Hyperacute rejections of two consecutive renal allografts and early loss of the third transplant caused by non-HLA antibodies specific for endothelial cells

Sumitran-Karuppan, S; Tydén, G; Reinholt, Finn P.; Berg, Ulf; Möller, Erna

doi:10.1016/s0966-3274(97)80016-0

Cited by 118 publications

(77 citation statements)

References 15 publications

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“…Pretransplant antiendothelial cell antibodies have been associated with endothelial injury that can be manifested as early rejection episodes that usually lead to graft loss. [37][38][39][40] B2GPI could act as an antiendothelial cell antibody-related antigen. It is localized on the endothelial cell surfaces associated with lipids or membrane proteins as receptors.…”

Section: Discussionmentioning

confidence: 99%

Association of Early Kidney Allograft Failure with Preformed IgA Antibodies to β 2-Glycoprotein I

Morales

Martínez-Flores²,

Serrano

et al. 2015

Journal of the American Society of Nephrology

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Section: Discussionmentioning

confidence: 99%

Association of Early Kidney Allograft Failure with Preformed IgA Antibodies to β 2-Glycoprotein I

Morales

Martínez-Flores²,

Serrano

et al. 2015

Journal of the American Society of Nephrology

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“…Mounting evidence suggests that antibodies targeting vascular endothelial cell are involved in allograft rejection (9,10,12,13). However, the vascular endothelial cell antigen system is a minor histocompatibility system, genetically linked to HLA antigens (1).…”

Section: Discussionmentioning

confidence: 99%

“…Following transplantation, the presence of antibodies to non-HLA antigens has been reported to be a target for transplant rejection (9,10). Opelz reported that an analysis of the clinical outcomes of 4084 HLAidentical sibling transplantations, 10 years graft survival was 72.4% for patients without anti-HLA antibodies compared with 63.3% for patients with 1%-50% panel reactive antibodies (PRA), and 55.5% for patients with PRA )50%.…”

Section: Introductionmentioning

confidence: 99%

Pre-transplant serum concentrations of anti-endothelial cell antibody in panel reactive antibody negative renal recipients and its impact on acute rejection

Han

Lü²,

Jin³

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Background: Endothelial cell antigens are important targets in acute rejection (AR). Our goal was to measure the serum concentrations of pre-transplant antiendothelial cell antibody (AECA) in panel reactive antibody (PRA) negative recipients and its impact on AR within 6 months following renal transplantation. Methods: We retrospectively examined pre-transplant sera from 392 patients using cellular enzyme linked immunosorbent assay (ELISA) with substrate from a permanent endothelial cell line EAhy926. Equal volumes of serum from 40 healthy volunteers were mixed and used as the negative control. Results: The positive rate of AECA was 15.8%. There were no significant differences with respect to age, gender, original disease, dialysis history, immune suppressive regimen, cytomegalovirus (CMV) antigen positive rate, complement dependent cytotoxicity (CDC) level and soluble CD30 (sCD30) levels between the AECA positive group and AECA negative group. AR rate in the AECA positive group was higher than that in the AECA negative group (35.5% vs. 22.4%, ps0.023). The AECA positive patients had significantly higher rates of acute grade II T-cell mediated rejection (TMR) and acute antibody mediated rejection (AMR) compared with AECA negative patients. The concentrations of sCD30, and AECA were independent risk factors for AR within 6 months; the odds ratios were 7.005 and 2.469, respectively. Conclusions: Positive AECA was an independent risk factor for AR and appeared to correlate with relatively severe rejection subtypes. Clin Chem Lab Med 2009;47:1265-9.

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“…Efforts to use cross-reactive antigen groups (CREGS) have yielded minimum benefit (although improvement in CREG-matched transplants for African Americans have been reported) (1063)(1064)(1065). Non-HLA antigens, such as endothelial specific antigens, may also play a role in antibody-mediated rejection (1066).…”

Section: The Evaluation Of Renal Transplant Candidates: Clinical Pracmentioning

confidence: 99%

The Evaluation of the Renal Transplant Candidates: Clinical Practice Guidelines

2001

American Journal of Transplantation

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Hyperacute rejections of two consecutive renal allografts and early loss of the third transplant caused by non-HLA antibodies specific for endothelial cells

Cited by 118 publications

References 15 publications

Association of Early Kidney Allograft Failure with Preformed IgA Antibodies to β 2-Glycoprotein I

Association of Early Kidney Allograft Failure with Preformed IgA Antibodies to β 2-Glycoprotein I

Pre-transplant serum concentrations of anti-endothelial cell antibody in panel reactive antibody negative renal recipients and its impact on acute rejection

The Evaluation of the Renal Transplant Candidates: Clinical Practice Guidelines

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