Hyperbaric Oxygen Therapy and Utilization in Infectious Disease

Bennett, Megan; Kaide, Colin G.; Matheson, Elizabeth; Bari, Vase

doi:10.1007/s40138-018-0166-5

Cited by 4 publications

(2 citation statements)

References 54 publications

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“…Hyperbaric oxygen, which is an effective treatment for diabetic patients who have rhinocerebral or severe cutaneous mucormycosis [ 121 ], increases the partial pressure of oxygen and improves neutrophilic function. High oxygen concentrations also improve wound healing by releasing enhanced tissue growth factors [ 122 ]. However, such therapy has not been subjected to detailed study and so is not regularly recommended.…”

Section: Adjunctive Therapiesmentioning

confidence: 99%

Mucormycosis in Indian COVID-19 Patients: Insight into Its Patho-Genesis, Clinical Manifestation, and Management Strategies

et al. 2021

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Mucormycosis in patients who have COVID-19 or who are otherwise immunocompromised has become a global problem, causing significant morbidity and mortality. Infection is debilitating and fatal, leading to loss of organs and emotional trauma. Radiographic manifestations are not specific, but diagnosis can be made through microscopic examination of materials collected from necrotic lesions. Treatment requires multidisciplinary expertise, as the fungus enters through the eyes and nose and may even reach the brain. Use of the many antifungal drugs available is limited by considerations of resistance and toxicity, but nanoparticles can overcome such limitations by reducing toxicity and increasing bioavailability. The lipid formulation of amphotericin-B (liposomal Am-B) is the first-line treatment for mucormycosis in COVID-19 patients, but its high cost and low availability have prompted a shift toward surgery, so that surgical debridement to remove all necrotic lesions remains the hallmark of effective treatment of mucormycosis in COVID-19. This review highlights the pathogenesis, clinical manifestation, and management of mucormycosis in patients who have COVID-19.

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Section: Adjunctive Therapiesmentioning

confidence: 99%

Mucormycosis in Indian COVID-19 Patients: Insight into Its Patho-Genesis, Clinical Manifestation, and Management Strategies

et al. 2021

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“…Rhinocerebral mucormycosis also results in Meningitis which is a rare manifestation of this infection (27). The involvement of brain tissue leads to the formation of brain abscesses, especially in chronic cases (29). Brain abscess formation in such cases may be caused by some secondary bacterial infection (30).…”

Section: Types Of Mucormycosismentioning

confidence: 99%

Black Fungus Mutilating COVID-19 Pandemic in India: Facts and Immunological Perspectives

Mondal¹,

Gireeshwar²,

Lekha³

2022

ejb

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While the world is still struggling with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, an aggressive and rare fungal infection which is commonly ascribed as the black fungus has emerged as a new medical challenge in India. India had already experienced the devastating consequences of the COVID-19 and, being a rare "opportunistic" fungal infection, black fungus infection has severely complicated the post-COVID-19 recoveries. Together with the uncertain treatment modalities at the beginning of the pandemic, indiscriminate use of a plethora of medications has driven the surging cases of black fungus-associated complications. Moreover, low oxygen, high iron levels, and prolonged hospitalization with mechanical ventilators created a superlative condition for contracting black fungus infection. The disease mainly spreads through the respiratory tract and erodes facial structures. Since mucormycosis specifically attacks immunosuppressed patients, the disease started spreading rapidly, with an average mortality rate of 54 %. Common symptoms include blackening over the nose, blurred or double vision, breathing difficulties, chest pain and hemoptysis. Although not contagious, the outcome of the disease is often very frightful.If the infection disseminates systematically, the risk of affecting the vital organs such as the spleen and heart is substantially high. We have tried to provide an epidemiological overview of black fungus infection in India. We focused on drawing a comprehensive fact check of the current situation through an immunological perspective to better understand the infection as a major co-infection in patients affected by COVID-19 and its impact on India's fight against the COVID-19 pandemic.

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Evaluating the Recommended Indications of HBOT

Gupta,

Somasundaram

2023

Hyperbaric Oxygen Therapy: Principles and Applications

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Hyperbaric Oxygen Therapy and Utilization in Infectious Disease

Cited by 4 publications

References 54 publications

Mucormycosis in Indian COVID-19 Patients: Insight into Its Patho-Genesis, Clinical Manifestation, and Management Strategies

Mucormycosis in Indian COVID-19 Patients: Insight into Its Patho-Genesis, Clinical Manifestation, and Management Strategies

Black Fungus Mutilating COVID-19 Pandemic in India: Facts and Immunological Perspectives

Evaluating the Recommended Indications of HBOT

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