Hyper- and hypothyroidism in pigeons fed DDT: An explanation for the ‘thin eggshell phenomenon’

Jefferies, D. J.; French, M. C.

doi:10.1016/0013-9327(71)90006-1

Cited by 49 publications

(15 citation statements)

References 12 publications

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“…In general, PCB mixtures increase the metabolism and excretion of TH and lower the circulating T 4 levels [19]. This response was first demonstrated by Batomsky et al [20] and is fairly consistent across a variety of mammals [21–25] and birds [26,27]. In rats, enhanced plasma clearance and lower circulating T 4 likely are related to the ability of PCB mixtures like Aroclor 1254 and Kanechlor 400 (CAS 12737–80–0) to induce T 4 glucuronidation [28,29].…”

Section: Studies Of Thyroid Disruptionmentioning

confidence: 91%

Contaminant effects on the teleost fish thyroid

Brown

Adams

Cyr

et al. 2004

Enviro Toxic and Chemistry

227

139

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Abstract-Numerous environmentally relevant chemicals, including polychlorinated hydrocarbons, polycyclic aromatic hydrocarbons, organochlorine pesticides, chlorinated paraffins, organophosphorous pesticides, carbamate pesticides, cyanide compounds, methyl bromide, phenols, ammonia, metals, acid loads, sex steroids, and pharmaceuticals, exert acute or chronic effects on the thyroid cascade in the approximately 40 teleost fish species tested to date. Thyroid endpoints, therefore, serve as biomarkers of exposure to environmental pollutants. However, the mechanisms underlying thyroid changes and their physiological consequences are poorly understood because the thyroid cascade may respond indirectly and it has considerable capacity to compensate for abuses that otherwise would disrupt thyroid hormone homeostasis. Indeed, a xenobiotic-induced change in fish thyroid function has yet to be conclusively causally linked to decreased fitness or survival. Other complications in interpretation arise from the diversity of test conditions employed and the often indiscriminate use of numerous thyroid endpoints. Future work should be directed toward standardizing test conditions and thyroid endpoints and investigating causal links between thyroid changes and fish growth, reproduction, and development. Development may be particularly susceptible to thyroid disruption, and thyroid endpoints appropriate for early life stages need to be applied.

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Section: Studies Of Thyroid Disruptionmentioning

confidence: 91%

Contaminant effects on the teleost fish thyroid

Brown

Adams

Cyr

et al. 2004

Enviro Toxic and Chemistry

227

139

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“…Species differences Jefferies and co-workers (Jefferies and French, 1971;Jefferies andParslow, 1972, 1976) examined the effects of DDT, DOE and dieldrin on the thyroid of the pigeon, and of PCBs on the lesser black-backed gull and the common guillemot (or murre). They found that the guillemot was considerably more sensitive to PCBs than the lesser black-backed gull in that the guillemot exhibited the same effects more than twice as rapidly.…”

Section: Factors Influencing Activitymentioning

confidence: 99%

Animal Biomarkers as Pollution Indicators

Peakall¹

1992

259

175

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“…We nevertheless found significant plasma T3 and T4 reductions at, respectively, 7 and 10 days after a single CB-77 dose. A reduction of thyroidhormone levels in birds by PCBs has been demonstrated before in experiments with black-backed gulls (Larus fuscus), pigeons (Jefferies & French, 1971) and Japanese quail (Coturnix coturnix;Gr/assle & Biessmann, 1982). In field studies a correlation between PCB-body burdens and thyroid-hormone levels has been demonstrated in common tern (Murk et al, 1993) and cormorants (Van den Berg et al, 1993).…”

Section: Thyroid Hormonesmentioning

confidence: 60%

Toxic and biochemical effects of 3,3′,4,4′-tetrachlorobiphenyl (CB-77) and clophen A50 on eider duckling (Somateria mollissima) in a semi-field experiment

Murk¹,

Berg²,

Fellinger³

et al. 1994

Environmental Pollution

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Toxic and biochemical effects of 3,3',4,4'-tetrachlorobiphenyl (CB-77) and Clophen A50 on eider ducklings (Somateria mollissima) in a semi-field experiment. Murk, A.J.; van den Berg, J.H.H.; Fellinger, M.; Rozemeijer, M.J.C.; Swennen, C.; Duiven, P.; Boon, J.P.; Koeman, J.H. General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.

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Hyper- and hypothyroidism in pigeons fed DDT: An explanation for the ‘thin eggshell phenomenon’

Cited by 49 publications

References 12 publications

Contaminant effects on the teleost fish thyroid

Contaminant effects on the teleost fish thyroid

Animal Biomarkers as Pollution Indicators

Toxic and biochemical effects of 3,3′,4,4′-tetrachlorobiphenyl (CB-77) and clophen A50 on eider duckling (Somateria mollissima) in a semi-field experiment

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