Hyperbaric oxygen therapy ameliorates pathophysiology of 3xTg-AD mouse model by attenuating neuroinflammation

Shapira, Ronit; Solomon, Beka; Efrati, Shai; Frenkel, Dan; Ashery, Uri

doi:10.1016/j.neurobiolaging.2017.10.007

Cited by 63 publications

(49 citation statements)

References 88 publications

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“…As we can visualise plaques from around the age the J20-hAPP mice, these observations could be related to early Aβ deposition. In terms of corroboration and translatability of these findings, it has previously been demonstrated that hyperbaric oxygen therapy reduces neuroinflammation in the 3xTg AD mouse model 16 . Here, we present findings that normobaric 11 hyperoxia can enhance cerebral haemodynamics and therefore may potentially be able to clear Aβ from the brain.…”

Section: Discussionmentioning

confidence: 55%

Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer’s Disease

Shabir

Sharp

Rebollar

et al. 2019

Preprint

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AbstractEarly impairments to neurovascular coupling have been proposed to be a key pathogenic factor in the onset and progression of Alzheimer’s disease (AD). Studies have shown impaired neurovascular function in several mouse models of AD, including the J20-hAPP mouse. In this study, we aimed to investigate early neurovascular changes using wild-type (WT) controls and J20-hAPP mice at 6-9 months of age, by measuring cerebral haemodynamics and neural activity to physiological sensory stimulations. A thinned cranial window was prepared to allow access to cortical vasculature and imaged using 2D-optical imaging spectroscopy (2D-OIS). After chronic imaging sessions where the skull was intact, a terminal acute imaging session was performed where an electrode was inserted into the brain to record simultaneous neural activity. We found that cerebral haemodynamic changes were significantly enhanced in J20-hAPP mice compared with controls in response to physiological stimulations, potentially due to the significantly higher neural activity (hyperexcitability) seen in the J20-hAPP mice. Thus, neurovascular coupling remained preserved under a chronic imaging preparation. Further, under hyperoxia, the baseline blood volume and saturation of all vascular compartments in the brains of J20-hAPP mice were substantially enhanced compared to WT controls, but this effect disappeared under normoxic conditions. This study highlights novel findings not previously seen in the J20-hAPP mouse model, and may point towards a potential therapeutic strategy by driving an increased baseline blood flow to the brain, thereby potentially enhancing the clearance of beta-amyloid.

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Section: Discussionmentioning

confidence: 55%

Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer’s Disease

Shabir

Sharp

Rebollar

et al. 2019

Preprint

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“…Moreover, a morphological examination showed that HBOT enhances microglial process extension and increases the number of sprouting microglia around the plaques, which could indicate a change in the microglia's activation state and function. These findings emerged in parallel to a reduction in hypoxia levels and in the amount of amyloid plaques, and improvement in cognitive-and anxiety-like-related behaviors [28].…”

Section: The Impact Of Hbot On Neuroinflammationmentioning

confidence: 81%

“…These plaques may incur microgliosis, in which activated microglia surround the plaques and secrete proinflammatory cytokines [85][86][87]. Shapira et al [28], studied the influence of HBOT on an AD mouse model and found less microglia around the amyloid plaques after the treatment, along with less proinflammatory cytokines such as TNF-α, as shown by immunofluorescence staining in the hippocampus. Those researchers suggested that the reduction in the amount of cytokines might be due to the reduced amount of microglia.…”

Section: The Impact Of Hbot On Neuroinflammationmentioning

confidence: 99%

“…For instance, treatment of diabetic wounds typically lasts for 30-40 days, at pressures of 2.0-2.4 ATA [25], whereas for stroke, in several studies the treatment that was used lasted for two months, with the subject being treated five days a week at a pressure of two ATA [26,27]. By providing a high-pressure oxygen-rich environment, HBOT increases the concentration of dissolved oxygen in the blood plasma and arterial oxygen pressure, which in turn might assist in supplying oxygen to hypoxic tissue [28,29].…”

