Hyperbaric oxygen and steroid therapy for idiopathic sudden sensorineural hearing loss

Fujimura, Takeyuki; Suzuki, Hideaki; Shiomori, Teruo; Udaka, Tsuyoshi; Mori, Takanori

doi:10.1007/s00405-007-0272-6

Cited by 73 publications

(69 citation statements)

References 27 publications

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“…Combination of HBO and steroid therapy compared to steroid therapy alone significantly improved hearing outcome [25] . The addition of HBO therapy to primaryconventional therapy improved the results when started early after the onset of SSNHL and was more successful in patients with a hearing loss greater than 60 dB [15] . A recent study compared four primary therapy protocols for patients with SSNHL: oral steroid therapy, intratympanic steroid therapy, HBO therapy, and HBO therapy combined with oral steroid therapy [19] .…”

Section: Discussionmentioning

confidence: 99%

“…[11] It was found that perilymphatic oxygen tension decreased in patients with SSNHL, while under hyperbaric conditions, oxygen tension in the perilymphatic fluid increased by 450% [12,13] . These days, HBO therapy is used as primary or as salvage therapy for sudden haring loss [14][15][16] . However, the results of salvage HBO therapy for SSNHL vary among studies, and its efficacy is still unclear.…”

Section: Introductionmentioning

confidence: 99%

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Hyperbaric Oxygen Therapy as Salvage Therapy for Sudden Sensorineural Hearing Loss

Ajduk¹,

Ries²,

Trotić³

et al. 2017

Int Adv Otol

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OBJECTIVE:To measure the effect of hyperbaric oxygen (HBO) therapy as salvage therapy after the failure of steroid therapy for sudden sensorineural hearing loss (SSNHL). MATERIALS and METHODS:Ninety-three patients with SSNHL were unsuccessfully treated with systemic steroid therapy. Following steroid therapy, 43 patients received additional HBO therapy while 50 did not. Hearing levels at 0.25, 0.5, 1, 2, 4, and 8 kHz before and after therapy were measured. RESULTS:A significant difference in hearing thresholds after HBO therapy was found at all frequencies in patients with a hearing loss of >61 dB. The group of patients with a hearing threshold of ≤60 dB had a significant improvement only at 250 and 500 Hz, while group of patients without additional therapy control group showed no hearing improvement. CONCLUSION:Hyperbaric oxygen therapy therapy as salvage therapy for SSNHL showed some benefits in hearing improvement. Better results could be expected in patients with severe hearing loss, while in patients with mild-or-moderate hearing loss, recovery should be expected only at low frequencies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy as Salvage Therapy for Sudden Sensorineural Hearing Loss

Ajduk¹,

Ries²,

Trotić³

et al. 2017

Int Adv Otol

View full text Add to dashboard Cite

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“…173,177,235,236,[238][239][240][241] Patients with moderate to severe hearing loss benefit more from HBOT than those with mild hearing loss (moderate hearing loss cutoff was usually at 60 dB). 168,[170][171][172][242][243][244] Results of studies detailing effectiveness of HBOT depend on the choice of outcome measures. 166 fees in academic institutions are approximately $600 to $700 per session, including both technical and professional fees.…”

Section: Supporting Textmentioning

confidence: 99%

Clinical Practice Guideline

Stachler

Chandrasekhar

Archer

et al. 2012

Otolaryngol.--head neck surg.

784

361

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Objective. Sudden hearing loss (SHL) is a frightening symptom that often prompts an urgent or emergent visit to a physician. This guideline provides evidence-based recommendations for the diagnosis, management, and follow-up of patients who present with SHL. The guideline primarily focuses on sudden sensorineural hearing loss (SSNHL) in adult patients (aged 18 and older). Prompt recognition and management of SSNHL may improve hearing recovery and patient quality of life (QOL). Sudden sensorineural hearing loss affects 5 to 20 per 100,000 population, with about 4000 new cases per year in the United States. This guideline is intended for all clinicians who diagnose or manage adult patients who present with SHL.Purpose. The purpose of this guideline is to provide clinicians with evidence-based recommendations in evaluating patients with SHL, with particular emphasis on managing SSNHL. The panel recognized that patients enter the health care system with SHL as a nonspecific, primary complaint. Therefore, the initial recommendations of the guideline deal with efficiently distinguishing SSNHL from other causes of SHL at the time of presentation. By focusing on opportunities for quality improvement, the guideline should improve diagnostic accuracy, facilitate prompt intervention, decrease variations in management, reduce unnecessary tests and imaging procedures, and improve hearing and rehabilitative outcomes for affected patients.Results. The panel made strong recommendations that clinicians should (1) distinguish sensorineural hearing loss from conductive hearing loss in a patient presenting with SHL; (2) educate patients with idiopathic sudden sensorineural hearing loss (ISSNHL) about the natural history of the condition, the benefits and risks of medical interventions, and the limitations of existing evidence regarding efficacy; and (3) counsel patients with incomplete recovery of hearing about the possible benefits of amplification and hearing-assistive technology and other supportive measures. The panel made recommendations that clinicians should (1) assess patients with presumptive SSNHL for bilateral SHL, recurrent episodes of SHL, or focal neurologic findings; (2) diagnose presumptive ISSNHL if audiometry confirms a 30-dB hearing loss at 3 consecutive frequencies and an underlying condition cannot be identified by history and physical examination; (3) evaluate patients with ISSNHL for retrocochlear pathology by obtaining magnetic resonance imaging, auditory brainstem response, or audiometric follow-up; (4) offer intratympanic steroid perfusion when patients have incomplete recovery from ISSNHL after failure of initial management; and (5) obtain follow-up audiometric evaluation within 6 months of diagnosis for patients with ISSNHL. The panel offered as options that clinicians may offer (1) corticosteroids as initial therapy to patients with ISSNHL and (2) hyperbaric oxygen therapy within 3 months of diagnosis of ISSNHL. The panel made a recommendation against clinicians routinely prescribing antivirals,...

