Abstract:Severe defects in cell size are a nearly universal feature of cancer cells. However, the underlying causes are unknown. A previous study suggested that a hyperactive mutant of yeast Ras (ras2G19V) that is analogous to the human Ras oncogene causes cell size defects, which could provide clues to how oncogenes influence cell size. However, the mechanisms by whichras2G19Vinfluences cell size are unknown. Here, we found thatras2G19Vinhibits a critical step in cell cycle entry, in which an early G1 phase cyclin ind… Show more
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