Hyperbaric hyperoxia alters innate immune functional properties during NASA Extreme Environment Mission Operation (NEEMO)

Strewe, Claudia; Crucian, Brian; Sams, Clarence F.; Feuerecker, Benedikt; Stowe, Raymond P.; Choukèr, Alexander; Feuerecker, Matthias

doi:10.1016/j.bbi.2015.06.017

Cited by 16 publications

(11 citation statements)

References 32 publications

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“…In general, these systems constitute an aggregate of adaptive reactions involving all the functional systems and tissues of the organism. The principle effects of spaceflight factors include: Energy imbalance - when the body’s energy expenditure is not reimbursed by the incoming food, which imposes serious consequences for many physical processes 2 – 4 Negative balance of water and calcium 5 , 6 , although sodium balance is possibly positive 7 , 8 Demineralization and modification of bone structure 9 Ineffective thermal regulation 10 , 11 Shifts in biorhythms of heat production, hormonal secretion, and cardiac function 12 – 14 Re-structuring of the vasomotion control 15 and dysfunction of the vascular endothelium 16 Muscular hypotrophy 17 – 19 , loss in tone and deterioration of force-velocity properties 20 , 21 Functional differentiation of the sensory systems and consequent disorders in motor control 21 , 22 Modification of pulmonary volumes, respiration biomechanics and chemoreceptor regulation 23 , 24 Immune system dysfunction 25 – 27 Spaceflight anemia 28 . …”

Section: Introductionmentioning

confidence: 99%

Protein expression changes caused by spaceflight as measured for 18 Russian cosmonauts

Ларина

Percy

Yang

et al. 2017

Sci Rep

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The effects of spaceflight on human physiology is an increasingly studied field, yet the molecular mechanisms driving physiological changes remain unknown. With that in mind, this study was performed to obtain a deeper understanding of changes to the human proteome during space travel, by quantitating a panel of 125 proteins in the blood plasma of 18 Russian cosmonauts who had conducted long-duration missions to the International Space Station. The panel of labeled prototypic tryptic peptides from these proteins covered a concentration range of more than 5 orders of magnitude in human plasma. Quantitation was achieved by a well-established and highly-regarded targeted mass spectrometry approach involving multiple reaction monitoring in conjunction with stable isotope-labeled standards. Linear discriminant function analysis of the quantitative results revealed three distinct groups of proteins: 1) proteins with post-flight protein concentrations remaining stable, 2) proteins whose concentrations recovered slowly, or 3) proteins whose concentrations recovered rapidly to their pre-flight levels. Using a systems biology approach, nearly all of the reacting proteins could be linked to pathways that regulate the activities of proteases, natural immunity, lipid metabolism, coagulation cascades, or extracellular matrix metabolism.

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Section: Introductionmentioning

confidence: 99%

Protein expression changes caused by spaceflight as measured for 18 Russian cosmonauts

Ларина

Percy

Yang

et al. 2017

Sci Rep

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“…An increased expression of the adhesion molecule CD11b and shedding of CD62L on PMNLs were also detected. Moreover, PMNLs related H 2 O 2 production exhibited an increased sensitivity to adenosine (50). These results illustrate an inflammatory high alert state with increased sensitivity towards possible stimuli.…”

Section: Short-term Confinement In Underwater Habitats: Bridging Sciementioning

confidence: 66%

“…NASA Extreme Environment Mission Operations (NEEMO) trains astronauts in this unique underwater setting during 10 -14 space analog missions. Astronauts are subjected to isolation and confinement in an extreme environment based station, daily 5-to 9-h dives simulating extra vehicular activity (EVA), and circadian-rhythm misalignment due to a lack of natural synchronizers (10,50).…”

Section: Short-term Confinement In Underwater Habitats: Bridging Sciementioning

confidence: 99%

Effects of isolation and confinement on humans-implications for manned space explorations

Pagel¹,

Choukèr²

2016

Journal of Applied Physiology

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113

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Human psychology and physiology are significantly altered by isolation and confinement. In light of planned exploration class interplanetary missions, the related adverse effects on the human body need to be explored and defined as they have a large impact on a mission's success. Terrestrial space analogs offer an excellent controlled environment to study some of these stressors during a space mission in isolation without the complex environment of the International Space Station. Participants subjected to these space analog conditions can encounter typical symptoms ranging from neurocognitive changes, fatigue, misaligned circadian rhythm, sleep disorders, altered stress hormone levels, and immune modulatory changes. This review focuses on both the psychological and the physiological responses observed in participants of long-duration spaceflight analog studies, such as Mars500 or Antarctic winter-over. They provide important insight into similarities and differences encountered in each simulated setting. The identification of adverse effects from confinement allows not only the crew to better prepare for but also to design feasible countermeasures that will help support space travelers during exploration class missions in the future.

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“…This suggests that interactions between some Clostridium clusters and Bacteroides species may preserve intestinal homeostasis and immunity. Under hyperbaric conditions, granulocytes and lymphocytes were reported to increase in number, and they also exhibited greater activity and adhesive capacity [16]. This may be one of the reasons why immunological changes involving Clostridium cluster IV, Clostridium subcluster XIVa, and Bacteroides species were seen in the fecal microbiota in our study.…”

mentioning

confidence: 58%

Effects of hyperbaric conditions on fecal microbiota

Oya¹,

Tadano²,

Takihata³

et al. 2019

Bioscience of Microbiota, Food and Health

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We aimed to determine whether the composition of the fecal microbiota changes under hyperbaric conditions. In this study, we collected fecal samples from 6 healthy divers at three points during deep diving training (before, 2.1 MPa, end). The frequency of Clostridium cluster XVIII tended to be increased after compression. The frequencies of Clostridium cluster IV and subcluster XIVa were inversely correlated with that of Bacteroides. The compositional changes in the fecal microbiota exhibited interindividual variability. These findings suggest that hyperbaric conditions affect the fecal microbiota.

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Hyperbaric hyperoxia alters innate immune functional properties during NASA Extreme Environment Mission Operation (NEEMO)

Cited by 16 publications

References 32 publications

Protein expression changes caused by spaceflight as measured for 18 Russian cosmonauts

Protein expression changes caused by spaceflight as measured for 18 Russian cosmonauts

Effects of isolation and confinement on humans-implications for manned space explorations

Effects of hyperbaric conditions on fecal microbiota

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