Hyperbaric oxygen therapy for acute coronary syndrome

Bennett, Michael H; Lehm, Jan P; Jepson, Nigel

doi:10.1002/14651858.cd004818.pub3

Cited by 30 publications

(17 citation statements)

References 28 publications

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“…Again, an appropriately powered trial of high methodological rigour is required to define those patients (if any) who can be expected to derive most benefit from HBO. At present, its routine application cannot be justified .…”

Section: Oxygen Treatment In Diseased Statesmentioning

confidence: 99%

The medical use of oxygen: a time for critical reappraisal

2013

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Section: Oxygen Treatment In Diseased Statesmentioning

confidence: 99%

The medical use of oxygen: a time for critical reappraisal

2013

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“…Hyperbaric oxygen therapy is a safe procedure defined by the Undersea and Hyperbaric Medical Society as a treatment where 100% O 2 is breathed inside a pressurized chamber in which the pressure is higher than 1 absolute atmosphere (101 kPa) 6 . Previous studies have analysed the myocardial protective effects of HBO on ischaemia–reperfusion injury in both animal models 7–10 and humans 11–13 . To the best of our knowledge, only one study 8 evaluated the effect of HBO on MI 24 h after occlusion and therapy.…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygenation Applied Immediately After Coronary Occlusion Reduces Myocardial Necrosis and Acute Mortality in Rats

Santos¹,

Serra²,

Antônio³

et al. 2009

Clin Exp Pharma Physio

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1. Because in ischaemia there is a critical lack of O2, it has been reasoned that increasing O2 delivery to the ischaemic myocardium could serve as adjunctive therapy for acute myocardial infarction (MI). Accordingly, in the present study, the effect of early hyperbaric oxygenation (HBO) on mortality and MI size after coronary occlusion was examined in rats. 2. After coronary occlusion, male Wistar rats were randomly assigned to receive either HBO for 1 h in a hyperbaric chamber (100% O(2) at 253 kPa; n = 106) or ambient O2 as the control (n = 111). The extent of myocardial necrosis was assessed (triphenyltetrazolium) immediately after treatment in the HBO (n = 50) and control (n = 47) groups. The remaining rats were evaluated 24 h after occlusion to enable calculation of MI size and mortality. 3. Immediately after therapy, the size of the MI was significantly greater in the control group compared with that in the HBO group (40 +/- 3 vs 27 +/- 2% of the left ventricle (LV), respectively; P < 0.001). The 24 h mortality of control rats was higher than that of HBO rats (34 vs 16%, respectively; P = 0.02). Control rats that survived 24 h had a larger MI than did HBO rats that survived 24 h (40 +/- 4 vs 29 +/- 3% of the LV, respectively; P = 0.005). Furthermore, large necrotic areas (> 40% of the LV) were more frequent in control than HBO rats (55 vs 27% of infarcted hearts, respectively; P = 0.01). There was less pulmonary congestion observed in HBO rats compared with control rats. 4. In conclusion, early therapy with HBO during the onset of an acute ischaemic event decreases the necrotic area and reduces acute mortality. These data support further investigation of HBO as an adjuvant therapy for acute MI.

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“…Furthermore, hs-CRP, a maker of the inflammatory response involved in many types of acute and chronic physiological inflammation, is thought to be closely related to SCF onset [10,11]. According to Bennett's report [15], HBO treatment can reduce myocardial ischemia and mortality rate of patients suffering from acute coronary syndrome. Another study from Khan et al [16] showed that HBO treatment can increase myocardial oxygen supply, and enhance the expression of vascular endothelial growth factors and the recovery of cardiomyocytes, and can also significantly improve the efficacy of stem-cell transplantationtreated myocardial infarct rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of hyperbaric oxygen on vascular endothelial function in patients with slow coronary flow

Li¹,

Zhang

Liang

et al. 2018

Cardiol J.

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Background: To improve therapy for slow coronary flow (SCF), the effects of hyperbaric oxygen (HBO) therapy on vascular endothelial function in divided into two groups according to the following treatment: HBO group (n = 48) and the control group (n = 50). Patients in the control group were administrated with conventional treatment, while those in the HBO group were administrated HBO therapy for 4 weeks in addition to conventional treatment. To evaluate the effects of HBO on vascular endothelial functions, plasma levels of nitric oxide (NO), calcitonin gene-related peptide (CGRP), endothelin-1 (ET-1), high sensitivity C-reactive protein (hsCRP) as well as endothelial-dependent flowmediated vasodilation (FMD) of the brachial artery were measured in both groups before and after their respective treatments.Results: There were no significant differences in plasma levels of NO, CGRP, hsCRP (Cardiol J 2018; 25, 1: 106-112)

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Hyperbaric oxygen therapy for acute coronary syndrome

Cited by 30 publications

References 28 publications

The medical use of oxygen: a time for critical reappraisal

The medical use of oxygen: a time for critical reappraisal

Hyperbaric Oxygenation Applied Immediately After Coronary Occlusion Reduces Myocardial Necrosis and Acute Mortality in Rats

Effects of hyperbaric oxygen on vascular endothelial function in patients with slow coronary flow

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