Section: Hbotmentioning

confidence: 99%

“…For example, in TBI, HBOT was found to improve CBF [33], restore impaired brain metabolism, as shown by increased cerebral adenosine triphosphate (ATP)-expression levels in a TBI rat model [34], decrease secondary cell death and neuroinflammation in a TBI rat model [35], and improve neuroplasticity [36]. In addition, improvement in memory and cognitive functions was found in treated subjects that suffered from chronic cognitive impairments [37] and in a treated AD mouse model [28]. Recently, HBOT has also been assessed for several NDDs, such as autism [6].…”

Section: Hbotmentioning

confidence: 99%

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Molecular and Therapeutic Aspects of Hyperbaric Oxygen Therapy in Neurological Conditions

Fischer

Barak

2020

Biomolecules

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In hyperbaric oxygen therapy (HBOT), the subject is placed in a chamber containing 100% oxygen gas at a pressure of more than one atmosphere absolute. This treatment is used to hasten tissue recovery and improve its physiological aspects, by providing an increased supply of oxygen to the damaged tissue. In this review, we discuss the consequences of hypoxia, as well as the molecular and physiological processes that occur in subjects exposed to HBOT. We discuss the efficacy of HBOT in treating neurological conditions and neurodevelopmental disorders in both humans and animal models. We summarize by discussing the challenges in this field, and explore future directions that will allow the scientific community to better understand the molecular aspects and applications of HBOT for a wide variety of neurological conditions.

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Hyperbaric oxygen ameliorates cognitive impairment in patients with Alzheimer's disease and amnestic mild cognitive impairment

Chen

Zhang

Zhao

et al. 2020

A&D Transl Res & Clin Interv

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Introduction It has been reported that environmental factors such as hypoxia could contribute to the pathogenesis of Alzheimer's disease (AD). Therapeutics like hyperbaric oxygen treatment, which improves tissue oxygen supply and ameliorates hypoxic conditions in the brain, may be an alternative therapy for AD and amnestic mild cognitive impairment (aMCI). The present work aims to investigate the potential therapeutic effect of hyperbaric oxygen treatment for AD and aMCI. Methods We recruited 42 AD, 11 aMCI, and 30 control AD patients in this study. AD and aMCI patients were treated with 40 minutes of hyperbaric oxygen once a day for 20 days and assessed by neuropsychiatric assessments including Mini‐Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Activities of Daily Living (ADL) scale before and at 1‐, 3‐, and 6‐month follow‐up after treatment. Control AD patients who were not given hyperbaric oxygen treatment had similar clinical profile as hyperbaric oxygen treated AD. We examined 10 of the AD/aMCI patients with fluorodeoxyglucose positron emission tomography. Results In self‐comparison study, one course of hyperbaric oxygen treatment significantly improved the cognitive function assessed by MMSE and MoCA in AD patients after 1‐month follow‐up; such treatment also significantly improved MMSE score at 3‐month follow‐up and MoCA score at 1‐ and 3‐month follow‐up in aMCI patients. The ADL scale was significantly improved in AD patients after 1‐ and 3‐month follow‐up. Compared to the control AD patients, the MMSE and MoCA in hyperbaric oxygen treated AD patients were significantly improved after 1‐month follow‐up. Hyperbaric oxygen treatment also ameliorated the reduced brain glucose metabolism in some of the AD and aMCI patients. Conclusion Based on previous studies and our recent findings, we propose that hyperbaric oxygen treatment may be a promising alternative therapy for AD and aMCI.

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Hyperbaric oxygen therapy ameliorates pathophysiology of 3xTg-AD mouse model by attenuating neuroinflammation

Cited by 63 publications

References 88 publications

Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer’s Disease

Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer’s Disease

Molecular and Therapeutic Aspects of Hyperbaric Oxygen Therapy in Neurological Conditions

Hyperbaric oxygen ameliorates cognitive impairment in patients with Alzheimer's disease and amnestic mild cognitive impairment

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