoptera sensitivity. The occurrence of Hymenoptera sensitivity in families of patients with Hymenoptera sensitivity is statistically different from our controls (11.3% vs 3.1%, p = 0.0195). There appears to be a hereditary aspect for Hymenoptera sting sensitivity. (Allergy Proc 15:53-56, 1994)