Hyperbaric oxygen therapy: Can it be a novel supportive therapy in COVID-19?

Senniappan, Kirubanand; Jeyabalan, Salome; Rangappa, Pradeep; Kanchi, Muralidhar

doi:10.4103/ija.ija_613_20

Cited by 19 publications

(9 citation statements)

References 21 publications

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“…Hyperbaric oxygen therapy (HBOT) is a method for delivering high-pressure oxygen (more than 1 ATA) to patients. In addition to its effect in overcoming the air-blood barrier of the lungs, HBOT has beneficial effects on reducing inflammation has therefore been considered as a potential treatment option in COVID-19 [206] , [207] , [208] . A study analyzed treatment with hyperbaric oxygen at 2 atmospheres for 90 minutes in 20 COVID-19 cases.…”

Section: Filgotinibmentioning

confidence: 99%

An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19)

Elahi

Karami

Heidary

et al. 2022

International Immunopharmacology

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Section: Filgotinibmentioning

confidence: 99%

An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19)

Elahi

Karami

Heidary

et al. 2022

International Immunopharmacology

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“…Although it is still being evaluated scientifically, positive results are arising for COVID-19 treatment, finding an attenuation of the innate immune system, and increasing hypoxia tolerance [ 148 ]. In every report, this therapy has been rated as a potential support in the relieving of cytokine storm [ 149 ]. Now that mechanical ventilation may be long lasting and, preferably, avoided, in a controlled trial, safety and efficacy of HBOT for COVID-19 patients was successfully evaluated [ 150 ].…”

Section: Translational and Potential Applications Of Hbotmentioning

confidence: 99%

A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities

et al. 2021

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Hyperbaric oxygen therapy (HBOT) consists of using of pure oxygen at increased pressure (in general, 2–3 atmospheres) leading to augmented oxygen levels in the blood (Hyperoxemia) and tissue (Hyperoxia). The increased pressure and oxygen bioavailability might be related to a plethora of applications, particularly in hypoxic regions, also exerting antimicrobial, immunomodulatory and angiogenic properties, among others. In this review, we will discuss in detail the physiological relevance of oxygen and the therapeutical basis of HBOT, collecting current indications and underlying mechanisms. Furthermore, potential areas of research will also be examined, including inflammatory and systemic maladies, COVID-19 and cancer. Finally, the adverse effects and contraindications associated with this therapy and future directions of research will be considered. Overall, we encourage further research in this field to extend the possible uses of this procedure. The inclusion of HBOT in future clinical research could be an additional support in the clinical management of multiple pathologies.

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“…Hyperbaric Oxygen Therapy (HBOT) works on every stage by elevating diffusion rate, diffusion distance, and solubility based on the principles of physics Dalton's law and Henry's law. 65 , 66 , 67 , 68 , 69 …”

Section: Surgical Intervention/managementmentioning

confidence: 99%

COVID-19 associated mucormycosis: Staging and management recommendations (Report of a multi-disciplinary expert committee)

Malhotra

Gupta

Mehrotra

et al. 2021

Journal of Oral Biology and Craniofacial Research

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Even before the onslaught of COVID-19 pandemic could settle, the unprecedented rise in cases with COVID-19 associated mucormycosis has pushed the medical health to the fringe. Hyperglycaemia and corticosteroids appear to be the most consistent associations leading to the commonest manifestation of mucormycosis, Rhino-Orbito-Cerebral Mucormycosis. To address challenges right from categorisation and staging of the disease to the management of relentless progression, a multi-disciplinary expert committee was formed to handle the task in an evidence-based format to enforce best practices. The report of the committee on one hand attempts to succinctly present the currently available evidence while at the other also attempts to bridge the evidence-deficient gaps with the specialty-specific virtuosity of experts.

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Hyperbaric oxygen therapy: Can it be a novel supportive therapy in COVID-19?

Cited by 19 publications

References 21 publications

An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19)

An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19)

A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities

COVID-19 associated mucormycosis: Staging and management recommendations (Report of a multi-disciplinary expert committee)

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