Hyperbaric oxygen and photodynamic therapy in the treatment of advanced carcinoma of the cardia and the esophagus

Maier, Andrea B.; Anegg, Udo; Fell, B.; Rehak, Peter; Ratzenhofer, B; Tomaselli, Florian; Sankin, Oliver; Pintér, H; Smolle‐Jüttner, Freyja Maria; Friehs, G

doi:10.1002/(sici)1096-9101(2000)26:3<308::aid-lsm9>3.0.co;2-b

Cited by 68 publications

(50 citation statements)

References 16 publications

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“…HBO is considered a safe clinical treatment and has been used for ischemia, acute carbon monoxide poisoning, nonhealing wounds, and late radiation injury 9. As an effective approach in elevating oxygen content, HBO has already been combined with radiotherapy and photodynamic therapy for hypoxic solid tumor treatment 10. However, HBO is seldom combined with chemotherapy, especially drugs which execute antitumor effect through reactive oxygen species (ROS), such as DOX, because HBO may exasperate the side effects of these drugs.…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen Potentiates Doxil Antitumor Efficacy by Promoting Tumor Penetration and Sensitizing Cancer Cells

Zhu

Huang

et al. 2018

Advanced Science

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Hypoxia is a fundamental hallmark of solid tumors and helps contribute to chemotherapy resistance. Hyperbaric oxygen (HBO) therapy can overcome tumor hypoxia and promote chemotherapy antitumor efficacy; however, the simultaneous administration of some conventional chemotherapies, including doxorubicin (DOX), with HBO is considered an absolute contraindication. Here, DOX‐loaded liposome (Doxil) is coadministered with HBO to assess the safety and efficacy of this combination treatment. By overcoming tumor hypoxia, HBO not only improves Doxil tumor penetration by decreasing the collagen deposition but also sensitizes tumor cells to Doxil. As a result, the combination treatment synergistically inhibits H22 tumor growth, with a tumor inhibition rate of 91.5%. The combination of HBO with Doxil shows neither extra side effects nor promotion of tumor metastasis. These results collectively reveal that the combination of HBO with Doxil is an effective and safe treatment modality. As both HBO and Doxil are routinely used, their combination could quickly translate to clinical trials for patients with hypoxic solid tumors.

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Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen Potentiates Doxil Antitumor Efficacy by Promoting Tumor Penetration and Sensitizing Cancer Cells

Zhu

Huang

et al. 2018

Advanced Science

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“…Meta-analysis was not possible due to heterogeneity between the trials. All trials reported morbidity results, seven reported on mortality [113][114][115][116][117][118][119] and four reported on QoL outcomes. [115][116][117][118] Only two of the studies reported resource use, both in terms of days of hospitalisation.…”

Section: Results Of Effectiveness (Palliative Intent)mentioning

confidence: 99%

“…115,116 Dysphagia scores were significantly reduced in the PDT-plus-HBO group in only one trial. 116 Stenosis length decreased overall, between 5 and 6 mm, but these changes were not significantly different between groups.…”

Section: Morbiditymentioning

confidence: 96%

“…[107][108][109][110][111][112][113][114][115][116][117][118][119] Three studies were available only as abstracts, 107,110,111 the rest were published as full papers. In a small number of trials, the presented data did not appear to entirely support the authors' conclusions; this has been indicated in the data extraction tables.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…110 Eight studies reported on palliative PDT treatments for oesophageal cancer, four RCTs 112-114,119 and four non-randomised comparative trials. [115][116][117][118] Participants in six studies were diagnosed with advanced oesophageal cancer, and overall most trials included only patients who were not eligible for resection due to anatomical restrictions, poor health or refusal. Comparators in these trials included chemotherapy, radiotherapy, neodymium-doped yttrium aluminium garnet (Nd:YAG) laser or PDT.…”

Section: Study Characteristicsmentioning

confidence: 99%

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A systematic review of photodynamic therapy in the treatment of pre-cancerous skin conditions, Barrett’s oesophagus and cancers of the biliary tract, brain, head and neck, lung, oesophagus and skin

Fayter

Corbett²,

Heirs³

et al. 2010

Health Technol Assess

128

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address. Paying by credit cardYou can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume. How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeT he Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of project...

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In vivo determination of tumor optical parameters in esophageal carcinoma

et al. 2000

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Hyperbaric oxygen and photodynamic therapy in the treatment of advanced carcinoma of the cardia and the esophagus

Cited by 68 publications

References 16 publications

Hyperbaric Oxygen Potentiates Doxil Antitumor Efficacy by Promoting Tumor Penetration and Sensitizing Cancer Cells

Hyperbaric Oxygen Potentiates Doxil Antitumor Efficacy by Promoting Tumor Penetration and Sensitizing Cancer Cells

A systematic review of photodynamic therapy in the treatment of pre-cancerous skin conditions, Barrett’s oesophagus and cancers of the biliary tract, brain, head and neck, lung, oesophagus and skin

In vivo determination of tumor optical parameters in esophageal carcinoma

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