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“…Although the mechanism of HBO therapy in inner ear has not been still fully understood, today, it is an important adjuvant therapy and being increasingly used in a variety of disorders, such as severe anaemia, decompressive diseases, arterial gas embolism, carbon monoxide poisoning, stimulant of wound healing on refractory wounds, gas gangrene, radiation injury, necrotizing infections, and chronic osteomyelitis [7][8][9]. It has been also used in the management of acute ischemia-related disorders like acute sensorineural hearing loss such as sudden deafness, and acute noise trauma [8,[10][11][12][13][14][15]. But to the best of our knowledge, no study to date have investigated the possible protective effect of HBO against to ototoxic effect of aminoglycoside.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Hyperbaric Oxygen Therapy Against Streptomycin Ototoxicity

Bakır¹,

Özbay²,

Kınış³

et al. 2014

Ann Clin Anal Med

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ÖzetAmaç: Hiperbarik oksijen (HBO), önemli antioksidan aktivitesi nedeniyle çe-şitli hastalıkların tedavisinde giderek artan oranda kullanılmakta olan bir adjuvan tedavi metodudur. Bu deneysel çalışmada streptomisine bağlı ototoksisitenin önlenmesinde HBO tedavisinin etkinliğinin araştırılması amaçlan-mıştır. Gereç ve Yöntem: Yirmi sekiz adet erişkin Wistar albino rat randomize olarak 4 gruba ayrıldı: Kontrol (n=7), streptomisin (n=7), HBO (n=7) ve streptomisin+HBO (n=7). HBO uygulanan sıçanlar basınçlı tank içine yerleş-tirildi ve yedi günlük bir süre içinde günde 60 dakika boyunca 2.5 mutlak atmosfer basınçta % 100 oksijen almaları sağlandı. Sıçanların işitme düzeyle-ri HBO uygulaması başlamadan önce ve son gün distortion product otoakustik emisyon (DPOAE) ile test edildi. 7. günde son DPOAE ölçümleri takiben genel anestezi altında tüm gruplardaki hayvanlar sakrifiye edildi. DPOAE amplitüdlerindeki farklılıklar belirlenerek işitme sonuçları istatistiksel olarak analiz edildi. Ayrıca, her sıçanın kokleası hematoksilen ve eozin (H&E) ile histopatolojik olarak ışık mikroskobu altında değerlendirildi. Bulgular: Kontrol ve HBO grubunda histopatolojik değerlendirmede koklear tüylü hücrelerin ço-ğunlukla korunduğu gözlendi. DPOAE sonuçlarında ise tedavi öncesi ve sonrası arasında anlamlı bir fark saptanmadı (p>0.05). Öte yandan, streptomisin ve streptomisin+HBO uygulanan sıçanlarda hem tüylü hücrelerde hemde işitme fonksiyonlarında kayıp saptandı (p<0.05). Streptomisin+HBO grubunun DPgram sonuçları, streptomisin grubunun DPgram sonuçları ile karşılaş-tırıldığında anlamlılık yoktu (p>0.05). Tartışma: Antioksidan özellikli HBO'nun koklear tüylü hücreler üzerinde zararlı bir etkisi gözlenmemiştir. Öte yandan, sıçanlarda oluşturulan streptomisine bağlı koklear hasara karşı da koruyucu bir etkisi olmadığı sonucuna varılmıştır. Anahtar KelimelerAminoglikozid; Streptomisin; Ototoksisite; İşitme Kaybı; Hiperbarik Oksijen Abstract Aim: Hyperbaric oxygen (HBO) is an important adjuvant therapy and being increasingly used in the treatment of various disorders because of having an important antioxidant activity. This experimental study was designed to determine the possible protective effect of HBO therapy on streptomycininduced ototoxicity. Material and Method: Twenty-eight adult Wistar albino rats were divided into four groups: Streptomycin (n=7), saline (n=7), HBO (n=7), and streptomycin plus HBO (n=7). The HBO administered rats were placed into a large pressure chamber and received 100% oxygene at 2.5 atmosphere absolute for 60 minutes per day in a period of seven days. Rats were tested with DPOAE (Distortion Product Otoacoustic Emissions) in the beginning and the end of study. The animals in all groups were sacrificed under general anesthesia on the seventh day. Biopsy specimens from inner ear were stored for histopathologic examination with hematoxylin and eosin (H&E) under light microscopy. Results: Outer hair cells shown by light microscopic images were mostly preserved in control and HBO group. DPOAE measurements reveale...

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Hyperbaric oxygen and steroid therapy for idiopathic sudden sensorineural hearing loss

Cited by 73 publications

References 27 publications

Hyperbaric Oxygen Therapy as Salvage Therapy for Sudden Sensorineural Hearing Loss

Hyperbaric Oxygen Therapy as Salvage Therapy for Sudden Sensorineural Hearing Loss

Clinical Practice Guideline

The Effects of Hyperbaric Oxygen Therapy Against Streptomycin Ototoxicity

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