Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of metastatic lung tumors in a rat model

Petré, P.; Baciewicz, Frank A.; Ţigan, Ştefan; Spears, J. Richard

doi:10.1067/mtc.2003.90

Cited by 51 publications

(43 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Within an oncological framework, we have demonstrated a relationship between liver regeneration and oxygen consumption. Improved liver regeneration with HBO therapy has been ascribed to an increase in the delivery of oxygen to the liver [49], and increased oxygen levels in liver tissue may give rise to an increase in the number of vessels and the mitotic rate in the tumor, thereby promoting the effectiveness of chemotherapy [47, 50].…”

Section: Discussionmentioning

confidence: 99%

Can hyperbaric oxygenation decrease doxorubicin hepatotoxicity and improve regeneration in the injured liver?

Fırat

Kirdok

Makay

et al. 2009

J Hepatobiliary Pancreat Surg

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Can hyperbaric oxygenation decrease doxorubicin hepatotoxicity and improve regeneration in the injured liver?

Fırat

Kirdok

Makay

et al. 2009

J Hepatobiliary Pancreat Surg

View full text Add to dashboard Cite

show abstract

“…HBO 2 T enhances tumor-cell production of reactive oxygen species which contributes to the synergistic effects of HBO 2 T as an adjuvant treatment to standard care. Indeed, HBO 2 T enhances the efficacy of both radiation and chemotherapy in animal models [53], [54], [55], [56], [57].…”

Section: Introductionmentioning

confidence: 99%

The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer

et al. 2013

View full text Add to dashboard Cite

IntroductionAbnormal cancer metabolism creates a glycolytic-dependency which can be exploited by lowering glucose availability to the tumor. The ketogenic diet (KD) is a low carbohydrate, high fat diet which decreases blood glucose and elevates blood ketones and has been shown to slow cancer progression in animals and humans. Abnormal tumor vasculature creates hypoxic pockets which promote cancer progression and further increase the glycolytic-dependency of cancers. Hyperbaric oxygen therapy (HBO2T) saturates tumors with oxygen, reversing the cancer promoting effects of tumor hypoxia. Since these non-toxic therapies exploit overlapping metabolic deficiencies of cancer, we tested their combined effects on cancer progression in a natural model of metastatic disease.MethodsWe used the firefly luciferase-tagged VM-M3 mouse model of metastatic cancer to compare tumor progression and survival in mice fed standard or KD ad libitum with or without HBO2T (2.5 ATM absolute, 90 min, 3x/week). Tumor growth was monitored by in vivo bioluminescent imaging.ResultsKD alone significantly decreased blood glucose, slowed tumor growth, and increased mean survival time by 56.7% in mice with systemic metastatic cancer. While HBO2T alone did not influence cancer progression, combining the KD with HBO2T elicited a significant decrease in blood glucose, tumor growth rate, and 77.9% increase in mean survival time compared to controls.ConclusionsKD and HBO2T produce significant anti-cancer effects when combined in a natural model of systemic metastatic cancer. Our evidence suggests that these therapies should be further investigated as potential non-toxic treatments or adjuvant therapies to standard care for patients with systemic metastatic disease.

show abstract

“…Because of this, HBO has previously been used to enhance the pO 2 in hypoxic tumor tissue, to potentiate the effect of radio- and photo-therapy in both clinical and preclinical trials and also the effect of some forms of chemotherapy like doxorubicin, alkylating agents and 5FU [13-16]. This effect has been ascribed as increased cytotoxicity of the tumor cells to the chemotherapeutic drug in vitro [16,17] and enhanced neovascularisation in vivo [18]. However, recent studies have shown reduced vascularisation after HBO treatment in vivo [19-21].…”

Section: Introductionmentioning

confidence: 99%

Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma

et al. 2009

View full text Add to dashboard Cite

BackgroundHypoxia is associated with increased resistance to chemo- and radiation-therapy. Hyperoxic treatment (hyperbaric oxygen) has previously been shown to potentiate the effect of some forms of chemotherapy, and this has been ascribed to enhanced cytotoxicity or neovascularisation. The aim of this study was to elucidate whether hyperoxia also enhances any actual uptake of 5FU (5-fluorouracil) into the tumor tissue and if this can be explained by changes in the interstitium and extracellular matrix.MethodsOne group of tumor bearing rats was exposed to repeated hyperbaric oxygen (HBO) treatment (2 bar, pO2 = 2 bar, 4 exposures à 90 min), whereas one group was exposed to one single identical HBO treatment. Animals housed under normal atmosphere (1 bar, pO2 = 0.2 bar) served as controls. Three doses of 5FU were tested for dose response. Uptake of [3H]-5FU in the tumor was assessed, with special reference to factors that might have contributed, such as interstitial fluid pressure (Pif), collagen content, oxygen stress (measured as malondialdehyd levels), lymphatics and transcapillary transport in the tumors.ResultsThe uptake of the cytostatic agent increases immediately after a single HBO treatment (more than 50%), but not 24 hours after the last repeated HBO treatment. Thus, the uptake is most likely related to the transient increase in oxygenation in the tumor tissue. Factors like tumor Pif and collagen content, which decreased significantly in the tumor interstitium after repeated HBO treatment, was without effect on the drug uptake.ConclusionWe showed that hyperoxia increases the uptake of [3H]-5FU in DMBA-induced mammary tumors per se, independently of changes in Pif, oxygen stress, collagen fibril density, or transendothelial transport alone. The mechanism by which such an uptake occur is still not elucidated, but it is clearly stimulated by elevated pO2.

show abstract

Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of metastatic lung tumors in a rat model

Abstract: Hyperbaric oxygen enhanced the chemotherapeutic effect of doxorubicin both in cell culture and in the rat model. Aqueous oxygen infusion can be used to oxygenate mixed venous blood at levels similar to those obtained with the use of a hyperbaric chamber.

Cited by 51 publications

References 17 publications

Can hyperbaric oxygenation decrease doxorubicin hepatotoxicity and improve regeneration in the injured liver?

Can hyperbaric oxygenation decrease doxorubicin hepatotoxicity and improve regeneration in the injured liver?

The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer

Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma

Contact Info

Product

Resources

About